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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 17011naa a2202929 4500 | |
| 001 | oai:gup.ub.gu.se/321350 | |
| 003 | SwePub | |
| 008 | 240528s2022 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:oru-97171 | |
| 009 | oai:lup.lub.lu.se:bcd4db38-4bed-4703-bdc8-c37368962136 | |
| 009 | oai:prod.swepub.kib.ki.se:148745137 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3213502 URI |
| 024 | 7 | a https://doi.org/10.1001/jamaneurol.2021.52162 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-971712 URI |
| 024 | 7 | a https://lup.lub.lu.se/record/bcd4db38-4bed-4703-bdc8-c373689621362 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1487451372 URI |
| 040 | a (SwePub)gud (SwePub)orud (SwePub)lud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Jansen, Willemijn Ju Alzheimer Centre Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands; Banner Alzheimer's Institute, Phoenix, Arizona, USA4 aut |
| 245 | 1 0 | a Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum. |
| 264 | 1 | b American Medical Association (AMA),c 2022 |
| 500 | a Funding Agency:Biogen | |
| 520 | a One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid aggregation, which can be detected by biomarkers in cerebrospinal fluid (CSF) and on positron emission tomography (PET) scans. Prevalence estimates of amyloid pathology are important for health care planning and clinical trial design.To estimate the prevalence of amyloid abnormality in persons with normal cognition, subjective cognitive decline, mild cognitive impairment, or clinical AD dementia and to examine the potential implications of cutoff methods, biomarker modality (CSF or PET), age, sex, APOE genotype, educational level, geographical region, and dementia severity for these estimates.This cross-sectional, individual-participant pooled study included participants from 85 Amyloid Biomarker Study cohorts. Data collection was performed from January 1, 2013, to December 31, 2020. Participants had normal cognition, subjective cognitive decline, mild cognitive impairment, or clinical AD dementia. Normal cognition and subjective cognitive decline were defined by normal scores on cognitive tests, with the presence of cognitive complaints defining subjective cognitive decline. Mild cognitive impairment and clinical AD dementia were diagnosed according to published criteria.Alzheimer disease biomarkers detected on PET or in CSF.Amyloid measurements were dichotomized as normal or abnormal using cohort-provided cutoffs for CSF or PET or by visual reading for PET. Adjusted data-driven cutoffs for abnormal amyloid were calculated using gaussian mixture modeling. Prevalence of amyloid abnormality was estimated according to age, sex, cognitive status, biomarker modality, APOE carrier status, educational level, geographical location, and dementia severity using generalized estimating equations.Among the 19097 participants (mean [SD] age, 69.1 [9.8] years; 10148 women [53.1%]) included, 10139 (53.1%) underwent an amyloid PET scan and 8958 (46.9%) had an amyloid CSF measurement. Using cohort-provided cutoffs, amyloid abnormality prevalences were similar to 2015 estimates for individuals without dementia and were similar across PET- and CSF-based estimates (24%; 95% CI, 21%-28%) in participants with normal cognition, 27% (95% CI, 21%-33%) in participants with subjective cognitive decline, and 51% (95% CI, 46%-56%) in participants with mild cognitive impairment, whereas for clinical AD dementia the estimates were higher for PET than CSF (87% vs 79%; mean difference, 8%; 95% CI, 0%-16%; P=.04). Gaussian mixture modeling-based cutoffs for amyloid