WFRF:(Memon Ashfaque)
Sökning: WFRF:(Memon Ashfaque) > (2020-2024) > Association of mito...
Association of mitochondrial DNA copy number with prevalent and incident type 2 diabetes in women : A population-based follow-up study
-
- Memon, Ashfaque A (författare)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Wallenberglaboratoriet, Malmö,Medicinska fakulteten,Family Medicine and Clinical Epidemiology,Lund University Research Groups,The Wallenberg Laboratory, Malmö,Faculty of Medicine,Skåne University Hospital,Center for Primary Health Care Research
-
- Sundquist, Jan (författare)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Wallenberglaboratoriet, Malmö,Medicinska fakulteten,Family Medicine and Clinical Epidemiology,Lund University Research Groups,The Wallenberg Laboratory, Malmö,Faculty of Medicine,Center for Primary Health Care Research,Skåne University Hospital
-
- Hedelius, Anna (författare)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Wallenberglaboratoriet, Malmö,Medicinska fakulteten,Family Medicine and Clinical Epidemiology,Lund University Research Groups,The Wallenberg Laboratory, Malmö,Faculty of Medicine,Skåne University Hospital,Center for Primary Health Care Research
- visa fler...
- visa färre...
- (creator_code:org_t)
- 2021-02-25
- 2021
- Engelska.
- Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Mitochondrial dysfunction is an important factor of the aging process and may play a key role in various diseases. Mitochondrial DNA copy number (mtDNA-CN) is an indirect measure of mitochondrial dysfunction and is associated with type 2 diabetes mellitus (T2DM); however, whether mtDNA-CN can predict the risk of developing T2DM is not well-known. We quantified absolute mtDNA-CN in both prevalent and incident T2DM by well-optimized droplet digital PCR (ddPCR) method in a population-based follow-up study of middle aged (50-59 years) Swedish women (n = 2387). The median follow-up period was 17 years. Compared to those who were free of T2DM, mtDNA-CN was significantly lower in both prevalent T2DM and in women who developed T2DM during the follow-up period. Mitochondrial DNA-copy number was also associated with glucose intolerance, systolic blood pressure, smoking status and education. In multivariable Cox regression analysis, lower baseline mtDNA-CN was prospectively associated with a higher risk of T2DM, independent of age, BMI, education, smoking status and physical activity. Moreover, interaction term analysis showed that smoking increased the effect of low mtDNA-CN at baseline on the risk of incident T2DM. Mitochondrial DNA-copy number may be a risk factor of T2DM in women. The clinical usefulness of mtDNA-CN to predict the future risk of T2DM warrants further investigation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta mer i SwePub
- Av författaren/redakt...
- Memon, Ashfaque ...
- Sundquist, Jan
- Hedelius, Anna
- Palmér, Karolina
- Wang, Xiao
- Sundquist, Krist ...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Hälsovetenskap
- och Folkhälsovetensk ...
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Endokrinologi oc ...
- Artiklar i publikationen
- Scientific Repor ...
- Av lärosätet
- Lunds universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
