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FältnamnIndikatorerMetadata
00004998naa a2200517 4500
001oai:DiVA.org:uu-409713
003SwePub
008200504s2020 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:231534171
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4097132 URI
0247 a https://doi.org/10.1038/s41375-019-0570-12 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:2315341712 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Thastrup, Mariau Univ Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.4 aut
2451 0a Flow cytometric detection of leukemic blasts in cerebrospinal fluid predicts risk of relapse in childhood acute lymphoblastic leukemia :b a Nordic Society of Pediatric Hematology and Oncology study
264 c 2019-09-18
264 1b Springer Nature,c 2020
338 a print2 rdacarrier
500 a Correction in: Leukemia (epub 2020). DOI: https://doi.org/10.1038/s41375-020-0821-1
520 a Central nervous system (CNS) involvement by cytospin is associated with increased risk of relapse in childhood acute lymphoblastic leukemia. We investigated if flow cytometric analysis of cerebrospinal fluid (CSF) at diagnosis improves the prediction of relapse. This prospective cohort study included patients (1.0-17.9 years) treated according to the Nordic Society of Pediatric Hematology and Oncology ALL2008 protocol. CSF flow cytometry samples were obtained at 17 centers, preserved with Transfix (R), and analyzed at a central laboratory. One-hundred and seventy-one (25.4%) of 673 patients were positive by flow cytometry (CNSflow+). The 4-year cumulative incidence of relapse was higher for patients with cytospin positivity (CNScyto+) (17.1% vs. 7.5%), CNSflow+ (16.5% vs. 5.6%), and cytospin and/or flow positivity (CNScomb+) (16.7% vs. 5.1%). In Cox regression analysis stratified by immunophenotype and minimal residual disease day 29 and adjusted by sex, predictors of relapse were age (hazard ratio [HR] 1.1, 95% CI 1.1-1.2, P < 0.001), white blood cell count at diagnosis (HR 1.4, 95% CI 1.1-1.6, P < 0.001), and CNScomb+ (HR 2.2, 95% CI 1.0-4.7, P = 0.042). Flow cytometric analysis of CSF improves detection of CNS leukemia, distinguishes patients with high and low risk of relapse, and may improve future risk stratification and CNS-directed therapy.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Marquart, Hanne Vibekeu Univ Copenhagen, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark.4 aut
7001 a Levinsen, Metteu Univ Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.4 aut
7001 a Grell, Kathrineu Univ Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.;Univ Copenhagen, Dept Publ Hlth, Sect Biostat, Copenhagen, Denmark.4 aut
7001 a Abrahamsson, Jonasu Sahlgrens Univ Hosp, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden.4 aut
7001 a Albertsen, Birgitte Klugu Aarhus Univ Hosp, Children & Adolescent Hlth, Aarhus, Denmark.4 aut
7001 a Frandsen, Thomas Lethu Univ Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.4 aut
7001 a Harila-Saari, Arja H.u Uppsala universitet,Barnneurologi/Barnonkologi4 aut0 (Swepub:uu)arjha456
7001 a Lähteenmäki, Päivi Mariau Karolinska Institutet4 aut
7001 a Niinimäki, Riittau Univ Oulu, Oulu Univ Hosp, Dept Pediat, Oulu, Finland.;Univ Oulu, PEDEGO Res Unit, Oulu, Finland.4 aut
7001 a Pronk, Cornelis Janu Skane Univ Hosp, Dept Pediat, Lund, Sweden.4 aut
7001 a Ulvmoen, Ainau Oslo Univ Hosp, Dept Pediat, Oslo, Norway.4 aut
7001 a Vaitkeviciene, Godau Vilnius Univ Hosp Santaros Klinikos, Childrens Hosp, Ctr Pediat Oncol & Hematol, Vilnius, Lithuania.;Vilnius Univ, Vilnius, Lithuania.4 aut
7001 a Taskinen, Merviu Helsinki Univ Hosp, Div Pediat Hematol Oncol & Stem Cell Transplantat, Helsinki, Finland.4 aut
7001 a Schmiegelow, Kjeldu Univ Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Inst Clin Med, Copenhagen, Denmark.4 aut
7102 a Univ Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.b Univ Copenhagen, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark.4 org
7730 t Leukemiad : Springer Natureg 34:2, s. 336-346q 34:2<336-346x 0887-6924x 1476-5551
8564 u https://www.nature.com/articles/s41375-020-0821-1.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-409713
8564 8u https://doi.org/10.1038/s41375-019-0570-1
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:231534171

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