measures on PET scans were similar to cohort-provided cutoffs and were not adjusted. Adjusted CSF cutoffs resulted in a 10% higher amyloid abnormality prevalence than PET-based estimates in persons with normal cognition (mean difference, 9%; 95% CI, 3%-15%; P=.004), subjective cognitive decline (9%; 95% CI, 3%-15%; P=.005), and mild cognitive impairment (10%; 95% CI, 3%-17%; P=.004), whereas the estimates were comparable in persons with clinical AD dementia (mean difference, 4%; 95% CI, -2% to 9%; P=.18).This study found that CSF-based estimates using adjusted data-driven cutoffs were up to 10% higher than PET-based estimates in people without dementia, whereas the results were similar among people with dementia. This finding suggests that preclinical and prodromal AD may be more prevalent than previously estimated, which has important implications for clinical trial recruitment strategies and health care planning policies. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 653 | a Aged | |
| 653 | a Alzheimer Disease | |
| 653 | a cerebrospinal fluid | |
| 653 | a diagnostic imaging | |
| 653 | a epidemiology | |
| 653 | a Amyloid beta-Peptides | |
| 653 | a cerebrospinal fluid | |
| 653 | a Amyloidogenic Proteins | |
| 653 | a Amyloidosis | |
| 653 | a Apolipoproteins E | |
| 653 | a genetics | |
| 653 | a Biomarkers | |
| 653 | a cerebrospinal fluid | |
| 653 | a Cognitive Dysfunction | |
| 653 | a diagnostic imaging | |
| 653 | a epidemiology | |
| 653 | a Cross-Sectional Studies | |
| 653 | a Female | |
| 653 | a Humans | |
| 653 | a Male | |
| 653 | a Middle Aged | |
| 653 | a Peptide Fragments | |
| 653 | a cerebrospinal fluid | |
| 653 | a Positron-Emission Tomography | |
| 653 | a Prevalence | |
| 653 | a tau Proteins | |
| 653 | a cerebrospinal fluid | |
| 700 | 1 | a Janssen, Olinu Alzheimer Centre Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands4 aut |
| 700 | 1 | a Tijms, Betty Mu Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam University Medical Center (UMC), Amsterdam, the Netherlands4 aut |
| 700 | 1 | a Vos, Stephanie J Bu Alzheimer Centre Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands4 aut |
| 700 | 1 | a Ossenkoppele, Riku Karolinska Institutet,Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)ri1513os |
| 700 | 1 | a Visser, Pieter Jelleu Karolinska Institutet,Vrije Universiteit Amsterdam,Maastricht University4 aut |
| 700 | 1 | a Aarsland, Dag4 aut |
| 700 | 1 | a Alcolea, Daniel4 aut |
| 700 | 1 | a Altomare, Daniele4 aut |
| 700 | 1 | a von Arnim, Christine4 aut |
| 700 | 1 | a Baiardi, Simone4 aut |
| 700 | 1 | a Baldeiras, Ines4 aut |
| 700 | 1 | a Barthel, Henryk4 aut |
| 700 | 1 | a Bateman, Randall J4 aut |
| 700 | 1 | a Van Berckel, Bart4 aut |
| 700 | 1 | a Binette, Alexa Pichet4 aut |
| 700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
| 700 | 1 | a Boada, Merce4 aut |
| 700 | 1 | a Boecker, Henning4 aut |
| 700 | 1 | a Bottlaender, Michel4 aut |
| 700 | 1 | a den Braber, Anouk4 aut |
| 700 | 1 | a Brooks, David J4 aut |
| 700 | 1 | a Van Buchem, Mark A4 aut |
| 700 | 1 | a Camus, Vincent4 aut |
| 700 | 1 | a Carill, Jose Manuel4 aut |
| 700 | 1 | a Cerman, Jiri4 aut |
| 700 | 1 | a Chen, Kewei4 aut |
| 700 | 1 | a Chételat, Gaël4 aut |
| 700 | 1 | a Chipi, Elena4 aut |
| 700 | 1 | a Cohen, Ann D4 aut |
| 700 | 1 | a Daniels, Alisha4 aut |
| 700 | 1 | a Delarue, Marion4 aut |
| 700 | 1 | a Didic, Mira4 aut |
| 700 | 1 | a Drzezga, Alexander4 aut |
| 700 | 1 | a Dubois, Bruno4 aut |
| 700 | 1 | a Eckerström, Marieu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut |
| 700 | 1 | a Ekblad, Laura L4 aut |
| 700 | 1 | a Engelborghs, Sebastiaan4 aut |
