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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007096naa a2200577 4500
001oai:gup.ub.gu.se/301520
003SwePub
008240528s2021 | |||||||||||000 ||eng|
009oai:DiVA.org:oru-88531
009oai:DiVA.org:uu-450110
0247 a https://gup.ub.gu.se/publication/3015202 URI
0247 a https://doi.org/10.1001/jamaophthalmol.2020.58922 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-885312 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4501102 URI
040 a (SwePub)gud (SwePub)orud (SwePub)uu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Akerblom, H.u Department of Ophthalmology, Region Västmanland, Västerås, Sweden,Reg Vastmanland, Dept Ophthalmol, S-72189 Västerås, Sweden.4 aut
2451 0a Association of Gastric Bypass Surgery With Risk of Developing Diabetic Retinopathy Among Patients With Obesity and Type 2 Diabetes in Sweden: An Observational Study
264 1b American Medical Association (AMA),c 2021
520 a IMPORTANCE Knowledge of the incidence and progression of diabetic retinopathy (DR) after gastric bypass surgery (GBP) in patients with obesity and diabetes could guide the management of these patients. OBJECTIVE To investigate the incidence of diabetic ocular complications in patients with type 2 diabetes after GBP compared with the incidence of diabetic ocular complications in a matched cohort of patients with obesity and diabetes who have not undergone GBP. DESIGN, SETTING, AND PARTICIPANTS Data from 2 nationwide registers in Sweden, the Scandinavian Obesity Surgery Registry and the National Diabetes Register, were used for this cohort study. A total of 5321 patients with diabetes from the Scandinavian Obesity Surgery Registry who had undergone GBP from January 1, 2007, to December 31, 2013, were matched with 5321 patients with diabetes from the National Diabetes Register who had not undergone GBP, based on sex, age, body mass index (BMI), and calendar time (2007-2013). Follow-up data were obtained until December 31, 2015. Statistical analysis was performed from October 5, 2018, to September 30, 2019. EXPOSURE Gastric bypass surgery. MAIN OUTCOMES AND MEASURES Incidence of new DR and other diabetic ocular complications. RESULTS The study population consisted of 5321 patients who had undergone GBP (3223 women [60.6%]; mean [SD] age, 49.0 [9.5] years) and 5321 matched controls (3395 women [63.8%]; mean [SD] age, 47.1 [11.5] years). Mean (SD) follow-up was 4.5 (1.6) years. The mean (SD) BMI and hemoglobin A1c concentration at baseline were 42.0 (5.7) and 7.6%(1.5%), respectively, in the GBP group and 40.9 (7.3) and 7.5%(1.5%), respectively, in the control group. The mean (SD) duration of diabetes was 6.8 (6.3) years in the GBP group and 6.4 (6.4) years in the control group. The risk for new DR was reduced in the patients who underwent GBP (hazard ratio, 0.62 [95% CI, 0.49-0.78]; P <.001). The dominant risk factors for development of DR at baseline were diabetes duration, hemoglobin A1c concentration, use of insulin, glomerular filtration rate, and BMI. CONCLUSIONS AND RELEVANCE This nationwide matched cohort study suggests that there is a reduced risk of developing new DR associated with GBP, and no evidence of an increased risk of developing DR that threatened sight or required treatment. (c) 2021 American Medical Association. All rights reserved.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Oftalmologi0 (SwePub)302172 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Ophthalmology0 (SwePub)302172 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
653 a bariatric surgery
653 a cardiovascular outcomes
653 a progression
653 a complications
653 a remission
653 a mortality
653 a Ophthalmology
7001 a Franzén, Stefan,d 1967u Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,National Diabetes Register, Center of Registers, Gothenburg, Sweden; Health Metrics Unit, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Ctr Registers, Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Acad, Hlth Metr Unit, Gothenburg, Sweden.4 aut0 (Swepub:gu)xfrast
7001 a Zhou, C. D.u National Diabetes Register, Center of Registers, Gothenburg, Sweden,Ctr Registers, Gothenburg, Sweden.4 aut
7001 a Moren, A.u Department of Ophthalmology, Region Västmanland, Västerås, Sweden,Reg Vastmanland, Dept Ophthalmol, S-72189 Västerås, Sweden.4 aut
7001 a Ottosson, Johan,d 1957-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Surgery,Örebro Univ, Fac Med & Hlth, Dept Surg, Örebro, Sweden.4 aut0 (Swepub:oru)jhon
7001 a Sundbom, Magnusu Uppsala universitet,Gastrointestinalkirurgi4 aut0 (Swepub:uu)magsundb
7001 a Eliasson, Björn,d 1959u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden.4 aut0 (Swepub:gu)xelibj
7001 a Svensson, Ann-Marie,d 1961u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,National Diabetes Register, Center of Registers, Gothenburg, Sweden; Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden,Ctr Registers, Gothenburg, Sweden.;Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden.4 aut0 (Swepub:gu)xsannh
7001 a Granstam, Elisabet,d 1963-u Uppsala universitet,Centrum för klinisk forskning, Västerås,Reg Vastmanland, Dept Ophthalmol, S-72189 Västerås, Sweden.4 aut0 (Swepub:uu)elisgran
7102 a Department of Ophthalmology, Region Västmanland, Västerås, Swedenb Reg Vastmanland, Dept Ophthalmol, S-72189 Västerås, Sweden.4 org
7730 t Jama Ophthalmologyd : American Medical Association (AMA)g 139:2, s. 200-205q 139:2<200-205x 2168-6165x 2168-6173
8564 u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809612
8564 8u https://gup.ub.gu.se/publication/301520
8564 8u https://doi.org/10.1001/jamaophthalmol.2020.5892
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-88531
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-450110

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