WFRF:(Shi Fei)
Sökning: WFRF:(Shi Fei) > Gut microbiota medi...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04748naa a2200649 4500 | |
| 001 | oai:research.chalmers.se:a4eb037a-4f83-49cf-b954-a12d21083f72 | |
| 003 | SwePub | |
| 008 | 200304s2020 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://doi.org/10.1038/s41467-020-14676-42 DOI |
| 024 | 7 | a https://research.chalmers.se/publication/5156892 URI |
| 040 | a (SwePub)cth | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Liu, Zhigangu Northwest A&F university4 aut |
| 245 | 1 0 | a Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment |
| 264 | c 2020-02-18 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2020 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Cognitive decline is one of the complications of type 2 diabetes (T2D). Intermittent fasting (IF) is a promising dietary intervention for alleviating T2D symptoms, but its protective effect on diabetes-driven cognitive dysfunction remains elusive. Here, we find that a 28-day IF regimen for diabetic mice improves behavioral impairment via a microbiota-metabolites-brain axis: IF enhances mitochondrial biogenesis and energy metabolism gene expression in hippocampus, re-structures the gut microbiota, and improves microbial metabolites that are related to cognitive function. Moreover, strong connections are observed between IF affected genes, microbiota and metabolites, as assessed by integrative modelling. Removing gut microbiota with antibiotics partly abolishes the neuroprotective effects of IF. Administration of 3-indolepropionic acid, serotonin, short chain fatty acids or tauroursodeoxycholic acid shows a similar effect to IF in terms of improving cognitive function. Together, our study purports the microbiota-metabolites-brain axis as a mechanism that can enable therapeutic strategies against metabolism-implicated cognitive pathophysiologies. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Annan klinisk medicin0 (SwePub)302992 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Other Clinical Medicine0 (SwePub)302992 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 700 | 1 | a Dai, Xiaoshuangu BGI Institute of Applied Agriculture4 aut |
| 700 | 1 | a Zhang, Hongbou Northwest A&F university4 aut |
| 700 | 1 | a Shi, Renjieu Northwest A&F university4 aut |
| 700 | 1 | a Hui, Yanu BGI Institute of Applied Agriculture,Köpenhamns universitet,University of Copenhagen4 aut |
| 700 | 1 | a Jin, Xinu BGI Institute of Applied Agriculture4 aut |
| 700 | 1 | a Zhang, Wentongu Northwest A&F university4 aut |
| 700 | 1 | a Wang, Luanfengu Northwest A&F university4 aut |
| 700 | 1 | a Wang, Qianxuu Northwest A&F university4 aut |
| 700 | 1 | a Wang, Dannau Northwest A&F university4 aut |
| 700 | 1 | a Wang, Jiau Northwest A&F university4 aut |
| 700 | 1 | a Tan, Xintongu Northwest A&F university4 aut |
| 700 | 1 | a Ren, Bou Northwest A&F university4 aut |
| 700 | 1 | a Liu, Xiaoningu Northwest A&F university4 aut |
| 700 | 1 | a Zhao, Tongu Northwest A&F university4 aut |
| 700 | 1 | a Wang, Jiaminu Northwest A&F university4 aut |
| 700 | 1 | a Pan, Junruu Northwest A&F university4 aut |
| 700 | 1 | a Yuan, Tianu Northwest A&F university4 aut |
| 700 | 1 | a Chu, Chuanqiu Northwest A&F university4 aut |
| 700 | 1 | a Lan, Leiu BGI Institute of Applied Agriculture4 aut |
| 700 | 1 | a Yin, Feiu University of Arizona4 aut |
| 700 | 1 | a Cadenas, Enriqueu University of Southern California4 aut |
| 700 | 1 | a Shi, Lin,d 1988u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)shlin |
| 700 | 1 | a Zhao, Shancenu BGI Institute of Applied Agriculture4 aut |
| 700 | 1 | a Liu, Xuebou Northwest A&F university4 aut |
| 710 | 2 | a Northwest A&F universityb BGI Institute of Applied Agriculture4 org |
| 773 | 0 | t Nature Communicationsd : Springer Science and Business Media LLCg 11:1, s. 855-q 11:1<855-x 2041-1723x 2041-1723 |
| 856 | 4 | u https://research.chalmers.se/publication/515689/file/515689_Fulltext.pdfx primaryx freey FULLTEXT |
| 856 | 4 | u https://www.nature.com/articles/s41467-020-14676-4.pdf |
| 856 | 4 8 | u https://doi.org/10.1038/s41467-020-14676-4 |
| 856 | 4 8 | u https://research.chalmers.se/publication/515689 |
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