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Epigenome-wide meta...
Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group
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- Jia, TY (author)
- Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.;Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai, Peoples R China.;Fudan Univ, MOE Key Lab Computat Neurosci & Brain Inspired In, Shanghai, Peoples R China.
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- Chu, CY (author)
- Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.
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- Liu, Y (author)
- Fudan Univ, Zhongshan Hosp, Sch Basic Med Sci, Dept Biochem & Mol Biol,MOE Key Lab Metab & Mol M, Shanghai, Peoples R China.
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show more...
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- van Dongen, J (author)
- Vrije Univ Amsterdam, Dept Biol Psychol, Van der Boechorststr 1, NL-1081 BT Amsterdam, Netherlands.,Univ New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia.
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- Papastergios, E (author)
- Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.
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- Armstrong, NJ (author)
- Murdoch Univ, Math & Stat, Perth, WA, Australia.,Univ Southern Calif, Keck Sch Med, Imaging Genet Ctr, Mark & Mary Stevens Neuroimaging & Informat Inst, Marina Del Rey, CA USA.
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- Bastin, ME (author)
- Univ Edinburgh MEB, Brain Res Imaging Ctr, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland.;Univ Edinburgh MEB, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.
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- Carrillo-Roa, T (author)
- Max Planck Inst Psychiat, Dept Translat Res Psychiat, Kraepelinstr 2-10, D-80804 Munich, Germany.
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- den Braber, A (author)
- Vrije Univ Amsterdam, Dept Biol Psychol, Van der Boechorststr 1, NL-1081 BT Amsterdam, Netherlands.
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- Harris, M (author)
- Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Edinburgh Imaging, Edinburgh, Midlothian, Scotland.
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- Jansen, R (author)
- Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
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- Liu, JY (author)
- Univ New Mexico, Dept Elect Engn, Albuquerque, NM 87131 USA.
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- Luciano, M (author)
- Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Dept Psychol, Edinburgh, Midlothian, Scotland.,Queensland Univ Technol, Sch Clin Sci, Herston Imaging Res Facil, Brisbane, Qld, Australia.
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- Ori, APS (author)
- Univ Calif Los Angeles, UCLA Ctr Neurobehav Genet, Los Angeles, CA USA.,Univ New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia.;Prince Wales Hosp, Neuropsychiat Inst, Sydney, NSW, Australia.,Indiana Univ Sch Med, Radiol & Imaging Sci, Indianapolis, IN 46202 USA.
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- Santianez, RR (author)
- Univ Cantabria, Univ Hosp Marques de Valdecilla, Sch Med, Dept Psychiat, Santander, Spain.;Ctr Invest Biomed Red Salud Mental, Santander, Spain.
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- Ruggeri, B (author)
- Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.
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- Sarkisyan, Daniil (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Shin, J (author)
- Univ Toronto, Hosp Sick Children, Toronto, ON, Canada.
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- Sungeun, K (author)
- Indiana Univ Sch Med, Ctr Neuroimaging, Dept Radiol & Imaging Sci, Indianapolis, IN 46202 USA.;Indiana Univ Sch Med, Ctr Computat Biol & Bioinformat, Indianapolis, IN 46202 USA.
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- Gutierrez, DT (author)
- Univ Cantabria, Univ Hosp Marques de Valdecilla, Sch Med, Dept Psychiat, Santander, Spain.;Valdecilla Biomed Res Inst IDIVAL, Neuroimaging Unit, Technol Facil, Santander, Cantabria, Spain.
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- van't Ent, D (author)
- Vrije Univ Amsterdam, Dept Biol Psychol, Van der Boechorststr 1, NL-1081 BT Amsterdam, Netherlands.
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- Ames, D (author)
- Natl Ageing Res Inst, Parkville, Vic, Australia.;Univ Melbourne, Acad Unit Psychiat Old Age, St Georges Hosp, Kew, Vic, Australia.
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- Artiges, E (author)
- Univ Paris 05, Inst Natl Sante & Rech Med, INSERM Unit 1000 Neuroimaging & Psychiat, Univ Paris Sud Paris Saclay, Orsay, France.;DIGITEO Labs, Gif Sur Yvette, France.;GH Nord Essonne Psychiat Dept 91G16, Orsay, France.
