WFRF:(Rose Zerilli M.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03568naa a2200577 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:142618034 | |
| 003 | SwePub | |
| 008 | 240701s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1426180342 URI |
| 024 | 7 | a https://doi.org/10.1182/bloodadvances.20190002372 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Wojdacz, TK4 aut |
| 245 | 1 0 | a Clinical significance of DNA methylation in chronic lymphocytic leukemia patients: results from 3 UK clinical trials |
| 264 | c 2019-08-21 | |
| 264 | 1 | b American Society of Hematology,c 2019 |
| 520 | a Chronic lymphocytic leukemia patients with mutated immunoglobulin heavy-chain genes (IGHV-M), particularly those lacking poor-risk genomic lesions, often respond well to chemoimmunotherapy (CIT). DNA methylation profiling can subdivide early-stage patients into naive B-cell–like CLL (n-CLL), memory B-cell–like CLL (m-CLL), and intermediate CLL (i-CLL), with differing times to first treatment and overall survival. However, whether DNA methylation can identify patients destined to respond favorably to CIT has not been ascertained. We classified treatment-naive patients (n = 605) from 3 UK chemo and CIT clinical trials into the 3 epigenetic subgroups, using pyrosequencing and microarray analysis, and performed expansive survival analysis. The n-CLL, i-CLL, and m-CLL signatures were found in 80% (n = 245/305), 17% (53/305), and 2% (7/305) of IGHV-unmutated (IGHV-U) cases, respectively, and in 9%, (19/216), 50% (108/216), and 41% (89/216) of IGHV-M cases, respectively. Multivariate Cox proportional analysis identified m-CLL as an independent prognostic factor for overall survival (hazard ratio [HR], 0.46; 95% confidence interval [CI], 0.24-0.87; P = .018) in CLL4, and for progression-free survival (HR, 0.25; 95% CI, 0.10-0.57; P = .002) in ARCTIC and ADMIRE patients. The analysis of epigenetic subgroups in patients entered into 3 first-line UK CLL trials identifies m-CLL as an independent marker of prolonged survival and may aid in the identification of patients destined to demonstrate prolonged survival after CIT. | |
| 700 | 1 | a Amarasinghe, HE4 aut |
| 700 | 1 | a Kadalayil, L4 aut |
| 700 | 1 | a Beattie, A4 aut |
| 700 | 1 | a Forster, J4 aut |
| 700 | 1 | a Blakemore, SJ4 aut |
| 700 | 1 | a Parker, H4 aut |
| 700 | 1 | a Bryant, D4 aut |
| 700 | 1 | a Larrayoz, M4 aut |
| 700 | 1 | a Clifford, R4 aut |
| 700 | 1 | a Robbe, P4 aut |
| 700 | 1 | a Davis, ZA4 aut |
| 700 | 1 | a Else, M4 aut |
| 700 | 1 | a Howard, DR4 aut |
| 700 | 1 | a Stamatopoulos, B4 aut |
| 700 | 1 | a Steele, AJ4 aut |
| 700 | 1 | a Rosenquist, Ru Karolinska Institutet4 aut |
| 700 | 1 | a Collins, A4 aut |
| 700 | 1 | a Pettitt, AR4 aut |
| 700 | 1 | a Hillmen, P4 aut |
| 700 | 1 | a Plass, C4 aut |
| 700 | 1 | a Schuh, A4 aut |
| 700 | 1 | a Catovsky, D4 aut |
| 700 | 1 | a Oscier, DG4 aut |
| 700 | 1 | a Rose-Zerilli, MJJ4 aut |
| 700 | 1 | a Oakes, CC4 aut |
| 700 | 1 | a Strefford, JC4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Blood advancesd : American Society of Hematologyg 3:16, s. 2474-2481q 3:16<2474-2481x 2473-9537x 2473-9529 |
| 856 | 4 | u https://ashpublications.org/bloodadvances/article-pdf/3/16/2474/1554611/advancesadv2019000237.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:142618034 |
| 856 | 4 8 | u https://doi.org/10.1182/bloodadvances.2019000237 |
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- Kadalayil, L
- Beattie, A
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- Parker, H
- Bryant, D
- Larrayoz, M
- Clifford, R
- Robbe, P
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- Else, M
- Howard, DR
- Stamatopoulos, B
- Steele, AJ
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