Sökning: onr:"swepub:oai:DiVA.org:uu-489752" > Cardiac biomarkers ...
Fältnamn | Indikatorer | Metadata |
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000 | 04053naa a2200613 4500 | |
001 | oai:DiVA.org:uu-489752 | |
003 | SwePub | |
008 | 221204s2021 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4897522 URI |
024 | 7 | a https://doi.org/10.2459/jcm.00000000000012812 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Vergaro, Giuseppe4 aut |
245 | 1 0 | a Cardiac biomarkers retain prognostic significance in patients with heart failure and chronic obstructive pulmonary disease |
264 | c 2021-11-26 | |
264 | 1 | b Wolters Kluwer,c 2021 |
338 | a print2 rdacarrier | |
520 | a Aim: Chronic obstructive pulmonary disease (COPD) is a frequent comorbidity in patients with heart failure (HF). We assessed the influence of COPD on circulating levels and prognostic value of three HF biomarkers: N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), and soluble suppression of tumorigenesis-2 (sST2).Methods: Individual data from patients with chronic HF, known COPD status, NT-proBNP and hs-TnT values (n = 8088) were analysed. A subgroup (n = 3414) had also sST2 values.Results: Patients had a median age of 66 years (interquartile interval 57–74), 77% were men and 82% had HF with reduced ejection fraction. NT-proBNP, hs-TnT and sST2 were 1207 ng/l (487–2725), 17 ng/l (9–31) and 30 ng/ml (22–44), respectively. Patients with COPD (n = 1249, 15%) had higher NT-proBNP (P = 0.042) and hs-TnT (P < 0.001), but not sST2 (P = 0.165). Over a median 2.0-year follow-up (1.5–2.5), 1717 patients (21%) died, and 1298 (16%) died from cardiovascular causes; 2255 patients (28%) were hospitalized for HF over 1.8 years (0.9–2.1). NT-proBNP, hs-TnT and sST2 predicted the three end points regardless of COPD status. The best cut-offs from receiver-operating characteristics analysis were higher in patients with COPD than in those without. Patients with all three biomarkers higher than or equal to end-point- and COPD-status-specific cut-offs were also those with the worst prognosis.Conclusions: Among patients with HF, those with COPD have higher NT-proBNP and hs-TnT, but not sST2. All these biomarkers yield prognostic significance regardless of the COPD status. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
700 | 1 | a Aimo, Alberto4 aut |
700 | 1 | a Januzzi, James L.4 aut |
700 | 1 | a Richards, A. Mark4 aut |
700 | 1 | a Lam, Carolyn S.P.4 aut |
700 | 1 | a Latini, Roberto4 aut |
700 | 1 | a Staszewsky, Lidia4 aut |
700 | 1 | a Anand, Inder S.4 aut |
700 | 1 | a Ueland, Thor4 aut |
700 | 1 | a Brunner-La Rocca, Hans-Peter4 aut |
700 | 1 | a Bayes-Genis, Antoni4 aut |
700 | 1 | a Lupón, Josep4 aut |
700 | 1 | a de Boer, Rudolf A.4 aut |
700 | 1 | a Yoshihisa, Akiomi4 aut |
700 | 1 | a Takeishi, Yasuchika4 aut |
700 | 1 | a Gustafsson, Ida4 aut |
700 | 1 | a Eggers, Kai M.,d 1962-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)kaieg561 |
700 | 1 | a Huber, Kurt4 aut |
700 | 1 | a Gamble, Greg D.4 aut |
700 | 1 | a Leong, Kui Toh Gerard4 aut |
700 | 1 | a Yeo, Poh Shuan Daniel4 aut |
700 | 1 | a Ong, Hean Yee4 aut |
700 | 1 | a Jaufeerally, Fazlur4 aut |
700 | 1 | a Ng, Tze P.4 aut |
700 | 1 | a Troughton, Richard4 aut |
700 | 1 | a Doughty, Robert N.4 aut |
700 | 1 | a Emdin, Michele4 aut |
700 | 1 | a Passino, Claudio4 aut |
710 | 2 | a Uppsala universitetb Uppsala kliniska forskningscentrum (UCR)4 org |
773 | 0 | t Journal of Cardiovascular Medicined : Wolters Kluwerg 23:1, s. 28-36q 23:1<28-36x 1558-2027x 1558-2035 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-489752 |
856 | 4 8 | u https://doi.org/10.2459/jcm.0000000000001281 |
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