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  • Thastrup, MariaUniv Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark. (author)

Flow cytometric detection of leukemic blasts in cerebrospinal fluid predicts risk of relapse in childhood acute lymphoblastic leukemia : a Nordic Society of Pediatric Hematology and Oncology study

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2019-09-18
  • Springer Nature,2020
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-409713
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-409713URI
  • https://doi.org/10.1038/s41375-019-0570-1DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Correction in: Leukemia (epub 2020). DOI: https://doi.org/10.1038/s41375-020-0821-1
  • Central nervous system (CNS) involvement by cytospin is associated with increased risk of relapse in childhood acute lymphoblastic leukemia. We investigated if flow cytometric analysis of cerebrospinal fluid (CSF) at diagnosis improves the prediction of relapse. This prospective cohort study included patients (1.0-17.9 years) treated according to the Nordic Society of Pediatric Hematology and Oncology ALL2008 protocol. CSF flow cytometry samples were obtained at 17 centers, preserved with Transfix (R), and analyzed at a central laboratory. One-hundred and seventy-one (25.4%) of 673 patients were positive by flow cytometry (CNSflow+). The 4-year cumulative incidence of relapse was higher for patients with cytospin positivity (CNScyto+) (17.1% vs. 7.5%), CNSflow+ (16.5% vs. 5.6%), and cytospin and/or flow positivity (CNScomb+) (16.7% vs. 5.1%). In Cox regression analysis stratified by immunophenotype and minimal residual disease day 29 and adjusted by sex, predictors of relapse were age (hazard ratio [HR] 1.1, 95% CI 1.1-1.2, P < 0.001), white blood cell count at diagnosis (HR 1.4, 95% CI 1.1-1.6, P < 0.001), and CNScomb+ (HR 2.2, 95% CI 1.0-4.7, P = 0.042). Flow cytometric analysis of CSF improves detection of CNS leukemia, distinguishes patients with high and low risk of relapse, and may improve future risk stratification and CNS-directed therapy.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Marquart, Hanne VibekeUniv Copenhagen, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark. (author)
  • Levinsen, MetteUniv Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark. (author)
  • Grell, KathrineUniv Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.;Univ Copenhagen, Dept Publ Hlth, Sect Biostat, Copenhagen, Denmark. (author)
  • Abrahamsson, JonasSahlgrens Univ Hosp, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden. (author)
  • Albertsen, Birgitte KlugAarhus Univ Hosp, Children & Adolescent Hlth, Aarhus, Denmark. (author)
  • Frandsen, Thomas LethUniv Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark. (author)
  • Harila-Saari, Arja H.Uppsala universitet,Barnneurologi/Barnonkologi(Swepub:uu)arjha456 (author)
  • Lähteenmäki, Päivi MariaTurku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland.;Turku Univ, Turku, Finland. (author)
  • Niinimäki, RiittaUniv Oulu, Oulu Univ Hosp, Dept Pediat, Oulu, Finland.;Univ Oulu, PEDEGO Res Unit, Oulu, Finland. (author)
  • Pronk, Cornelis JanSkane Univ Hosp, Dept Pediat, Lund, Sweden. (author)
  • Ulvmoen, AinaOslo Univ Hosp, Dept Pediat, Oslo, Norway. (author)
  • Vaitkeviciene, GodaVilnius Univ Hosp Santaros Klinikos, Childrens Hosp, Ctr Pediat Oncol & Hematol, Vilnius, Lithuania.;Vilnius Univ, Vilnius, Lithuania. (author)
  • Taskinen, MerviHelsinki Univ Hosp, Div Pediat Hematol Oncol & Stem Cell Transplantat, Helsinki, Finland. (author)
  • Schmiegelow, KjeldUniv Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Inst Clin Med, Copenhagen, Denmark. (author)
  • Univ Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.Univ Copenhagen, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark. (creator_code:org_t)

Related titles

  • In:Leukemia: Springer Nature34:2, s. 336-3460887-69241476-5551

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