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WFRF:(Sveinsdóttir Snjólaug)
 

Sökning: WFRF:(Sveinsdóttir Snjólaug) > The heme and radica...

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FältnamnIndikatorerMetadata
00006484naa a2200517 4500
001oai:lup.lub.lu.se:b8a2fb87-e10d-4ccc-b14e-aac5dfdd9b49
003SwePub
008190627s2019 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/b8a2fb87-e10d-4ccc-b14e-aac5dfdd9b492 URI
0247 a https://doi.org/10.1186/s12974-019-1486-42 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Romantsik, Olgau Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neonatologi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neonatology,Lund University Research Groups4 aut0 (Swepub:lu)med-oar
2451 0a The heme and radical scavenger α1-microglobulin (A1M) confers early protection of the immature brain following preterm intraventricular hemorrhage
264 c 2019-06-07
264 1b Springer Science and Business Media LLC,c 2019
520 a Background: Germinal matrix intraventricular hemorrhage (GM-IVH) is associated with cerebro-cerebellar damage in very preterm infants, leading to neurodevelopmental impairment. Penetration, from the intraventricular space, of extravasated red blood cells and extracellular hemoglobin (Hb), to the periventricular parenchyma and the cerebellum has been shown to be causal in the development of brain injury following GM-IVH. Furthermore, the damage has been described to be associated with the cytotoxic nature of extracellular Hb-metabolites. To date, there is no therapy available to prevent infants from developing either hydrocephalus or serious neurological disability. Mechanisms previously described to cause brain damage following GM-IVH, i.e., oxidative stress and Hb-metabolite toxicity, suggest that the free radical and heme scavenger α1-microglobulin (A1M) may constitute a potential neuroprotective intervention. Methods: Using a preterm rabbit pup model of IVH, where IVH was induced shortly after birth in pups delivered by cesarean section at E29 (3 days prior to term), we investigated the brain distribution of recombinant A1M (rA1M) following intracerebroventricular (i.c.v.) administration at 24 h post-IVH induction. Further, short-term functional protection of i.c.v.-administered human A1M (hA1M) following IVH in the preterm rabbit pup model was evaluated. Results: Following i.c.v. administration, rA1M was distributed in periventricular white matter regions, throughout the fore- and midbrain and extending to the cerebellum. The regional distribution of rA1M was accompanied by a high co-existence of positive staining for extracellular Hb. Administration of i.c.v.-injected hA1M was associated with decreased structural tissue and mitochondrial damage and with reduced mRNA expression for proinflammatory and inflammatory signaling-related genes induced by IVH in periventricular brain tissue. Conclusions: The results of this study indicate that rA1M/hA1M is a potential candidate for neuroprotective treatment following preterm IVH.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
653 a Damage to the immature brain
653 a Hemoglobin
653 a Intraventricular hemorrhage
653 a Oxidative stress
653 a α-microglobulin
7001 a Agyemang, Alex Aduseiu Lund University,Lunds universitet,Neonatologi,Forskargrupper vid Lunds universitet,Neonatology,Lund University Research Groups4 aut0 (Swepub:lu)med-aua
7001 a Sveinsdóttir, Snjolaugu Lund University4 aut0 (Swepub:lu)med-sus
7001 a Rutardóttir, Sigurbjörgu Lund University4 aut0 (Swepub:lu)med-srr
7001 a Holmqvist, Bou ImaGene-iT AB4 aut0 (Swepub:lu)zool-bho
7001 a Cinthio, Magnusu Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)elma-mpe
7001 a Mörgelin, Mattiasu Lund University4 aut0 (Swepub:lu)medk-mmn
7001 a Gumus, Gulcinu University of Barcelona4 aut
7001 a Karlsson, Helenau A1M Pharma AB4 aut0 (Swepub:lu)he4542ka
7001 a Hansson, Stefan R.u Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)gyn-sha
7001 a Åkerström, Bou Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)medk-bak
7001 a Ley, Davidu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neonatologi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neonatology,Lund University Research Groups4 aut0 (Swepub:lu)pedi-dle
7001 a Gram, Magnusu Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Antioxidationsmedicin,Forskargrupper vid Lunds universitet,Neonatologi,Sjukdomsorsakande oxidation,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Antioxidation medicine,Lund University Research Groups,Neonatology,Redox Medicine,A1M Pharma AB4 aut0 (Swepub:lu)medk-mo0
7102 a Pediatrik, Lundb Sektion V4 org
7730 t Journal of Neuroinflammationd : Springer Science and Business Media LLCg 16:1q 16:1x 1742-2094
8564 u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554963/x freey FULLTEXT
8564 u http://dx.doi.org/10.1186/s12974-019-1486-4x freey FULLTEXT
8564 u https://jneuroinflammation.biomedcentral.com/track/pdf/10.1186/s12974-019-1486-4
8564 8u https://lup.lub.lu.se/record/b8a2fb87-e10d-4ccc-b14e-aac5dfdd9b49
8564 8u https://doi.org/10.1186/s12974-019-1486-4

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