SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Rao Melacini P)
 

Sökning: WFRF:(Rao Melacini P) > Urinary Sodium and ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004941naa a2200817 4500
001oai:gup.ub.gu.se/308385
003SwePub
008240528s2021 | |||||||||||000 ||eng|
024a https://gup.ub.gu.se/publication/3083852 URI
024a https://doi.org/10.1093/ajh/hpaa1762 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Judge, C.4 aut
2451 0a Urinary Sodium and Potassium, and Risk of Ischemic and Hemorrhagic Stroke (INTERSTROKE): A Case-Control Study
264 c 2020-11-16
264 1b Oxford University Press (OUP),c 2021
520 a BACKGROUND Although low sodium intake (<2 g/day) and high potassium intake (>3.5 g/day) are proposed as public health interventions to reduce stroke risk, there is uncertainty about the benefit and feasibility of this combined recommendation on prevention of stroke. METHODS We obtained random urine samples from 9,275 cases of acute first stroke and 9,726 matched controls from 27 countries and estimated the 24-hour sodium and potassium excretion, a surrogate for intake, using the Tanaka formula. Using multivariable conditional logistic regression, we determined the associations of estimated 24-hour urinary sodium and potassium excretion with stroke and its subtypes. RESULTS Compared with an estimated urinary sodium excretion of 2.8-3.5 g/ day (reference), higher (>4.26 g/day) (odds ratio [OR] 1.81; 95% confidence interval [CI], 1.65-2.00) and lower (<2.8 g/day) sodium excretion (OR 1.39; 95% CI, 1.26-1.53) were significantly associated with increased risk of stroke. The stroke risk associated with the highest quartile of sodium intake (sodium excretion >4.26 g/day) was significantly greater (P < 0.001) for intracerebral hemorrhage (ICH) (OR 2.38; 95% CI, 1.93-2.92) than for ischemic stroke (OR 1.67; 95% CI, 1.50-1.87). Urinary potassium was inversely and linearly associated with risk of stroke, and stronger for ischemic stroke than ICH (P = 0.026). In an analysis of combined sodium and potassium excretion, the combination of high potassium intake (>1.58 g/day) and moderate sodium intake (2.8-3.5 g/day) was associated with the lowest risk of stroke. CONCLUSIONS The association of sodium intake and stroke is J-shaped, with high sodium intake a stronger risk factor for ICH than ischemic stroke. Our data suggest that moderate sodium intake-rather than low sodium intake-combined with high potassium intake may be associated with the lowest risk of stroke and expected to be a more feasible combined dietary target.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653 a blood pressure
653 a hypertension
653 a intracerebral hemorrhage
653 a ischemic stroke
653 a potassium
653 a sodium
653 a stroke
700a O'Donnell, M. J.4 aut
700a Hankey, G. J.4 aut
700a Rangarajan, S.4 aut
700a Chin, S. L.4 aut
700a Rao-Melacini, P.4 aut
700a Ferguson, J.4 aut
700a Smyth, A.4 aut
700a Xavier, D.4 aut
700a Liu, L. S.4 aut
700a Zhang, H. Y.4 aut
700a Lopez-Jaramillo, P.4 aut
700a Damasceno, A.4 aut
700a Langhorne, P.4 aut
700a Rosengren, Annika,d 1951u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xrosan
700a Dans, A. L.4 aut
700a Elsayed, A.4 aut
700a Avezum, A.4 aut
700a Mondo, C.4 aut
700a Ryglewicz, D.4 aut
700a Czlonkowska, A.4 aut
700a Pogosova, N.4 aut
700a Weimar, C.4 aut
700a Diaz, R.4 aut
700a Yusoff, K.4 aut
700a Yusufali, A.4 aut
700a Oguz, A.4 aut
700a Wang, X. Y.4 aut
700a Lanas, F.4 aut
700a Ogah, O. S.4 aut
700a Ogunniyi, A.4 aut
700a Iversen, H. K.4 aut
700a Malaga, G.4 aut
700a Rumboldt, Z.4 aut
700a Oveisgharan, S.4 aut
700a Al Hussain, F.4 aut
700a Yusuf, S.4 aut
700a Interstroke Investigators, Interstroke Investigators4 aut
710a Göteborgs universitetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org
773t American Journal of Hypertensiond : Oxford University Press (OUP)g 34:4, s. 414-425q 34:4<414-425x 0895-7061x 1941-7225
856u https://academic.oup.com/ajh/article-pdf/34/4/414/37197858/hpaa176.pdf
8564 8u https://gup.ub.gu.se/publication/308385
8564 8u https://doi.org/10.1093/ajh/hpaa176

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy