WFRF:(Larsson Gabriella)
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LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04093naa a2200589 4500 | |
| 001 | oai:DiVA.org:kth-173428 | |
| 003 | SwePub | |
| 008 | 150911s2015 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:131827013 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-1734282 URI |
| 024 | 7 | a https://doi.org/10.1016/j.bbrc.2015.07.0172 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1318270132 URI |
| 040 | a (SwePub)kthd (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Barrefelt, Asau Karolinska Institutet4 aut |
| 245 | 1 0 | a Fluorescence labeled microbubbles for multimodal imaging |
| 264 | 1 | b Elsevier BV,c 2015 |
| 338 | a print2 rdacarrier | |
| 500 | a QC 20150914 | |
| 520 | a Air-filled polyvinyl alcohol microbubbles (PVA-MBs) were recently introduced as a contrast agent for ultrasound imaging. In the present study, we explore the possibility of extending their application in multimodal imaging by labeling them with a near infrared (NIR) fluorophore, VivoTag-680. PVA-MBs were injected intravenously into FVB/N female mice and their dynamic biodistribution over 24 h was determined by 3D-fluorescence imaging co-registered with 3D-mu CT imaging, to verify the anatomic location. To further confirm the biodistribution results from in vivo imaging, organs were removed and examined histologically using bright field and fluorescence microscopy. Fluorescence imaging detected PVA-MB accumulation in the lungs within the first 30 min post-injection. Redistribution to a low extent was observed in liver and kidneys at 4 h, and to a high extent mainly in the liver and spleen at 24 h. Histology confirmed PVA-MB localization in lung capillaries and macrophages. In the liver, they were associated with Kupffer cells; in the spleen, they were located mostly within the marginal-zone. Occasional MBs were observed in the kidney glomeruli and interstitium. The potential application of PVA-MBs as a contrast agent was also studied using ultrasound (US) imaging in subcutaneous and orthotopic pancreatic cancer mouse models, to visualize blood flow within the tumor mass. In conclusion, this study showed that PVA-MBs are useful as a contrast agent for multimodal imaging. (C) 2015 Elsevier Inc. All rights reserved. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Biologix Biofysik0 (SwePub)106032 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biophysics0 (SwePub)106032 hsv//eng |
| 653 | a In vivo imaging systems | |
| 653 | a Micro-computed tomography | |
| 653 | a Micro-ultrasound | |
| 653 | a Microbubbles | |
| 653 | a VivoTag 680 | |
| 653 | a Near infrared (NIR) | |
| 653 | a Fluorescence | |
| 700 | 1 | a Zhao, Yingu Karolinska Institutet4 aut |
| 700 | 1 | a Larsson, Malin K.u KTH,Medicinsk bildteknik4 aut0 (Swepub:kth)u1h41lrg |
| 700 | 1 | a Egri, Gabriella4 aut |
| 700 | 1 | a Kuiper, Raoul V.u Karolinska Institutet4 aut |
| 700 | 1 | a Hamm, Jorg4 aut |
| 700 | 1 | a Saghafian, Maryam4 aut |
| 700 | 1 | a Caidahl, Kennethu Karolinska Institutet4 aut |
| 700 | 1 | a Brismar, Torkel B.u Karolinska Institutet4 aut |
| 700 | 1 | a Aspelin, Peteru Karolinska Institutet4 aut |
| 700 | 1 | a Heuchel, Raineru Karolinska Institutet4 aut |
| 700 | 1 | a Muhammed, Mamounu Karolinska Institutet4 aut |
| 700 | 1 | a Dahne, Lars4 aut |
| 700 | 1 | a Hassan, Moustapha4 aut |
| 710 | 2 | a Karolinska Institutetb Medicinsk bildteknik4 org |
| 773 | 0 | t Biochemical and Biophysical Research Communications - BBRCd : Elsevier BVg 464:3, s. 737-742q 464:3<737-742x 0006-291Xx 1090-2104 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-173428 |
| 856 | 4 8 | u https://doi.org/10.1016/j.bbrc.2015.07.017 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:131827013 |
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