Common genetic determinants of glucose homeostasis in healthy children: the European youth heart study

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Loos Ruth J F) > (2006-2009) > Common genetic dete...

Common genetic determinants of glucose homeostasis in healthy children : the European youth heart study

Kelliny, Clara (author)

Ekelund, Ulf (author): Örebro universitet,Hälsoakademin

Andersen, Lars Bo (author)

Brage, Sören (author)

Loos, Ruth J. F. (author)

Wareham, Nicholas J. (author)

Langenberg, Claudia (author)

show less...

(creator_code:org_t)

2009-09-09
2009
English.
In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 58:12, s. 2939-2945

Related links:: http://diabetes.diab...; show more...; https://urn.kb.se/re...; https://doi.org/10.2...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

OBJECTIVE-The goal of this study was to investigate whether the effects of common genetic variants associated with fasting glucose in adults are detectable in healthy children. RESEARCH DESIGN AND METHODS-Single nucleotide polymorphisms in MTNR1B (rs10830963), G6PC2 (rs560887), and GCK (rs4607517) were genotyped in 2,025 healthy European children aged 9-11 and 14-16 years. Associations with fasting glucose, insulin, homeostasis model assessment (HOMA)-insulin resistance (IR) and HOMA-B were investigated along with those observed for type 2 diabetes variants available in this study (CDKN2A/B, IGF2BP2, CDKAL1, SLC30A8, HHEX-IDE, and Chr 11p12). RESULTS-Strongest associations were observed for G6PC2 and MTNR1B, with mean fasting glucose levels (95% Cl) being 0.084 (0.06-0.11) mmol/l, P = 7.9 x 10(-11) and 0.069 (0.04-0.09) mmol/l, p = 1.9 x 10(-7) higher per risk allele copy, respectively. A similar but weaker trend was observed for GCK (0.028 [-0.006 to 0.06] mmol/l, P = 0.11). All three variants were associated with lower P-cell function (HOMA-B P = 9.38 x 10(-5), 0.004, and 0.04, respectively). SLC30A8 (rs13266634) was the only type 2 diabetes variant associated with higher fasting glucose (0.033 mmol/l [0.01-0.06], P = 0.01). Calculating a genetic predisposition score adding the number of risk alleles of G6PC2, MTNR1B, GCK, and SLC30A8 showed that glucose levels were successively higher in children carrying a greater number of risk alleles (P = 7.1 x 10(-17)), with mean levels of 5.34 versus 4.91 mmol/l comparing children with seven alleles (0.6% of all children) to those with none (0.5%). No associations were found for fasting insulin or HOMA-IR with any of the variants. CONCLUSIONS-The effects of common polymorphisms influencing fasting glucose are apparent in healthy children, whereas the presence of multiple risk alleles amounts to a difference of >1 SD of fasting glucose. Diabetes 58:2939-2945, 2009

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)

Keyword

Sports Science
Idrottsvetenskap

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

Diabetes (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Kelliny, Clara; Ekelund, Ulf; Andersen, Lars B ...; Brage, Sören; Loos, Ruth J. F.; Wareham, Nichola ...; show more...; Langenberg, Clau ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Sport and Fitnes ...

Articles in the publication: Diabetes

By the university: Örebro University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se