Sökning: WFRF:(Peralta C.) > (2020-2024) > The influence of th...
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000 | 05467naa a2200625 4500 | |
001 | oai:lup.lub.lu.se:cfc4d048-2b7a-4de1-afa0-5e47845469f9 | |
003 | SwePub | |
008 | 240506s2024 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/cfc4d048-2b7a-4de1-afa0-5e47845469f92 URI |
024 | 7 | a https://doi.org/10.1016/j.jinorgbio.2024.1125732 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Durigon, Daniele C.u Federal University of Santa Catarina4 aut |
245 | 1 0 | a The influence of thioether-substituted ligands in dicopper(II) complexes : Enhancing oxidation and biological activities |
264 | 1 | c 2024 |
520 | a This paper describes the synthesis, structural analysis, as well as the magnetic and spectroscopic characterizations of three new dicopper(II) complexes with dinucleating phenol-based ligands containing different thioether donor substituents: aromatic (1), aliphatic (2) or thiophene (3). Temperature-dependent magnetometry reveals the presence of antiferromagnetic coupling for 1 and 3 (J = −2.27 cm−1 and -5.01 cm−1, respectively, H = -2JS1S2) and ferromagnetic coupling for 2 (J = 5.72 cm−1). Broken symmetry DFT calculations attribute this behavior to a major contribution from the dz2 orbitals for 1 and 3, and from the dx2-y2 orbitals for 2, along with the p orbitals of the oxygens. The bioinspired catalytic activities of these complexes related to catechol oxidase were studied using 3,5-di-tert-butylcatechol as substrate. The order of catalytic rates for the substrate oxidation follows the trend 1 > 2 > 3 with kcat of (90.79 ± 2.90) × 10−3 for 1, (64.21 ± 0.99) × 10−3 for 2 and (14.20 ± 0.32) × 10−3 s−1 for 3. The complexes also cleave DNA through an oxidative mechanism with minor-groove preference, as indicated by experimental and molecular docking assays. Antimicrobial potential of these highly active complexes has shown that 3 inhibits both Staphylococcus aureus bacterium and Epidermophyton floccosum fungus. Notably, the complexes were found to be nontoxic to normal cells but exhibited cytotoxicity against epidermoid carcinoma cells, surpassing the activity of the metallodrug cisplatin. This research shows the multifaceted properties of these complexes, making them promising candidates for various applications in catalysis, nucleic acids research, and antimicrobial activities. | |
650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
650 | 7 | a NATURVETENSKAPx Kemix Fysikalisk kemi0 (SwePub)104022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Chemical Sciencesx Physical Chemistry0 (SwePub)104022 hsv//eng |
650 | 7 | a NATURVETENSKAPx Kemix Oorganisk kemi0 (SwePub)104042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Chemical Sciencesx Inorganic Chemistry0 (SwePub)104042 hsv//eng |
650 | 7 | a NATURVETENSKAPx Kemix Organisk kemi0 (SwePub)104052 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Chemical Sciencesx Organic Chemistry0 (SwePub)104052 hsv//eng |
653 | a Anticancer activity | |
653 | a Antimicrobial activity | |
653 | a Catecholase Activity | |
653 | a Dicopper(II) complexes | |
653 | a DNA cleavage | |
653 | a Thioether ligands | |
700 | 1 | a Glitz, Vinícius A.u Federal University of Santa Catarina4 aut |
700 | 1 | a Pimenta, Beatriz F.u Federal University of Santa Catarina4 aut |
700 | 1 | a Guedes, Anderson M.V.u Federal University of Rio de Janeiro4 aut |
700 | 1 | a Silva, João V.O.u State University of Maringá4 aut |
700 | 1 | a Bella Cruz, Catarina C.4 aut |
700 | 1 | a Andrade, Lídia M.u Federal University of Minas Gerais4 aut |
700 | 1 | a Pereira-Maia, Elene C.u Federal University of Minas Gerais4 aut |
700 | 1 | a Mikcha, Jane M.G.u State University of Maringá4 aut |
700 | 1 | a Bella Cruz, Alexandre4 aut |
700 | 1 | a Xavier, Fernando R.u State University Of Santa Catarina4 aut |
700 | 1 | a Terenzi, Hernán F.u Federal University of Santa Catarina4 aut |
700 | 1 | a Poneti, Giordanou Federal University of Rio de Janeiro,University of Tuscia4 aut |
700 | 1 | a Ribeiro, Ronny R.u Federal University of Paraná4 aut |
700 | 1 | a Nordlander, Ebbeu Lund University,Lunds universitet,Kemisk fysik,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,LU profilområde: Ljus och material,Lunds universitets profilområden,Chemical Physics,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,LU Profile Area: Light and Materials,Lund University Profile areas4 aut0 (Swepub:lu)ook1-eno |
700 | 1 | a Caramori, Giovanni F.u Federal University of Santa Catarina4 aut |
700 | 1 | a Bortoluzzi, Adailton J.u Federal University of Santa Catarina4 aut |
700 | 1 | a Peralta, Rosely A.u Federal University of Santa Catarina4 aut |
710 | 2 | a Federal University of Santa Catarinab Federal University of Rio de Janeiro4 org |
773 | 0 | t Journal of Inorganic Biochemistryg 256q 256x 0162-0134 |
856 | 4 | u http://dx.doi.org/10.1016/j.jinorgbio.2024.112573y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/cfc4d048-2b7a-4de1-afa0-5e47845469f9 |
856 | 4 8 | u https://doi.org/10.1016/j.jinorgbio.2024.112573 |
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