WFRF:(Suh Alexander)
Sökning: WFRF:(Suh Alexander) > (2011-2014) > The genome of a Mes...
The genome of a Mesozoic paleovirus reveals the evolution of hepatitis B viruses
-
- Suh, Alexander (författare)
- Uppsala universitet,Evolutionsbiologi
- Brosius, Juergen (författare)
- Schmitz, Juergen (författare)
- visa fler...
- Kriegs, Jan Ole (författare)
- visa färre...
- (creator_code:org_t)
- 2013-04-30
- 2013
- Engelska.
- Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 4, s. 1791-
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Paleovirology involves the identification of ancient endogenous viral elements within eukaryotic genomes. The evolutionary origins of the reverse-transcribing hepatitis B viruses, however, remain elusive, due to the small number of endogenized sequences present in host genomes. Here we report a comprehensively dated genomic record of hepatitis B virus endogenizations that spans bird evolution from > 82 to < 12.1 million years ago. The oldest virus relic extends over a 99% complete hepatitis B virus genome sequence and constitutes the first discovery of a Mesozoic paleovirus genome. We show that Hepadnaviridae are 463 million years older than previously known and provide direct evidence for coexistence of hepatitis B viruses and birds during the Mesozoic and Cenozoic Eras. Finally, phylogenetic analyses and distribution of hepatitis B virus relics suggest that birds potentially are the ancestral hosts of Hepadnaviridae and mammalian hepatitis B viruses probably emerged after a bird-mammal host switch. Our study reveals previously undiscovered and multi-faceted insights into prehistoric hepatitis B virus evolution and provides valuable resources for future studies, such as in-vitro resurrection of Mesozoic hepadnaviruses.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta mer i SwePub
- Av författaren/redakt...
- Suh, Alexander
- Brosius, Juergen
- Schmitz, Juergen
- Kriegs, Jan Ole
- Artiklar i publikationen
- Nature Communica ...
- Av lärosätet
- Uppsala universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
