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Highly Reduced Surv...
Highly Reduced Survival in Essential Thrombocythemia and Polycythemia Vera Patients with Vascular Complications during Follow-up
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- Ahlstrand, Erik, 1974- (författare)
- Örebro University,Region Örebro län,Örebro universitet, Institutionen för medicinska vetenskaper,Department of Medicine,Orebro Univ, Sweden
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- Samuelsson, Jan (författare)
- Department of Hematology, University Hospital Linköping, Linköping, Sweden,Region Östergötland, Hematologiska kliniken US
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- Lindgren, Marie (författare)
- Department of Medicine, Kalmar County Hospital, Sweden,Kalmar Cty Hosp, Sweden
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- Pettersson, Helna (författare)
- Division of Hematology, Specialist Medicine, NU Hospital Group, Uddevalla, Sweden,NU Hosp Grp, Sweden
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- Liljeholm, Maria (författare)
- Department of Hematology, University Hospital of Northern Sweden, Umeå, Sweden,Norrland University Hospital,Univ Hosp Nouthern Sweden, Sweden
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- Ravn-Landtblom, Anna (författare)
- Karolinska Institutet,Stockholm South General Hospital,Karolinska Inst, Sweden; Stockholm South Hosp, Sweden
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- Scheding, Stefan (författare)
- Lund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Benmärgsstamceller och cellulära terapier,Forskargrupper vid Lunds universitet,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Bone marrow stem cells and cellular therapies,Lund University Research Groups,Skåne University Hospital,Lund Univ, Sweden; Skane Univ Hosp, Sweden
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- Andréasson, Björn (författare)
- Division of Hematology, Specialist Medicine, NU Hospital Group, Uddevalla, Sweden,NU Hosp Grp, Sweden
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(creator_code:org_t)
- 2020-01-28
- 2020
- Engelska.
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Ingår i: European Journal of Haematology. - : Munksgaard Forlag. - 0902-4441 .- 1600-0609. ; 104:3, s. 271-278
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To explore the relative importance of risk factors, treatments and blood counts for the occurrence of vascular complications and their impact on life expectancy in Essential Thrombocythemia (ET) and Polycythemia Vera (PV).METHODS: Nested case-control study within the Swedish MPN registry. From a cohort of 922 ET patients and 763 PV patients, 71 ET and 81 PV cases with vascular complications were compared to matched controls.RESULTS: Incidence of vascular complications were 2.0 and 3.4 events per 100 patient-years in ET and PV, respectively. At diagnosis, no significant risk factor differences were observed between cases and controls in neither of the diseases. At the time of vascular event, ET complication cases did not differ significantly from controls but in PV, cases had significantly higher WBCs and were to a lesser extent treated with antithrombotic and cytoreductive therapy. Life expectancy was significantly decreased in both ET and PV cases compared to controls.CONCLUSIONS: The risk of vascular complications is high in both ET and PV and these complications have a considerable impact on life expectancy. The protective effect of antithrombotic and cytoreductive therapy for vascular complications in PV underscores the importance of avoiding undertreatment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Essential Thrombocythemia
- Myeloproliferative neoplasms
- Polycythemia Vera
- essential thrombocythemia
- myeloproliferative neoplasms
- polycythemia vera
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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