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Neurotensin acceler...
Neurotensin accelerates atherosclerosis and increases circulating levels of short-chain and saturated triglycerides
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- Li, Jing (författare)
- University of Kentucky
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- Yang, Liping (författare)
- University of Kentucky
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- Song, Jun (författare)
- University of Kentucky
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- Yan, Baoxiang (författare)
- University of Kentucky
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- Morris, Andrew J. (författare)
- University of Arkansas for Medical Sciences
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- Moseley, Hunter (författare)
- University of Kentucky
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- Flight, Robert (författare)
- University of Kentucky
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- Wang, Chi (författare)
- University of Kentucky
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- Liu, Jinpeng (författare)
- University of Kentucky
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- Weiss, Heidi L. (författare)
- University of Kentucky
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- Morris, Edward F. (författare)
- Washington University in St. Louis
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Abdelhamid, Ilyes (författare)
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Gerl, Mathias J. (författare)
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- Melander, Olle (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Smyth, Susan (författare)
- University of Arkansas for Medical Sciences
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- Evers, B. Mark (författare)
- University of Kentucky
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(creator_code:org_t)
- Engelska.
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Ingår i: Atherosclerosis. - 0021-9150.
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background and aims: Obesity and type 2 diabetes are significant risk factors for atherosclerotic cardiovascular disease (CVD) worldwide, but the underlying pathophysiological links are poorly understood. Neurotensin (NT), a 13-amino-acid hormone peptide, facilitates intestinal fat absorption and contributes to obesity in mice fed a high-fat diet. Elevated levels of pro-NT (a stable NT precursor produced in equimolar amounts relative to NT) are associated with obesity, type 2 diabetes, and CVD in humans. Whether NT is a causative factor in CVD is unknown. Methods: Nt+/+ and Nt–/– mice were either injected with adeno-associated virus encoding PCSK9 mutants or crossed with Ldlr–/– mice and fed a Western diet. Atherosclerotic plaques were analyzed by en face analysis, Oil Red O and CD68 staining. In humans, we evaluated the association between baseline pro-NT and growth of carotid bulb thickness after 16.4 years. Lipidomic profiles were analyzed. Results: Atherosclerotic plaque formation is attenuated in Nt-deficient mice through mechanisms that are independent of reductions in circulating cholesterol and triglycerides but associated with remodeling of the plasma triglyceride pool. An increasing plasma concentration of pro-NT predicts atherosclerotic events in coronary and cerebral arteries independent of all major traditional risk factors, indicating a strong link between NT and atherosclerosis. This plasma lipid profile analysis confirms the association of pro-NT with remodeling of the plasma triglyceride pool in atherosclerotic events. Conclusions: Our findings are the first to directly link NT to increased atherosclerosis and indicate the potential role for NT in preventive and therapeutic strategies for CVD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Heart disease
- High-fat diet
- Neurotensin
- Obesity
- Small intestine
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Li, Jing
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Yang, Liping
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Song, Jun
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Yan, Baoxiang
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Morris, Andrew J ...
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Moseley, Hunter
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visa fler...
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Flight, Robert
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Wang, Chi
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Liu, Jinpeng
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Weiss, Heidi L.
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Morris, Edward F ...
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Abdelhamid, Ilye ...
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Gerl, Mathias J.
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Melander, Olle
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Smyth, Susan
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Evers, B. Mark
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Atherosclerosis
- Av lärosätet
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Lunds universitet