| 700 | 1 | a Epelbaum, Stéphane4 aut |
| 700 | 1 | a Fagan, Anne M4 aut |
| 700 | 1 | a Fan, Yong4 aut |
| 700 | 1 | a Fladby, Tormod4 aut |
| 700 | 1 | a Fleisher, Adam S4 aut |
| 700 | 1 | a Van der Flier, Wiesje M4 aut |
| 700 | 1 | a Förster, Stefan4 aut |
| 700 | 1 | a Fortea, Juan4 aut |
| 700 | 1 | a Frederiksen, Kristian Steen4 aut |
| 700 | 1 | a Freund-Levi, Yvonne,d 1956-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet Center for Alzheimer Research, Stockholm, Sweden; Department of Old Age Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom,Amyloid Biomarker Study Group4 aut0 (Swepub:oru)yfi |
| 700 | 1 | a Frings, Lars4 aut |
| 700 | 1 | a Frisoni, Giovanni B4 aut |
| 700 | 1 | a Fröhlich, Lutz4 aut |
| 700 | 1 | a Gabryelewicz, Tomasz4 aut |
| 700 | 1 | a Gertz, Hermann-Josef4 aut |
| 700 | 1 | a Gill, Kiran Dip4 aut |
| 700 | 1 | a Gkatzima, Olymbia4 aut |
| 700 | 1 | a Gómez-Tortosa, Estrella4 aut |
| 700 | 1 | a Grimmer, Timo4 aut |
| 700 | 1 | a Guedj, Eric4 aut |
| 700 | 1 | a Habeck, Christian G4 aut |
| 700 | 1 | a Hampel, Harald4 aut |
| 700 | 1 | a Handels, Ron4 aut |
| 700 | 1 | a Hansson, Oskar4 aut |
| 700 | 1 | a Hausner, Lucrezia4 aut |
| 700 | 1 | a Hellwig, Sabine4 aut |
| 700 | 1 | a Heneka, Michael T4 aut |
| 700 | 1 | a Herukka, Sanna-Kaisa4 aut |
| 700 | 1 | a Hildebrandt, Helmut4 aut |
| 700 | 1 | a Hodges, John4 aut |
| 700 | 1 | a Hort, Jakub4 aut |
| 700 | 1 | a Huang, Chin-Chang4 aut |
| 700 | 1 | a Iriondo, Ane Juaristi4 aut |
| 700 | 1 | a Itoh, Yoshiaki4 aut |
| 700 | 1 | a Ivanoiu, Adrian4 aut |
| 700 | 1 | a Jagust, William J4 aut |
| 700 | 1 | a Jessen, Frank4 aut |
| 700 | 1 | a Johannsen, Peter4 aut |
| 700 | 1 | a Johnson, Keith A4 aut |
| 700 | 1 | a Kandimalla, Ramesh4 aut |
| 700 | 1 | a Kapaki, Elisabeth N4 aut |
| 700 | 1 | a Kern, Silkeu Gothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centre for Ageing and Health (Agecap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xkersi |
| 700 | 1 | a Kilander, Lena4 aut |
| 700 | 1 | a Klimkowicz-Mrowiec, Aleksandra4 aut |
| 700 | 1 | a Klunk, William E4 aut |
| 700 | 1 | a Koglin, Norman4 aut |
| 700 | 1 | a Kornhuber, Johannes4 aut |
| 700 | 1 | a Kramberger, Milica G4 aut |
| 700 | 1 | a Kuo, Hung-Chou4 aut |
| 700 | 1 | a Van Laere, Koen4 aut |
| 700 | 1 | a Landau, Susan M4 aut |
| 700 | 1 | a Landeau, Brigitte4 aut |
| 700 | 1 | a Lee, Dong Young4 aut |
| 700 | 1 | a de Leon, Mony4 aut |
| 700 | 1 | a Leyton, Cristian E4 aut |
| 700 | 1 | a Lin, Kun-Ju4 aut |
| 700 | 1 | a Lleó, Alberto4 aut |
| 700 | 1 | a Löwenmark, Malin4 aut |
| 700 | 1 | a Madsen, Karine4 aut |
| 700 | 1 | a Maier, Wolfgang4 aut |
| 700 | 1 | a Marcusson, Jan4 aut |
| 700 | 1 | a Marquié, Marta4 aut |
| 700 | 1 | a Martinez-Lage, Pablo4 aut |
| 700 | 1 | a Maserejian, Nancy4 aut |
| 700 | 1 | a Mattsson, Niklas4 aut |
| 700 | 1 | a de Mendonça, Alexandre4 aut |
| 700 | 1 | a Meyer, Philipp T4 aut |
| 700 | 1 | a Miller, Bruce L4 aut |
| 700 | 1 | a Minatani, Shinobu4 aut |
| 700 | 1 | a Mintun, Mark A4 aut |
| 700 | 1 | a Mok, Vincent C T4 aut |
| 700 | 1 | a Molinuevo, Jose Luis4 aut |
| 700 | 1 | a Morbelli, Silvia Daniela4 aut |
| 700 | 1 | a Morris, John C4 aut |
| 700 | 1 | a Mroczko, Barbara4 aut |
| 700 | 1 | a Na, Duk L4 aut |
| 700 | 1 | a Newberg, Andrew4 aut |
| 700 | 1 | a Nobili, Flavio4 aut |
| 700 | 1 | a Nordberg, Agneta4 aut |
| 700 | 1 | a Olde Rikkert, Marcel G M4 aut |
| 700 | 1 | a de Oliveira, Catarina Resende4 aut |
| 700 | 1 | a Olivieri, Pauline4 aut |
| 700 | 1 | a Orellana, Adela4 aut |
| 700 | 1 | a Paraskevas, George4 aut |
| 700 | 1 | a Parchi, Piero4 aut |
| 700 | 1 | a Pardini, Matteo4 aut |
| 700 | 1 | a Parnetti, Lucilla4 aut |
