SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Maiga Boubacar)
 

Sökning: WFRF:(Maiga Boubacar) > Persistence of full...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003604naa a2200493 4500
001oai:DiVA.org:su-45675
003SwePub
008101110s2010 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-456752 URI
040 a (SwePub)su
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a McCall, Matthew B B4 aut
2451 0a Persistence of full-length caspase-12 and its relation to malaria in West and Central African populations
264 1c 2010
338 a print2 rdacarrier
520 a Background. The full-length (L-) variant of caspase-12 is believed to predispose to sepsis. It has been replaced in the genome of most human populations by the (S-) variant, which leads to premature termination of translation. Strikingly, the L-allele is still widely prevalent in African populations, presumably due to a counterbalancing selective force specific to this continent, for which malaria is a prime candidate.Methods. We investigated associations between caspase-12 genotype and malarial parameters in three West-African populations, in studies encompassing immunological, clinical and obstetric data. Results. The caspase-12 L-allele was found at frequencies of 11-34%. Plasmodium falciparum-stimulated mononuclear cells from S/L heterozygote donors produced stronger interferon-γ and interleukin-10 responses than S/S homozygotes (p = 0.011 and p = 0.023 in uninfected and infected donors respectively). Nevertheless, we found no association between caspase-12 genotype and either the presentation of severe malaria or individual clinical parameters in sick children. Amongst pregnant women, the caspase-12 genotype did not influence peripheral or placental malaria infection, or basic obstetric parameters. Interestingly, perinatal mortality was more frequent in children of both S/S and L/L than S/L mothers, independent of placental P. falciparum-infection.Conclusion. We find little clinical or epidemiological evidence that malaria has contributed to the persistence of functional caspase-12 in Africa, suggesting either that alternative selective forces are at work or that genetic drift underlies its current global distribution.
650 7a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
653 a NATURAL SCIENCES
653 a NATURVETENSKAP
7001 a Ferwerda, Bart4 aut
7001 a Hopman, Joost4 aut
7001 a Ploemen, Ivo4 aut
7001 a Maiga, Boubacar4 aut
7001 a Daou, Modibo4 aut
7001 a Dolo, Amagana4 aut
7001 a Hermsen, Cornelus C4 aut
7001 a Doumbo, Ogobara K4 aut
7001 a Bedu-Addo, George4 aut
7001 a van der Meer, Jos W4 aut
7001 a Troye-Blomberg, Maritau Stockholms universitet,Avdelningen för immunologi4 aut0 (Swepub:su)marita
7001 a van der Ven, André J A M4 aut
7001 a Schumann, Ralf R4 aut
7001 a Sauerwein, Robert W4 aut
7001 a Mockenhaupt, Frank P4 aut
7001 a Netea, Mihai G4 aut
7102 a Stockholms universitetb Avdelningen för immunologi4 org
7730 t European Cytokine Networkg 21:2, s. 77-83q 21:2<77-83x 1148-5493x 1952-4005
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-45675

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy