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  • Gillving, Cecilia,1999-Örebro universitet,Institutionen för medicinska vetenskaper,Faculty of Medicine and Health, University Health Care Research Centre, Örebro University, Örebro, Sweden,Orebro Univ, Sweden (författare)

Seizure Duration and Electroconvulsive Therapy in Major Depressive Disorder

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • AMER MEDICAL ASSOC,2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-206304
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-206304URI
  • https://doi.org/10.1001/jamanetworkopen.2024.22738DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-115389URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:239052292URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:159155951URI
  • https://gup.ub.gu.se/publication/340530URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|Region Orebro County ALF; Nyckelfonden at Orebro University Hospital
  • IMPORTANCE Electroconvulsive therapy (ECT), wherein a generalized epileptic seizure is induced, is a treatment for major depressive disorder (MDD). Currently, it is unclear whether there is an association between seizure length and treatment outcome. OBJECTIVE To explore the association between seizure duration, potential confounding variables, and ECT treatment outcome. DESIGN, SETTING, AND PARTICIPANTS This population-based cohort study obtained data from the Swedish National Quality Register for ECT. Patients treated for unipolar MDD with unilateral electrode placement between January 1, 2012, and December 31, 2019, were included. The electroencephalographic (EEG) seizure duration from the first ECT treatment session for each patient was used for analysis. Data analyses were performed between March 2021 and May 2024. MAIN OUTCOMES AND MEASURESThe primary outcome was remission, defined as a cutoff score of less than 10 points on the self-assessment version of the Montgomery-& Aring;sberg Depression Rating Scale within 1 week after ECT. Multivariate logistic regression analysis was performed to calculate odds ratios (ORs) between different seizure duration groups. Furthermore, the associations between concomitant use of pharmacological treatments, seizure duration, and remission rate were explored. RESULTS Among the 6998 patients included, 4229 (60.4%) were female and the mean (SD) age was 55.2 (18.6) years. Overall, 2749 patients (39.3%) achieved remission after ECT. Patients with EEG seizure duration of 60 to 69 seconds had the highest remission rates compared with patients with seizure duration of less than 20 seconds (OR, 2.17; 95% CI, 1.63-2.88; P < .001). Anticonvulsant medications were associated with shorter seizure duration (eg, lamotrigine: beta coefficient [SE], -6.02 [1.08]; P < .001) and lower remission rates (eg, lamotrigine: adjusted OR, 0.67; 95% CI, 0.53-0.84; P < .001). CONCLUSIONS AND RELEVANCE This study found an association between seizure length and remission from MDD. Use of anticonvulsant medication during ECT was associated with shorter seizure duration and lower remission rates after ECT.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ekman, Carl JohanKarolinska Inst, Sweden; Stockholm Hlth Care Serv, Sweden,Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Stockholm Health Care Services, Stockholm, Sweden (författare)
  • Hammar, AsaUniv Bergen, Norway; Lund Univ, Sweden,Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway; Department of Clinical Sciences, Division of Adult Psychiatry Faculty of Medicine, Lund University, Lund, Sweden (författare)
  • Landén, Mikael,1966Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xlandt (författare)
  • Lundberg, JohanKarolinska Institutet (författare)
  • Rad, Pouya MovahedLund Univ, Sweden,Department of Clinical Sciences, Division of Adult Psychiatry Faculty of Medicine, Lund University, Lund, Sweden (författare)
  • Nordanskog, PiaLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken i Linköping,Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden; Department of Psychiatry, Region Östergötland, Linköping, Sweden(Swepub:liu)piano33 (författare)
  • von Knorring, LarsUppsala Univ, Sweden,Department of Medical Sciences, Psychiatry, Uppsala University, Uppsala, Sweden (författare)
  • Nordenskjöld, Axel,1977-Örebro universitet,Institutionen för medicinska vetenskaper,Faculty of Medicine and Health, University Health Care Research Centre, Örebro University, Örebro, Sweden,Orebro Univ, Sweden(Swepub:oru)alnd (författare)
  • Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:JAMA Network Open: AMER MEDICAL ASSOC7:72574-3805

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