| 700 | 1 | a Peters, Oliver4 aut |
| 700 | 1 | a Poirier, Judes4 aut |
| 700 | 1 | a Popp, Julius4 aut |
| 700 | 1 | a Prabhakar, Sudesh4 aut |
| 700 | 1 | a Rabinovici, Gil D4 aut |
| 700 | 1 | a Ramakers, Inez H4 aut |
| 700 | 1 | a Rami, Lorena4 aut |
| 700 | 1 | a Reiman, Eric M4 aut |
| 700 | 1 | a Rinne, Juha O4 aut |
| 700 | 1 | a Rodrigue, Karen M4 aut |
| 700 | 1 | a Rodríguez-Rodriguez, Eloy4 aut |
| 700 | 1 | a Roe, Catherine M4 aut |
| 700 | 1 | a Rosa-Neto, Pedro4 aut |
| 700 | 1 | a Rosen, Howard J4 aut |
| 700 | 1 | a Rot, Uros4 aut |
| 700 | 1 | a Rowe, Christopher C4 aut |
| 700 | 1 | a Rüther, Eckart4 aut |
| 700 | 1 | a Ruiz, Agustín4 aut |
| 700 | 1 | a Sabri, Osama4 aut |
| 700 | 1 | a Sakhardande, Jayant4 aut |
| 700 | 1 | a Sánchez-Juan, Pascual4 aut |
| 700 | 1 | a Sando, Sigrid Botne4 aut |
| 700 | 1 | a Santana, Isabel4 aut |
| 700 | 1 | a Sarazin, Marie4 aut |
| 700 | 1 | a Scheltens, Philip4 aut |
| 700 | 1 | a Schröder, Johannes4 aut |
| 700 | 1 | a Selnes, Per4 aut |
| 700 | 1 | a Seo, Sang Won4 aut |
| 700 | 1 | a Silva, Dina4 aut |
| 700 | 1 | a Skoog, Ingmar,d 1954u Gothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centre for Ageing and Health (Agecap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xskooi |
| 700 | 1 | a Snyder, Peter J4 aut |
| 700 | 1 | a Soininen, Hilkka4 aut |
| 700 | 1 | a Sollberger, Marc4 aut |
| 700 | 1 | a Sperling, Reisa A4 aut |
| 700 | 1 | a Spiru, Luisa4 aut |
| 700 | 1 | a Stern, Yaakov4 aut |
| 700 | 1 | a Stomrud, Erik4 aut |
| 700 | 1 | a Takeda, Akitoshi4 aut |
| 700 | 1 | a Teichmann, Marc4 aut |
| 700 | 1 | a Teunissen, Charlotte E4 aut |
| 700 | 1 | a Thompson, Louisa I4 aut |
| 700 | 1 | a Tomassen, Jori4 aut |
| 700 | 1 | a Tsolaki, Magda4 aut |
| 700 | 1 | a Vandenberghe, Rik4 aut |
| 700 | 1 | a Verbeek, Marcel M4 aut |
| 700 | 1 | a Verhey, Frans R J4 aut |
| 700 | 1 | a Villemagne, Victor4 aut |
| 700 | 1 | a Villeneuve, Sylvia4 aut |
| 700 | 1 | a Vogelgsang, Jonathan4 aut |
| 700 | 1 | a Waldemar, Gunhild4 aut |
| 700 | 1 | a Wallin, Åsau Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Centre for Ageing and Health (Agecap),Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)med-was |
| 700 | 1 | a Wallin, Åsa K4 aut |
| 700 | 1 | a Wiltfang, Jens4 aut |
| 700 | 1 | a Wolk, David A4 aut |
| 700 | 1 | a Yen, Tzu-Chen4 aut |
| 700 | 1 | a Zboch, Marzena4 aut |
| 700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
| 710 | 2 | a Alzheimer Centre Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands; Banner Alzheimer's Institute, Phoenix, Arizona, USAb Alzheimer Centre Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands4 org |
| 710 | 2 | a Amyloid Biomarker Study Group |
| 773 | 0 | t JAMA neurologyd : American Medical Association (AMA)g 79:3, s. 228-243q 79:3<228-243x 2168-6157x 2168-6149 |
| 856 | 4 | u http://dx.doi.org/10.1001/jamaneurol.2021.5216y FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/321350 |
| 856 | 4 8 | u https://doi.org/10.1001/jamaneurol.2021.5216 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-97171 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/bcd4db38-4bed-4703-bdc8-c37368962136 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:148745137 |
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- Cerman, Jiri
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- Morris, John C
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- Selnes, Per
- Seo, Sang Won
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- Snyder, Peter J
- Soininen, Hilkka
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- Spiru, Luisa
- Stern, Yaakov
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