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Sökning: WFRF:(Phillips Andrew J.K.) > Causal Association ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005810naa a2200625 4500
001oai:gup.ub.gu.se/332699
003SwePub
008240910s2023 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:1959934b-fa64-4819-926d-d50b8143be72
0247 a https://gup.ub.gu.se/publication/3326992 URI
0247 a https://doi.org/10.1161/JAHA.122.0305682 DOI
0247 a https://lup.lub.lu.se/record/1959934b-fa64-4819-926d-d50b8143be722 URI
040 a (SwePub)gud (SwePub)lu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Goodman, Matthew O.u Brigham and Women's Hospital / Harvard Medical School,Broad Institute4 aut
2451 0a Causal Association Between Subtypes of Excessive Daytime Sleepiness and Risk of Cardiovascular Diseases
264 1c 2023
520 a BACKGROUND: Excessive daytime sleepiness (EDS), experienced in 10% to 20% of the population, has been associated with cardiovascular disease and death. However, the condition is heterogeneous and is prevalent in individuals having short and long sleep duration. We sought to clarify the relationship between sleep duration subtypes of EDS with cardiovascular outcomes, accounting for these subtypes. METHODS AND RESULTS: We defined 3 sleep duration subtypes of excessive daytime sleepiness: normal (6-9hours), short (<6hours), and long (>9hours), and compared these with a nonsleepy, normal-sleep-duration reference group. We analyzed their associations with incident myocardial infarction (MI) and stroke using medical records of 355901 UK Biobank participants and performed 2-sample Mendelian randomization for each outcome. Compared with healthy sleep, long-sleep EDS was associated with an 83% increased rate of MI (hazard ratio, 1.83 [95% CI, 1.21-2.77]) during 8.2-year median follow-up, adjusting for multiple health and sociodemographic factors. Mendelian randomization analysis provided supporting evidence of a causal role for a genetic long-sleep EDS subtype in MI (inverse-variance weighted β=1.995, P=0.001). In contrast, we did not find evidence that other subtypes of EDS were associated with incident MI or any associations with stroke (P>0.05). CONCLUSIONS: Our study suggests the previous evidence linking EDS with increased cardiovascular disease risk may be primarily driven by the effect of its long-sleep subtype on higher risk of MI. Underlying mechanisms remain to be investigated but may involve sleep irregularity and circadian disruption, suggesting a need for novel interventions in this population.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a cardiovascular diseases
653 a excessive daytime sleepiness subtypes
653 a Mendelian randomization
653 a prospective analysis
653 a sleep duration
7001 a Dashti, Hassan S.u Broad Institute,Massachusetts General Hospital4 aut
7001 a Lane, Jacqueline M.u Massachusetts General Hospital,Brigham and Women's Hospital / Harvard Medical School,Broad Institute4 aut
7001 a Windred, Daniel P.u Monash University4 aut
7001 a Burns, Angusu Massachusetts General Hospital,Monash University,Broad Institute4 aut
7001 a Jones, Samuel E.u University of Exeter,University of Helsinki4 aut
7001 a Sofer, Tamaru Brigham and Women's Hospital / Harvard Medical School,Harvard University4 aut
7001 a Purcell, Shaun M.u Brigham and Women's Hospital / Harvard Medical School,Broad Institute4 aut
7001 a Zhu, Xiaofengu Case Western Reserve University4 aut
7001 a Ollila, Hanna M.u Broad Institute,University of Helsinki,Massachusetts General Hospital4 aut
7001 a Kyle, Simon D.u University of Oxford4 aut
7001 a Spiegelhalder, Kai4 aut
7001 a Peker, Yüksel,d 1961u Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Brigham and Women's Hospital / Harvard Medical School,Sahlgrenska Academy,University of Pittsburgh4 aut0 (Swepub:lu)yu6542pe
7001 a Huang, Tianyiu Brigham and Women's Hospital / Harvard Medical School4 aut
7001 a Cain, Sean W.u Monash University4 aut
7001 a Phillips, Andrew J.K.u Monash University4 aut
7001 a Saxena, Richau Massachusetts General Hospital,Broad Institute4 aut
7001 a Rutter, Martin K.u University of Manchester,Manchester Academic Health Science Centre4 aut
7001 a Redline, Susanu Brigham and Women's Hospital / Harvard Medical School4 aut
7001 a Wang, Hemingu Broad Institute,Brigham and Women's Hospital / Harvard Medical School4 aut
7102 a Brigham and Women's Hospital / Harvard Medical Schoolb Broad Institute4 org
7730 t Journal of the American Heart Associationg 12:24q 12:24x 2047-9980
8564 u http://dx.doi.org/10.1161/JAHA.122.030568x freey FULLTEXT
8564 8u https://gup.ub.gu.se/publication/332699
8564 8u https://doi.org/10.1161/JAHA.122.030568
8564 8u https://lup.lub.lu.se/record/1959934b-fa64-4819-926d-d50b8143be72

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