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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04736naa a2200745 4500 | |
| 001 | oai:lup.lub.lu.se:1a6c1a35-7c9d-44fd-bbd7-aeeaa419be59 | |
| 003 | SwePub | |
| 008 | 160401s2006 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/4047932 URI |
| 024 | 7 | a https://doi.org/10.1002/mds.208082 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Schrag, A4 aut |
| 245 | 1 0 | a Health-related quality of life in multiple system atrophy |
| 264 | c 2006-02-24 | |
| 264 | 1 | b Wiley,c 2006 |
| 520 | a Although multiple system atrophy (MSA) is a neurodegenerative disorder leading to progressive disability and decreased life expectancy, little is known about patients' own evaluation of their illness and factors associated with poor health-related quality of life (Hr-QoL). We, therefore, assessed Hr-QoL and its determinants in MSA. The following scales were applied to 115 patients in the European MSA-Study Group (EMSA-SG) Natural History Study: Medical Outcome Study Short Form (SF-36), EQ-513, Beck Depression Inventory (BDI), Mini-Mental state examination (MMSE), Unified MSA Rating Scale (UMSARS), Hoehn & Yahr (H&Y) Parkinson's disease staging scale, Composite Autonomic Symptom Scale (COMPASS), and Parkinson's Disease Sleep Scale (PDSS). Forty-six percent of patients had moderate to severe depression (BDI >= 17); Hr-QoL scores on the SF-36 and EQ-5D were significantly impaired. Pain, the only domain with similar scores in MSA and published PD patients, was reported more frequently in patients with MSA-P (predominantly parkinsonian motor subtype) than MSA-C (predominantly cerebellar motor subtype; 76% vs. 50%; P = 0.005). Hr-QoL scores correlated most strongly with UMSARS motor, COMPASS, and BDI scores but not with MMSE scores, age at onset, or disease duration. The COMPASS and UMSARS activities of daily living scores were moderate-to-strong predictors for the SF-36 physical summary score and the BDI and UMSARS motor scores for the SF-36 mental summary score. This report is the first study to show that Hr-QoL is significantly impaired in MSA. Although not all possible factors related to impaired Hr-QoL in MSA could be assessed, autonomic dysfunction, motor impairment, and depression were most closely associated with poor Hr-QoL, and therapeutic management, therefore, should concentrate upon these aspects of the disease. (c) 2006 Movement Disorder Society. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 653 | a health-related quality of life | |
| 653 | a multiple system atrophy | |
| 653 | a autonomic dysfunction | |
| 653 | a depression | |
| 700 | 1 | a Geser, F4 aut |
| 700 | 1 | a Stampfer-Kountchev, M4 aut |
| 700 | 1 | a Seppi, K4 aut |
| 700 | 1 | a Sawires, M4 aut |
| 700 | 1 | a Kollensperger, M4 aut |
| 700 | 1 | a Scherfler, C4 aut |
| 700 | 1 | a Quinn, N4 aut |
| 700 | 1 | a Pellecchia, MT4 aut |
| 700 | 1 | a Barone, P4 aut |
| 700 | 1 | a del Sorbo, F4 aut |
| 700 | 1 | a Albanese, A4 aut |
| 700 | 1 | a Ostergaard, K4 aut |
| 700 | 1 | a Dupont, E4 aut |
| 700 | 1 | a Cardozo, A4 aut |
| 700 | 1 | a Tolosa, E4 aut |
| 700 | 1 | a Nilsson, C4 aut |
| 700 | 1 | a Widner, Håkanu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)mphy-hwi |
| 700 | 1 | a Lindvall, Olleu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)neur-oli |
| 700 | 1 | a Giladi, N4 aut |
| 700 | 1 | a Gurevich, T4 aut |
| 700 | 1 | a Daniels, C4 aut |
| 700 | 1 | a Deuschl, G4 aut |
| 700 | 1 | a Coelho, M4 aut |
| 700 | 1 | a Sampaio, C4 aut |
| 700 | 1 | a Abele, M4 aut |
| 700 | 1 | a Klockgether, T4 aut |
| 700 | 1 | a Schimke, N4 aut |
| 700 | 1 | a Eggert, KM4 aut |
| 700 | 1 | a Oertel, W4 aut |
| 700 | 1 | a Djaldetti, R4 aut |
| 700 | 1 | a Colosimo, C4 aut |
| 700 | 1 | a Meco, G4 aut |
| 700 | 1 | a Poewe, W4 aut |
| 700 | 1 | a Wenning, GK4 aut |
| 710 | 2 | a Neurologi, Lundb Sektion IV4 org |
| 773 | 0 | t Movement Disordersd : Wileyg 21:6, s. 809-815q 21:6<809-815x 0885-3185 |
| 856 | 4 | u http://dx.doi.org/10.1002/mds.20808y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/404793 |
| 856 | 4 8 | u https://doi.org/10.1002/mds.20808 |
Hitta mer i SwePub
- Av författaren/redakt...
- Schrag, A
- Geser, F
- Stampfer-Kountch ...
- Seppi, K
- Sawires, M
- Kollensperger, M
- visa fler...
- Scherfler, C
- Quinn, N
- Pellecchia, MT
- Barone, P
- del Sorbo, F
- Albanese, A
- Ostergaard, K
- Dupont, E
- Cardozo, A
- Tolosa, E
- Nilsson, C
- Widner, Håkan
- Lindvall, Olle
- Giladi, N
- Gurevich, T
- Daniels, C
- Deuschl, G
- Coelho, M
- Sampaio, C
- Abele, M
- Klockgether, T
- Schimke, N
- Eggert, KM
- Oertel, W
- Djaldetti, R
- Colosimo, C
- Meco, G
- Poewe, W
- Wenning, GK
- visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Neurologi
- Artiklar i publikationen
- Movement Disorde ...
- Av lärosätet
- Lunds universitet
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