WFRF:(Matthiesen Leif)
Sökning: WFRF:(Matthiesen Leif) > (2005-2009) > Systemic reduction ...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04604naa a2200421 4500 | |
| 001 | oai:DiVA.org:liu-53104 | |
| 003 | SwePub | |
| 008 | 100115s2009 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-531042 URI |
| 024 | 7 | a https://doi.org/10.4049/jimmunol.08036542 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Mjösberg, Jennyu Linköpings universitet,Klinisk immunologi,Hälsouniversitetet4 aut0 (Swepub:liu)jenmj65 |
| 245 | 1 0 | a Systemic reduction of functionally suppressive CD4dimCD25highFoxp3+ Tregs in human second trimester pregnancy is induced by progesterone and 17θ-estradiol |
| 264 | 1 | b The American Association of Immunologists,c 2009 |
| 338 | a electronic2 rdacarrier | |
| 520 | a CD4+CD25high regulatory T cells (Tregs) are implicated in the maintenance of murine pregnancy. However, reports regarding circulating Treg frequencies in human pregnancy are inconsistent, and the functionality and phenotype of these cells in pregnancy have not been clarified. The aim of this study was to determine the frequency, phenotype, and function of circulating Tregs in the second trimester of human pregnancy and the influence of progesterone and 17β-estradiol on Treg phenotype and frequency. Based on expressions of Foxp3, CD127, and HLA-DR as determined by multicolor flow cytometry, we defined a proper CD4dimCD25high Treg population and showed, in contrast to most previous reports, that this population was reduced in second trimester of pregnancy. Unexpectedly, Foxp3 expression was decreased in the Treg, as well as in the CD4+ population. These changes could be replicated in an in vitro system resembling the pregnancy hormonal milieu, where 17β-estradiol, and in particular progesterone, induced, in line with the pregnancy situation, a reduction of CD4dimCD25highFoxp3+ cells in PBMC from nonpregnant women. By coculturing FACS-sorted Tregs and autologous CD4+CD25– responder cells, we showed that Tregs from pregnant women still displayed the same suppressive capacity as nonpregnant women in terms of suppressing IL-2, TNF-, and IFN- secretion from responder cells while efficiently producing IL-4 and IL-10. Our findings support the view of hormones, particularly progesterone, as critical regulators of Tregs in pregnancy. Furthermore, we suggest that in the light of the results of this study, early data on circulating Treg frequencies in pregnancy need reevaluation.The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Svensson, Juditu Linköpings universitet,Klinisk immunologi,Hälsouniversitetet4 aut0 (Swepub:liu)judsv82 |
| 700 | 1 | a Johansson, Emmau Linköpings universitet,Klinisk immunologi,Hälsouniversitetet4 aut0 (Swepub:liu)emmjo00 |
| 700 | 1 | a Hellström, Lottau Linköpings universitet,Klinisk immunologi,Geriatrik,Hälsouniversitetet4 aut0 (Swepub:liu)lothe38 |
| 700 | 1 | a Casas, Rosaurau Linköpings universitet,Pediatrik,Hälsouniversitetet4 aut0 (Swepub:liu)rosca56 |
| 700 | 1 | a Jenmalm, Mariau Linköpings universitet,Pediatrik,Hälsouniversitetet4 aut0 (Swepub:liu)marje18 |
| 700 | 1 | a Boij, Rolandu Ryhov Hospital, Jönköping, Sweden4 aut |
| 700 | 1 | a Matthiesen, Leifu Helsingborg Hospital, Helsingborg, Sweden4 aut |
| 700 | 1 | a Jönsson, Jan-Ingvaru Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)janjo86 |
| 700 | 1 | a Berg, Göranu Östergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping4 aut0 (Swepub:liu)gorbe09 |
| 700 | 1 | a Ernerudh, Janu Östergötlands Läns Landsting,Linköpings universitet,Klinisk immunologi,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin4 aut0 (Swepub:liu)janer15 |
| 710 | 2 | a Linköpings universitetb Klinisk immunologi4 org |
| 773 | 0 | t Journal of Immunologyd : The American Association of Immunologistsg 183:1, s. 759-769q 183:1<759-769x 0022-1767x 1550-6606 |
| 856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:286812/FULLTEXT03.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u http://www.jimmunol.org/content/jimmunol/183/1/759.full.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-53104 |
| 856 | 4 8 | u https://doi.org/10.4049/jimmunol.0803654 |
Hitta mer i SwePub
- Av författaren/redakt...
- Mjösberg, Jenny
- Svensson, Judit
- Johansson, Emma
- Hellström, Lotta
- Casas, Rosaura
- Jenmalm, Maria
- visa fler...
- Boij, Roland
- Matthiesen, Leif
- Jönsson, Jan-Ing ...
- Berg, Göran
- Ernerudh, Jan
- visa färre...
- Artiklar i publikationen
- Journal of Immun ...
- Av lärosätet
- Linköpings universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
