Sökning: WFRF:(Liu Pan) > (2005-2009) > Non-homologous end ...
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000 | 02664naa a2200325 4500 | |
001 | oai:prod.swepub.kib.ki.se:118253495 | |
003 | SwePub | |
008 | 240701s2009 | |||||||||||000 ||eng| | |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1182534952 URI |
024 | 7 | a https://doi.org/10.1098/rstb.2008.01962 DOI |
040 | a (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Kotnis, A4 aut |
245 | 1 0 | a Non-homologous end joining in class switch recombination: the beginning of the end |
264 | c 2008-11-13 | |
264 | 1 | b The Royal Society,c 2009 |
520 | a Immunoglobulin class switch recombination (CSR) is initiated by a B-cell-specific factor, activation-induced deaminase, probably through deamination of deoxycytidine residues within the switch (S) regions. The initial lesions in the S regions are subsequently processed, resulting in the production of DNA double-strand breaks (DSBs). These breaks will then be recognized, edited and repaired, finally leading to the recombination of the two S regions. Two major repair pathways have been implicated in CSR, the predominant non-homologous end joining (NHEJ) and the alternative end-joining (A-EJ) pathways. The former requires not only components of the ‘classical’ NHEJ machinery, i.e. Ku70/Ku80, DNA-dependent protein kinase catalytic subunit, DNA ligase IV and XRCC4, but also a number of DNA-damage sensors or adaptors, such as ataxia–telangiectasia mutated, γH2AX, 53BP1, MDC1, the Mre11–Rad50–NBS1 complex and the ataxia telangiectasia and Rad3-related protein (ATR). The latter pathway is not well characterized yet and probably requires microhomologies. In this review, we will focus on the current knowledge of the predominant NHEJ pathway in CSR and will also give a perspective on the A-EJ pathway. | |
700 | 1 | a Du, LKu Karolinska Institutet4 aut |
700 | 1 | a Liu, CH4 aut |
700 | 1 | a Popov, SW4 aut |
700 | 1 | a Pan-Hammarstrom, Qu Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutet4 org |
773 | 0 | t Philosophical transactions of the Royal Society of London. Series B, Biological sciencesd : The Royal Societyg 364:1517, s. 653-665q 364:1517<653-665x 1471-2970 |
773 | 0 | t Philosophical Transactions of the Royal Society B: Biological Sciencesd : The Royal Societyg 364:1517, s. 653-665q 364:1517<653-665x 0962-8436 |
856 | 4 | u http://rstb.royalsocietypublishing.org/content/364/1517/653.full.pdf |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:118253495 |
856 | 4 8 | u https://doi.org/10.1098/rstb.2008.0196 |
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