WFRF:(Manell Hannes)
Search: WFRF:(Manell Hannes) > (2017) > Pancreatic Fat Is A...
- 7 of 7
- Previous record
- Next record
- To hitlist
Pancreatic Fat Is Associated With Metabolic Syndrome and Visceral Fat but Not Beta-Cell Function or Body Mass Index in Pediatric Obesity
-
- Staaf, Johan (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Institutionen för kvinnors och barns hälsa
- Labmayr, Viktor (author)
- Paulmichl, Katharina (author)
- show more...
- Roomp, Kirsten (author)
- Anderwald, Christian-Heinz (author)
- Meissnitzer, Matthias (author)
- Schneider, Reinhard (author)
- Widhalm, Kurt (author)
- Weghuber, Daniel (author)
- show less...
- (creator_code:org_t)
- 2017
- 2017
- English.
- In: Pancreas. - 0885-3177 .- 1536-4828. ; 46:3, s. 358-365
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- OBJECTIVE: Adolescents with obesity have increased risk of type 2 diabetes and metabolic syndrome (MetS). Pancreatic fat has been related to these conditions; however, little is known about associations in pediatric obesity. The present study was designed to explore these associations further.METHODS: We examined 116 subjects, 90 with obesity. Anthropometry, MetS, blood samples, and oral glucose tolerance tests were assessed using standard techniques. Pancreatic fat fraction (PFF) and other fat depots were quantified using magnetic resonance imaging.RESULTS: The PFF was elevated in subjects with obesity. No association between PFF and body mass index-standard deviation score (BMI-SDS) was found in the obesity subcohort. Pancreatic fat fraction correlated to Insulin Secretion Sensitivity Index-2 and Homeostatic Model Assessment of Insulin Resistance in simple regression; however, when using adjusted regression and correcting for BMI-SDS and other fat compartments, PFF correlated only to visceral adipose tissue and fasting glucose. Highest levels of PFF were found in subjects with obesity and MetS.CONCLUSIONS: In adolescents with obesity, PFF is elevated and associatedto MetS, fasting glucose, and visceral adipose tissue but not to beta-cellfunction, glucose tolerance, or BMI-SDS. This study demonstrates thatconclusions regarding PFF and its associations depend on the body massfeatures of the cohort.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- pancreatic fat
- pediatric obesity
- beta-cell function
- metabolic syndrome
- body mass index-standard deviation score
Publication and Content Type
- ref (subject category)
- art (subject category)
- 7 of 7
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Staaf, Johan
- Labmayr, Viktor
- Paulmichl, Katha ...
- Manell, Hannes
- Cen, Jing
- Ciba, Iris
- show more...
- Dahlbom, Marie
- Roomp, Kirsten
- Anderwald, Chris ...
- Meissnitzer, Mat ...
- Schneider, Reinh ...
- Forslund, Anders
- Widhalm, Kurt
- Bergquist, Jonas
- Ahlström, Håkan
- Bergsten, Peter
- Weghuber, Daniel
- Kullberg, Joel
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Endocrinology an ...
- Articles in the publication
- Pancreas
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
