Sökning: WFRF:(Le Marchand Loic) > (2005-2009) > Vitamin D Receptor ...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04718naa a2200733 4500 | |
001 | oai:lup.lub.lu.se:850ab45b-5a68-45b8-8657-aae3449094d7 | |
003 | SwePub | |
008 | 160401s2009 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/13128682 URI |
024 | 7 | a https://doi.org/10.1158/1055-9965.EPI-08-05392 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a McKay, James D.4 aut |
245 | 1 0 | a Vitamin D Receptor Polymorphisms and Breast Cancer Risk: Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium |
264 | 1 | c 2009 |
520 | a Background: Vitamin D is hypothesized to lower the risk of breast cancer by inhibiting cell proliferation via the nuclear vitamin D receptor (VDR). Two common single nucleotide polymorphisms (SNP) in the VDR gene (VDR), rs154441.0 (BsmI), and rs2228570 (FokI), have been inconsistently associated with breast cancer risk. Increased risk has been reported for the FokIff genotype, which encodes a less transcriptionally active isoform of VDR, and reduced risk has been reported for the BsmI BB genotype, a SNP in strong linkage disequilibrium with a 3'-untranslated region, which may influence VDR mRNA stability. Methods: We pooled data from 6 prospective studies in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium to examine associations between these SNPs and breast cancer among >6,300 cases and 8,100 controls for each SNP using conditional logistic regression. Results: The odds ratio (OR) for the rs2228570 (FokI) ff versus FF genotype in the overall population was statistically significantly elevated [OR, 1-1.6; 95% confidence interval (95% CI), 1.04-1.28] but was weaker once data from the cohort with previously published positive findings were removed (OR, 1.1.0; 95% CI, 0.981.24). No association was noted between rs1544410 (Bsm I) BB and breast cancer risk overall (OR, 0.98; 95% CI, 0.89-1.09), but the BB genotype was associated with a significantly lower risk of advanced breast cancer (OR, 0.74; 95% CI, 0.60-0.92). Conclusions: Although the evidence for independent contributions of these variants to breast cancer susceptibility remains equivocal, future large studies should integrate genetic variation in VDR with biomarkers of vitamin D status. (Cancer Epidemiol Biomarkers Prev 2009;18(1):297-305) | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a McCullough, Marjorie L.4 aut |
700 | 1 | a Ziegler, Regina G.4 aut |
700 | 1 | a Kraft, Peter4 aut |
700 | 1 | a Saltzman, Barbara S.4 aut |
700 | 1 | a Riboli, Elio4 aut |
700 | 1 | a Barricarte, Aurelio4 aut |
700 | 1 | a Berg, Christine D.4 aut |
700 | 1 | a Berglund, Göranu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-gbe |
700 | 1 | a Bingham, Sheila4 aut |
700 | 1 | a Brustad, Magritt4 aut |
700 | 1 | a Bueno-de-Mesquita, H. Bas4 aut |
700 | 1 | a Burdette, Laurie4 aut |
700 | 1 | a Buring, Julie4 aut |
700 | 1 | a Calle, Eugenia E.4 aut |
700 | 1 | a Chanock, Stephen J.4 aut |
700 | 1 | a Clavel-Chapelon, Francoise4 aut |
700 | 1 | a Cox, David G.4 aut |
700 | 1 | a Dossus, Laure4 aut |
700 | 1 | a Feigelson, Heather Spencer4 aut |
700 | 1 | a Haiman, Christopher A.4 aut |
700 | 1 | a Hankinson, Susan E.4 aut |
700 | 1 | a Hoover, Robert N.4 aut |
700 | 1 | a Hunter, David J.4 aut |
700 | 1 | a Husing, Anika4 aut |
700 | 1 | a Kaaks, Rudolph4 aut |
700 | 1 | a Kolonel, Laurence N.4 aut |
700 | 1 | a Le Marchand, Loic4 aut |
700 | 1 | a Linseisen, Jakob4 aut |
700 | 1 | a McCarty, Catherine A.4 aut |
700 | 1 | a Overvad, Kim4 aut |
700 | 1 | a Panico, Salvatore4 aut |
700 | 1 | a Purdue, Mark P.4 aut |
700 | 1 | a Stram, Daniel O.4 aut |
700 | 1 | a Stevens, Victoria L.4 aut |
700 | 1 | a Trichopoulos, Dimitrios4 aut |
700 | 1 | a Willett, Walter C.4 aut |
700 | 1 | a Yuenger, Jeffrey4 aut |
700 | 1 | a Thun, Michael J.4 aut |
710 | 2 | a Internmedicin - epidemiologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Cancer Epidemiology Biomarkers & Preventiong 18:1, s. 297-305q 18:1<297-305x 1538-7755 |
856 | 4 | u http://dx.doi.org/10.1158/1055-9965.EPI-08-0539y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/1312868 |
856 | 4 8 | u https://doi.org/10.1158/1055-9965.EPI-08-0539 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy