Sökning: WFRF:(Noble Charleston) > A fast and scalable...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 05075naa a2200493 4500 | |
001 | oai:lup.lub.lu.se:0049b0ec-50dd-4b0b-9655-3900f6b78258 | |
003 | SwePub | |
008 | 160401s2015 | |||||||||||000 ||eng| | |
009 | oai:gup.ub.gu.se/226302 | |
024 | 7 | a https://lup.lub.lu.se/record/53417832 URI |
024 | 7 | a https://doi.org/10.1371/journal.pone.01219052 DOI |
024 | 7 | a https://gup.ub.gu.se/publication/2263022 URI |
040 | a (SwePub)lud (SwePub)gu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Noble, Charlestonu Lund University,Lunds universitet,Fasta tillståndets fysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Beräkningsbiologi och biologisk fysik - Genomgår omorganisation,Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation,Naturvetenskapliga fakulteten,Solid State Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH,Computational Biology and Biological Physics - Undergoing reorganization,Department of Astronomy and Theoretical Physics - Undergoing reorganization,Faculty of Science4 aut0 (Swepub:lu)thep-can |
245 | 1 0 | a A fast and scalable kymograph alignment algorithm for nanochannel-based optical DNA mappings. |
264 | c 2015-04-13 | |
264 | 1 | b Public Library of Science (PLoS),c 2015 |
520 | a Optical mapping by direct visualization of individual DNA molecules, stretched in nanochannels with sequence-specific fluorescent labeling, represents a promising tool for disease diagnostics and genomics. An important challenge for this technique is thermal motion of the DNA as it undergoes imaging; this blurs fluorescent patterns along the DNA and results in information loss. Correcting for this effect (a process referred to as kymograph alignment) is a common preprocessing step in nanochannel-based optical mapping workflows, and we present here a highly efficient algorithm to accomplish this via pattern recognition. We compare our method with the one previous approach, and we find that our method is orders of magnitude faster while producing data of similar quality. We demonstrate proof of principle of our approach on experimental data consisting of melt mapped bacteriophage DNA. | |
650 | 7 | a NATURVETENSKAPx Fysikx Den kondenserade materiens fysik0 (SwePub)103042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Physical Sciencesx Condensed Matter Physics0 (SwePub)103042 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Biofysik0 (SwePub)106032 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biophysics0 (SwePub)106032 hsv//eng |
650 | 7 | a NATURVETENSKAPx Fysikx Annan fysik0 (SwePub)103992 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Physical Sciencesx Other Physics Topics0 (SwePub)103992 hsv//eng |
650 | 7 | a NATURVETENSKAPx Fysik0 (SwePub)1032 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Physical Sciences0 (SwePub)1032 hsv//eng |
650 | 7 | a NATURVETENSKAPx Data- och informationsvetenskap0 (SwePub)1022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Computer and Information Sciences0 (SwePub)1022 hsv//eng |
700 | 1 | a Nilsson, Adamu Lund University,Lunds universitet,Atomfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Atomic Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)fysi-adn |
700 | 1 | a Freitag, Camillau Gothenburg University,Göteborgs universitet,University of Gothenburg,Lund University,Institutionen för fysik (GU),Department of Physics (GU)4 aut |
700 | 1 | a Beech, Jasonu Lund University,Lunds universitet,Fasta tillståndets fysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Solid State Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)ftf-job |
700 | 1 | a Tegenfeldt, Jonasu Lund University,Lunds universitet,Fasta tillståndets fysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Solid State Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)ftf-jte |
700 | 1 | a Ambjörnsson, Tobiasu Lund University,Lunds universitet,Beräkningsbiologi och biologisk fysik - Genomgår omorganisation,Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation,Naturvetenskapliga fakulteten,Computational Biology and Biological Physics - Undergoing reorganization,Department of Astronomy and Theoretical Physics - Undergoing reorganization,Faculty of Science4 aut0 (Swepub:lu)thep-tar |
710 | 2 | a Fasta tillståndets fysikb Fysiska institutionen4 org |
773 | 0 | t PLoS ONEd : Public Library of Science (PLoS)g 10:4q 10:4x 1932-6203 |
856 | 4 | u http://dx.doi.org/10.1371/journal.pone.0121905x freey FULLTEXT |
856 | 4 | u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0121905&type=printable |
856 | 4 8 | u https://lup.lub.lu.se/record/5341783 |
856 | 4 8 | u https://doi.org/10.1371/journal.pone.0121905 |
856 | 4 8 | u https://gup.ub.gu.se/publication/226302 |
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