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Prediction of infla...
Prediction of inflammatory responses induced by biomaterials in contact with human blood using protein fingerprint from plasma
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- Engberg, Anna E. (author)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Region Skåne,Linnaeus Ctr Biomat Chem, BMC
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- Nilsson, Per H. (author)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Oslo Univ Hosp, Rikshosp, Norway;Univ Oslo, Norway,Linnaeus Ctr Biomat Chem, BMC;HoRB
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- Huang, Shan (author)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Linnaeus Ctr Biomat Chem, BMC
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- Fromell, Karin (author)
- Uppsala universitet,Klinisk immunologi
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- Hamad, Osama A. (author)
- Uppsala universitet,Klinisk immunologi
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- Mollnes, Tom Eirik (author)
- Univ Oslo, Norway;Univ Tromsö, Norway
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- Rosengren-Holmberg, Jenny P. (author)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Swedish Natl Lab Forens Sci, Linköping,Linnaeus Ctr Biomat Chem, BMC
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- Sandholm, Kerstin (author)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Linnaeus Ctr Biomat Chem, BMC
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- Teramura, Yuji (author)
- Uppsala universitet,Klinisk immunologi
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- Nicholls, Ian A. (author)
- Uppsala universitet,Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Uppsala University,BBCL;Linnaeus Ctr Biomat Chem, BMC,Institutionen för kemi - BMC
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- Nilsson, Bo (author)
- Uppsala universitet,Klinisk immunologi
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- Nilsson Ekdahl, Kristina (author)
- Uppsala universitet,Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Uppsala University,Linnaeus Ctr Biomat Chem, BMC,Klinisk immunologi
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
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In: Biomaterials. - : Elsevier BV. - 0142-9612 .- 1878-5905. ; 36, s. 55-65
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Inappropriate complement activation is often responsible for incompatibility reactions that occur when biomaterials are used. Complement activation is therefore a criterion included in legislation regarding biomaterials testing. However, no consensus is yet available regarding appropriate complement-activation-related test parameters. We examined protein adsorption in plasma and complement activation/cytokine release in whole blood incubated with well-characterized polymers. Strong correlations were found between the ratio of C4 to its inhibitor C4BP and generation of 10 (mainly pro-inflammatory) cytokines, including IL-17, IFN-gamma, and IL-6. The levels of complement activation products correlated weakly (C3a) or not at all (C5a, sC5b-9), confirming their poor predictive values. We have demonstrated a direct correlation between downstream biological effects and the proteins initially adhering to an artificial surface after contact with blood. Consequently, we propose the C4/C4BP ratio as a robust, predictor of biocompatibility with superior specificity and sensitivity over the current gold standard. (C) 2014 Elsevier Ltd. All rights reserved.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Keyword
- Biomaterials
- C4 binding protein (C4BP)
- Complement
- Cytokines
- Inflammation
- In vitro screening
- Organic Chemistry
- Organisk kemi
- Biomedical Sciences
- Biomedicinsk vetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Engberg, Anna E.
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Nilsson, Per H.
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Huang, Shan
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Fromell, Karin
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Hamad, Osama A.
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Mollnes, Tom Eir ...
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show more...
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Rosengren-Holmbe ...
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Sandholm, Kersti ...
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Teramura, Yuji
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Nicholls, Ian A.
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Nilsson, Bo
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Nilsson Ekdahl, ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Immunology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomaterials Sci ...
- Articles in the publication
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Biomaterials
- By the university
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Linnaeus University
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Uppsala University