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- Bakalkin, Georgy (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Banaschewski, T (author)
- Heidelberg Univ, Dept Child & Adolescent Psychiat & Psychotherapy, Cent Inst Mental Hlth, Med Fac Mannheim, Sq J5, D-68159 Mannheim, Germany.
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- Bokde, ALW (author)
- Trinity Coll Dublin, Sch Med, Discipline Psychiat, Dublin, Ireland.;Trinity Coll Dublin, Trinity Inst Neurosci, Dublin, Ireland.,Univ New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia.
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- Brodaty, H (author)
- Univ New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia.;Univ New South Wales, Dementia Ctr Res Collaborat, Sch OfPsychiat, Sydney, NSW, Australia.
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- Bromberg, U (author)
- Univ Med Ctr Hamburg Eppendorf, House W34,3 OG,Martinistr 52, D-3 Hamburg, Germany.
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- Brouwer, R (author)
- Univ Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Utrecht, Netherlands.
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- Buchel, C (author)
- Univ Med Ctr Hamburg Eppendorf, House W34,3 OG,Martinistr 52, D-3 Hamburg, Germany.
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- Quinlan, EB (author)
- Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.
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- Cahn, W (author)
- Univ Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Utrecht, Netherlands.
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- de Zubicaray, GI (author)
- Queensland Univ Technol, Fac Hlth, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia.
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- Ehrlich, S (author)
- Tech Univ Dresden, Div Psychol & Social Med & Dev Neurosci, Fac Med, Dresden, Germany.
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- Ekstrom, TJ (author)
- Karolinska Institutet,Karolinska Univ Hosp, Ctr Mol Med, Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.,Univ Calif Los Angeles, UCLA Ctr Neurobehav Genet, Los Angeles, CA USA.;Univ Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Utrecht, Netherlands.,Univ New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia.;Univ New South Wales, Sch Psychiat, Dept Dev Disabil Neuropsychiat, Sydney, NSW, Australia.
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- Flor, H (author)
- Heidelberg Univ, Med Fac Mannheim, CentralInst Mental Hlth, Dept Cognit & Clin Neurosci, Sq J5, Mannheim, Germany.;Univ Mannheim, Sch Social Sci, Dept Psychol, D-68131 Mannheim, Germany.
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- Frohner, JH (author)
- Tech Univ Dresden, Dept Psychiat, Dresden, Germany.;Tech Univ Dresden, Neuroimaging Ctr, Dresden, Germany.,Univ Cape Town, Dept Psychiat, Cape Town, South Africa.;Univ Cape Town, Neurosci Inst, Cape Town, South Africa.
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- Frouin, V (author)
- Univ Paris Saclay, NeuroSpin, CEA, F-91191 Gif Sur Yvette, France.
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- Garavan, H (author)
- Univ Vermont, Dept Psychiat, Burlington, VT 05405 USA.
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- Gowland, P (author)
- Univ Nottingham, Sir Peter Mansfield Imaging Ctr, Sch Phys & Astron, Univ Pk, Nottingham, England.,Max Planck Inst Psychiat, Dept Translat Res Psychiat, Kraepelinstr 2-10, D-80804 Munich, Germany.
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- Heinz, A (author)
- Charite Univ Med Berlin, Freie Univ Berlin, Humboldt Univ Berlin, Berlin, Germany.;Berlin Inst Hlth, Dept Psychiat & Psychotherapy, Campus Charite Mitte, Charitepl 1, Berlin, Germany.
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Hoare, J (author)
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- Ittermann, B (author)
- Phys Tech Bundesanstalt PTB, Berlin, Germany.,Vrije Univ Amsterdam, Dept Biol Psychol, Van der Boechorststr 1, NL-1081 BT Amsterdam, Netherlands.
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Jahanshad, N (author)
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Jiang, JY (author)
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- Kwok, JB (author)
- Univ Sydney, Cent Clin Sch, Brain & Mind Ctr, Camperdown, NSW 2050, Australia.;Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia.
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- Martin, NG (author)
- QIMR Berghofer Med Res Inst, Genet Epidemiol, Brisbane, Qld, Australia.
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- Martinot, JL (author)
- Univ Paris 05, Inst Natl Sante & Rech Med, INSERM Unit 1000 Neuroimaging & Psychiat, Univ Paris Sud Paris Saclay, Orsay, France.;DIGITEO Labs, Gif Sur Yvette, France.;Cochin Hosp, Maison Solenn, Paris, France.
