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Sökning: WFRF:(Pejler Gunnar) > Obesity Is Associat...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005311naa a2200541 4500
001oai:DiVA.org:uu-502204
003SwePub
008230524s2023 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5022042 URI
0247 a https://doi.org/10.3390/ijms240868842 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Meen, Astri J.u UIT Arctic Univ Norway, Dept Med Biol, N-9019 Tromso, Norway.4 aut
2451 0a Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue
264 1b MDPI,c 2023
338 a electronic2 rdacarrier
520 a Proteoglycans are central components of the extracellular matrix (ECM) and binding partners for inflammatory chemokines. Morphological differences in the ECM and increased inflammation are prominent features of the white adipose tissues in patients with obesity. The impact of obesity and weight loss on the expression of specific proteoglycans in adipose tissue is not well known. This study aimed to investigate the relationship between adiposity and proteoglycan expression. We analyzed transcriptomic data from two human bariatric surgery cohorts. In addition, RT-qPCR was performed on adipose tissues from female and male mice fed a high-fat diet. Both visceral and subcutaneous adipose tissue depots were analyzed. Adipose mRNA expression of specific proteoglycans, proteoglycan biosynthetic enzymes, proteoglycan partner molecules, and other ECM-related proteins were altered in both human cohorts. We consistently observed more profound alterations in gene expression of ECM targets in the visceral adipose tissues after surgery (among others VCAN (p = 0.000309), OGN (p = 0.000976), GPC4 (p = 0.00525), COL1A1 (p = 0.00221)). Further, gene analyses in mice revealed sex differences in these two tissue compartments in obese mice. We suggest that adipose tissue repair is still in progress long after surgery, which may reflect challenges in remodeling increased adipose tissues. This study can provide the basis for more mechanistic studies on the role of proteoglycans in adipose tissues in obesity.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a extracellular matrix
653 a proteoglycans
653 a obesity
653 a inflammation
653 a adipose tissue
7001 a Doncheva, Atanaska I.u Univ Oslo, Dept Nutr, N-0316 Oslo, Norway.4 aut
7001 a Boettcher, Yvonneu Akershus Univ, Med Div, EpiGen, Hosp, N-1474 Nordbyhagen, Norway.;Akershus Univ Hosp, Dept Endocrinol, Div Med, N-1478 Lorenskog, Norway.4 aut
7001 a Dankel, Simon N.u Univ Bergen, Dept Clin Sci, Mohn Nutr Res Lab, N-5020 Bergen, Norway.;Haukeland Hosp, Dept Med Biochem & Pharmacol, Hormone Lab, N-5020 Bergen, Norway.4 aut
7001 a Hoffmann, Anneu Univ Leipzig, Helmholtz Inst Metab Obes & Vasc Res HI MAG, Helmholtz Zent Munchen, D-04103 Leipzig, Germany.;Univ Hosp Leipzig, D-04103 Leipzig, Germany.4 aut
7001 a Blueher, Matthiasu Univ Leipzig, Helmholtz Inst Metab Obes & Vasc Res HI MAG, Helmholtz Zent Munchen, D-04103 Leipzig, Germany.;Univ Hosp Leipzig, D-04103 Leipzig, Germany.;Univ Leipzig Med Ctr, Med Dept III Endocrinol Nephrol Rheumatol, D-04103 Leipzig, Germany.4 aut
7001 a Ferno, Johanu Univ Bergen, Dept Clin Sci, Mohn Nutr Res Lab, N-5020 Bergen, Norway.;Haukeland Hosp, Dept Med Biochem & Pharmacol, Hormone Lab, N-5020 Bergen, Norway.4 aut
7001 a Mellgren, Gunnaru Univ Bergen, Dept Clin Sci, Mohn Nutr Res Lab, N-5020 Bergen, Norway.;Haukeland Hosp, Dept Med Biochem & Pharmacol, Hormone Lab, N-5020 Bergen, Norway.4 aut
7001 a Ghosh, Adhidebu Univ Leipzig Med Ctr, Med Dept III Endocrinol Nephrol Rheumatol, D-04103 Leipzig, Germany.4 aut
7001 a Sun, Wenfeiu Swiss Fed Inst Technol, Inst Food Nutr & Hlth, CH-8092 Zurich, Switzerland.4 aut
7001 a Dong, Huau Swiss Fed Inst Technol, Inst Food Nutr & Hlth, CH-8092 Zurich, Switzerland.4 aut
7001 a Noe, Falkou Swiss Fed Inst Technol, Inst Food Nutr & Hlth, CH-8092 Zurich, Switzerland.4 aut
7001 a Wolfrum, Christianu Swiss Fed Inst Technol, Inst Food Nutr & Hlth, CH-8092 Zurich, Switzerland.4 aut
7001 a Pejler, Gunnaru Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi4 aut0 (Swepub:uu)gupej227
7001 a Dalen, Knut Tomasu Univ Oslo, Dept Nutr, N-0316 Oslo, Norway.4 aut
7001 a Kolset, Svein O.u Univ Oslo, Dept Nutr, N-0316 Oslo, Norway.4 aut
7102 a UIT Arctic Univ Norway, Dept Med Biol, N-9019 Tromso, Norway.b Univ Oslo, Dept Nutr, N-0316 Oslo, Norway.4 org
7730 t International Journal of Molecular Sciencesd : MDPIg 24:8q 24:8x 1661-6596x 1422-0067
8564 u https://doi.org/10.3390/ijms24086884y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1759015/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-502204
8564 8u https://doi.org/10.3390/ijms24086884

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