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Sökning: WFRF:(Matthiesen Leif) > (2005-2009) > Systemic reduction ...

  • Mjösberg, JennyLinköpings universitet,Klinisk immunologi,Hälsouniversitetet (författare)

Systemic reduction of functionally suppressive CD4dimCD25highFoxp3+ Tregs in human second trimester pregnancy is induced by progesterone and 17θ-estradiol

  • Artikel/kapitelEngelska2009

Förlag, utgivningsår, omfång ...

  • The American Association of Immunologists,2009
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-53104
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-53104URI
  • https://doi.org/10.4049/jimmunol.0803654DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • CD4+CD25high regulatory T cells (Tregs) are implicated in the maintenance of murine pregnancy. However, reports regarding circulating Treg frequencies in human pregnancy are inconsistent, and the functionality and phenotype of these cells in pregnancy have not been clarified. The aim of this study was to determine the frequency, phenotype, and function of circulating Tregs in the second trimester of human pregnancy and the influence of progesterone and 17β-estradiol on Treg phenotype and frequency. Based on expressions of Foxp3, CD127, and HLA-DR as determined by multicolor flow cytometry, we defined a proper CD4dimCD25high Treg population and showed, in contrast to most previous reports, that this population was reduced in second trimester of pregnancy. Unexpectedly, Foxp3 expression was decreased in the Treg, as well as in the CD4+ population. These changes could be replicated in an in vitro system resembling the pregnancy hormonal milieu, where 17β-estradiol, and in particular progesterone, induced, in line with the pregnancy situation, a reduction of CD4dimCD25highFoxp3+ cells in PBMC from nonpregnant women. By coculturing FACS-sorted Tregs and autologous CD4+CD25– responder cells, we showed that Tregs from pregnant women still displayed the same suppressive capacity as nonpregnant women in terms of suppressing IL-2, TNF-, and IFN- secretion from responder cells while efficiently producing IL-4 and IL-10. Our findings support the view of hormones, particularly progesterone, as critical regulators of Tregs in pregnancy. Furthermore, we suggest that in the light of the results of this study, early data on circulating Treg frequencies in pregnancy need reevaluation.The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Ämnesord och genrebeteckningar

  • MEDICINE
  • MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Svensson, JuditLinköpings universitet,Klinisk immunologi,Hälsouniversitetet(Swepub:liu)judsv82 (författare)
  • Johansson, EmmaLinköpings universitet,Klinisk immunologi,Hälsouniversitetet(Swepub:liu)emmjo00 (författare)
  • Hellström, LottaLinköpings universitet,Klinisk immunologi,Geriatrik,Hälsouniversitetet(Swepub:liu)lothe38 (författare)
  • Casas, RosauraLinköpings universitet,Pediatrik,Hälsouniversitetet(Swepub:liu)rosca56 (författare)
  • Jenmalm, MariaLinköpings universitet,Pediatrik,Hälsouniversitetet(Swepub:liu)marje18 (författare)
  • Boij, RolandRyhov Hospital, Jönköping, Sweden (författare)
  • Matthiesen, LeifHelsingborg Hospital, Helsingborg, Sweden (författare)
  • Jönsson, Jan-IngvarLinköpings universitet,Cellbiologi,Hälsouniversitetet(Swepub:liu)janjo86 (författare)
  • Berg, GöranÖstergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping(Swepub:liu)gorbe09 (författare)
  • Ernerudh, JanÖstergötlands Läns Landsting,Linköpings universitet,Klinisk immunologi,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin(Swepub:liu)janer15 (författare)
  • Linköpings universitetKlinisk immunologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Immunology: The American Association of Immunologists183:1, s. 759-7690022-17671550-6606

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