Harnessing Selectivity and Sensitivity in Electronic Biosensing: A Novel Lab-on-Chip Multigate Organic Transistor

Parkula, Vitaliy (författare): Univ Modena & Reggio Emilia, Italy; Scriba Nanotecnol Srl, Italy

Diacci, Chiara (författare): Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten,Univ Modena & Reggio Emilia, Italy

Patrahau, Bianca (författare): Univ Modena & Reggio Emilia, Italy; Univ Strasbourg, France

Di Lauro, Michele (författare): Univ Modena & Reggio Emilia, Italy; Ist Italiano Tecnol, Italy

Biscarini, Fabio (författare): Univ Modena & Reggio Emilia, Italy; Ist Italiano Tecnol, Italy

(creator_code:org_t)

2020-06-02
2020
Engelska.
Ingår i: Analytical Chemistry. - : AMER CHEMICAL SOC. - 0003-2700 .- 1520-6882. ; 92:13, s. 9330-9337

Relaterad länk:: https://pubs.acs.org...; visa fler...; https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

Abstract Ämnesord

Stäng

Electrolyte gated organic transistors can operate as powerful ultrasensitive biosensors, and efforts are currently devoted to devising strategies for reducing the contribution of hardly avoidable, nonspecific interactions to their response, to ultimately harness selectivity in the detection process. We report a novel lab-on-a-chip device integrating a multigate electrolyte gated organic field-effect transistor (EGOFET) with a 6.5 mu L microfluidics set up capable to provide an assessment of both the response reproducibility, by enabling measurement in triplicate, and of the device selectivity through the presence of an internal reference electrode. As proof-of-concept, we demonstrate the efficient operation of our pentacene based EGOFET sensing platform through the quantification of tumor necrosis factor alpha with a detection limit as low as 3 pM. Sensing of inflammatory cytokines, which also include TNF alpha, is of the outmost importance for monitoring a large number of diseases. The multiplexable organic electronic lab-on-chip provides a statistically solid, reliable, and selective response on microliters sample volumes on the minutes time scale, thus matching the relevant key-performance indicators required in point-of-care diagnostics.

Av författaren/redakt...: Parkula, Vitaliy; Berto, Marcello; Diacci, Chiara; Patrahau, Bianca; Di Lauro, Michel ...; Kovtun, Alessand ...; visa fler...; Liscio, Andrea; Sensi, Matteo; Samori, Paolo; Greco, Pierpaolo; Bortolotti, Carl ...; Biscarini, Fabio; visa färre...

Om ämnet

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.