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Characterization of the CDR3 region of rearranged alpha heavy chain genes in human fetal liver
- Baskin, B (author)
- Islam, KB (author)
-
- Smith, CIE (author)
- Karolinska Institutet
- (creator_code:org_t)
- 2001-12-25
- 1998
- English.
- In: Clinical and experimental immunology. - : Oxford University Press (OUP). - 0009-9104 .- 1365-2249. ; 112:1, s. 44-47
- Journal article (peer-reviewed)
Abstract
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- The human fetal liver is an early site for B cell development. Pre B cells are first detectable in human fetal life at 8 weeks of gestation, when the rearrangement of the μ heavy chain genes starts. In this study we characterize the CDR3 region of rearranged α heavy chain transcripts from four human fetal livers ranging from 8 to 11 weeks of gestation. Each fetal liver showed a limited number of variations in CDR3 sequences compared with adult peripheral blood mononuclear cells (PBMC). Sequence analysis of 91 clones demonstrated that there was no preference for the usage of a certain JH gene segment, whereas a preference for usage of DH family genes, DXP and DLR, was seen in most cases during early fetal life. This is the first study where rearranged α heavy chain genes in fetal liver have been characterized. Our data suggest that the usage of JH genes is random, while there is a preference for DH family genes in human fetal liver.
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