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- Mather, KA (author)
- Univ New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia.;Neurosci Res Australia, Sydney, NSW, Australia.
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McMahon, KL (author)
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- McRae, AF (author)
- Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
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- Nees, F (author)
- Heidelberg Univ, Dept Child & Adolescent Psychiat & Psychotherapy, Cent Inst Mental Hlth, Med Fac Mannheim, Sq J5, D-68159 Mannheim, Germany.;Heidelberg Univ, Med Fac Mannheim, CentralInst Mental Hlth, Dept Cognit & Clin Neurosci, Sq J5, Mannheim, Germany.
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- Orfanos, DP (author)
- Univ Paris Saclay, NeuroSpin, CEA, F-91191 Gif Sur Yvette, France.
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- Paus, T (author)
- Univ Toronto, Bloorview Res Inst, Holland Bloorview Kids Rehabil Hosp, Toronto, ON M6A 2E1, Canada.;Univ Toronto, Dept Psychol, Toronto, ON M6A 2E1, Canada.;Univ Toronto, Dept Psychiat, Toronto, ON M6A 2E1, Canada.,Univ Southern Calif, Keck Sch Med, Imaging Genet Ctr, Mark & Mary Stevens Neuroimaging & Informat Inst, Marina Del Rey, CA USA.
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- Poustka, L (author)
- Univ Med Ctr Gottingen, Dept Child & Adolescent Psychiat & Psychotherapy, von Siebold Str 5, D-37075 Gottingen, Germany.
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Samann, PG (author)
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- Schofield, PR (author)
- Neurosci Res Australia, Sydney, NSW, Australia.;Univ New South Wales, Fac Med, Sydney, NSW, Australia.
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- Smolka, MN (author)
- Tech Univ Dresden, Dept Psychiat, Dresden, Germany.;Tech Univ Dresden, Neuroimaging Ctr, Dresden, Germany.
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- Stein, DJ (author)
- Univ Cape Town, Dept Psychiat, Cape Town, South Africa.;Univ Cape Town, Neurosci Inst, Cape Town, South Africa.;SAMRC Unit Risk & Resilience Mental Disorders, Cape Town, South Africa.
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- Strike, LT (author)
- Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia.
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Teeuw, J (author)
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- Thalamuthu, A (author)
- Univ New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia.;Neurosci Res Australia, Sydney, NSW, Australia.
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Trollor, J (author)
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- Walter, H (author)
- Charite Univ Med Berlin, Freie Univ Berlin, Humboldt Univ Berlin, Berlin, Germany.;Berlin Inst Hlth, Dept Psychiat & Psychotherapy, Campus Charite Mitte, Charitepl 1, Berlin, Germany.
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- Wardlaw, JM (author)
- Univ Edinburgh, Brain Res Imaging Ctr, Ctr Clin Brain Sci, Edinburgh Dementia Res Ctr, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, UK Dementia Res Inst, Edinburgh, Midlothian, Scotland.
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Wen, W (author)
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- Whelan, R (author)
- Trinity Coll Dublin, Sch Psychol, Dublin, Ireland.;Trinity Coll Dublin, Global Brain Hlth Inst, Dublin, Ireland.
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- Apostolova, LG (author)
- Indiana Univ Sch Med, Dept Neurol, Indianapolis, IN 46202 USA.;Indiana Univ Sch Med, Dept Radiol & Imaging Sci, Indianapolis, IN 46202 USA.;Indiana Univ Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA.;Indiana Univ Sch Med, Indiana Alzheimer Dis Ctr, Indianapolis, IN 46202 USA.
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- Binder, EB (author)
- Max Planck Inst Psychiat, Dept Translat Res Psychiat, Kraepelinstr 2-10, D-80804 Munich, Germany.
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Boomsma, DI (author)
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- Calhoun, V (author)
- Univ New Mexico, Dept Elect Engn, Albuquerque, NM 87131 USA.;Emory Univ, Triinst Ctr Translat Res Neuroimaging & Data Sci, Atlanta, GA 30303 USA.
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- Crespo-Facorro, B (author)
- Univ Cantabria, Univ Hosp Marques de Valdecilla, Sch Med, Dept Psychiat, Santander, Spain.
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- Deary, IJ (author)
- Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Dept Psychol, Edinburgh, Midlothian, Scotland.
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- Pol, HH (author)
- Univ Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Utrecht, Netherlands.
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- Ophoff, RA (author)
- Univ Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Utrecht, Netherlands.;Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90024 USA.
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- Pausova, Z (author)
- Univ Toronto, Hosp Sick Children, Toronto, ON, Canada.
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Sachdev, PS (author)
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Saykin, A (author)
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- Wright, MJ (author)
- QIMR Berghofer Med Res Inst, Genet Epidemiol, Brisbane, Qld, Australia.
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Thompson, PM (author)
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- Schumann, G (author)
- Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.
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- Desrivieres, S (author)
- Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England.
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Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England;Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai, Peoples R China.;Fudan Univ, MOE Key Lab Computat Neurosci & Brain Inspired In, Shanghai, Peoples R China. Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England. (creator_code:org_t)
- 2019-12-06
- 2021
- English.
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In: Molecular psychiatry. - : Springer Science and Business Media LLC. - 1476-5578 .- 1359-4184. ; 26:8, s. 3884-3895
- Related links:
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https://www.nature.c...
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://kipublication...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues than brain, such as blood. A few studies of small sample sizes have revealed associations between blood DNA methylation and neuropsychopathology, however, large-scale epigenome-wide association studies (EWAS) are needed to investigate the utility of DNA methylation profiling as a peripheral marker for the brain. Here, in an analysis of eleven international cohorts, totalling 3337 individuals, we report epigenome-wide meta-analyses of blood DNA methylation with volumes of the hippocampus, thalamus and nucleus accumbens (NAcc)—three subcortical regions selected for their associations with disease and heritability and volumetric variability. Analyses of individual CpGs revealed genome-wide significant associations with hippocampal volume at two loci. No significant associations were found for analyses of thalamus and nucleus accumbens volumes. Cluster-based analyses revealed additional differentially methylated regions (DMRs) associated with hippocampal volume. DNA methylation at these loci affected expression of proximal genes involved in learning and memory, stem cell maintenance and differentiation, fatty acid metabolism and type-2 diabetes. These DNA methylation marks, their interaction with genetic variants and their impact on gene expression offer new insights into the relationship between epigenetic variation and brain structure and may provide the basis for biomarker discovery in neurodegeneration and neuropsychiatric conditions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Jia, TY
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Chu, CY
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Liu, Y
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van Dongen, J
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Papastergios, E
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Armstrong, NJ
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show more...
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Bastin, ME
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Carrillo-Roa, T
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den Braber, A
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Harris, M
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Jansen, R
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Liu, JY
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Luciano, M
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Ori, APS
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Santianez, RR
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Ruggeri, B
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Sarkisyan, Danii ...
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Shin, J
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Sungeun, K
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Gutierrez, DT
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van't Ent, D
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Ames, D
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Artiges, E
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Bakalkin, Georgy
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Banaschewski, T
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Bokde, ALW
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Brodaty, H
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Bromberg, U
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Brouwer, R
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Buchel, C
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Quinlan, EB
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Cahn, W
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de Zubicaray, GI
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Ehrlich, S
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Ekstrom, TJ
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Flor, H
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Frohner, JH
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Frouin, V
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Garavan, H
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Gowland, P
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Heinz, A
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Hoare, J
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Ittermann, B
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Jahanshad, N
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Jiang, JY
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Kwok, JB
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Martin, NG
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Martinot, JL
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Mather, KA
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McMahon, KL
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McRae, AF
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Nees, F
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Orfanos, DP
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Paus, T
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Poustka, L
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Samann, PG
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Schofield, PR
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Smolka, MN
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Stein, DJ
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Strike, LT
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Teeuw, J
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Thalamuthu, A
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Trollor, J
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Walter, H
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Wardlaw, JM
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Wen, W
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Whelan, R
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Apostolova, LG
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Binder, EB
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Boomsma, DI
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Calhoun, V
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Crespo-Facorro, ...
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Deary, IJ
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Pol, HH
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Ophoff, RA
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Pausova, Z
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Sachdev, PS
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Saykin, A
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Wright, MJ
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Thompson, PM
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Schumann, G
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Desrivieres, S
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Molecular psychi ...
- By the university
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Karolinska Institutet
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Uppsala University