External validation of postoperative pancreatic fistula prediction scores in pancreatoduodenectomy : a systematic review and meta-analysis

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Fältnamn	Indikatorer	Metadata
000		04891naa a2200613 4500
001		oai:lup.lub.lu.se:24423fc4-d8b6-4ab3-926d-34b9c85624a6
003		SwePub
008		211213s2022 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/24423fc4-d8b6-4ab3-926d-34b9c85624a62 URI
024	7	a https://doi.org/10.1016/j.hpb.2021.10.0062 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a for2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Pande, Rupalyu New Queen Elizabeth Hospital4 aut
245	1 0	a External validation of postoperative pancreatic fistula prediction scores in pancreatoduodenectomy : a systematic review and meta-analysis
264	1	b Elsevier BV,c 2022
520		a Background: Multiple risk scores claim to predict the probability of postoperative pancreatic fistula (POPF) after pancreatoduodenectomy. It is unclear which scores have undergone external validation and are the most accurate. The aim of this study was to identify risk scores for POPF, and assess the clinical validity of these scores. Methods: Areas under receiving operator characteristic curve (AUROCs) were extracted from studies that performed external validation of POPF risk scores. These were pooled for each risk score, using intercept-only random-effects meta-regression models. Results: Systematic review identified 34 risk scores, of which six had been subjected to external validation, and so included in the meta-analysis, (Tokyo (N=2 validation studies), Birmingham (N=5), FRS (N=19), a-FRS (N=12), m-FRS (N=3) and ua-FRS (N=3) scores). Overall predictive accuracies were similar for all six scores, with pooled AUROCs of 0.61, 0.70, 0.71, 0.70, 0.70 and 0.72, respectively. Considerably heterogeneity was observed, with I2 statistics ranging from 52.1-88.6%. Conclusion: Most risk scores lack external validation; where this was performed, risk scores were found to have limited predictive accuracy. Consensus is needed for which score to use in clinical practice. Due to the limited predictive accuracy, future studies to derive a more accurate risk score are warranted.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
700	1	a Halle-Smith, James M.u New Queen Elizabeth Hospital4 aut
700	1	a Phelan, Liamu New Queen Elizabeth Hospital4 aut
700	1	a Thorne, Thomasu New Queen Elizabeth Hospital4 aut
700	1	a Panikkar, M.u New Queen Elizabeth Hospital4 aut
700	1	a Hodson, Jamesu New Queen Elizabeth Hospital4 aut
700	1	a Roberts, Keith J.u University of Birmingham,New Queen Elizabeth Hospital4 aut
700	1	a Arshad, Aliu University Hospital Southampton4 aut
700	1	a Connor, Saxonu Christchurch Hospital New Zealand4 aut
700	1	a Conlon, Kevin CPu Trinity College Dublin4 aut
700	1	a Dickson, Euan J.u Glasgow Royal Infirmary4 aut
700	1	a Giovinazzo, Francescou Policlinico Universitario Agostino Gemelli4 aut
700	1	a Harrison, Ewenu University of Edinburgh4 aut
700	1	a de Liguori Carino, Nicolau Manchester University NHS Foundation Trust4 aut
700	1	a Hore, Toddu Christchurch Hospital New Zealand4 aut
700	1	a Knight, Stephen R.u University of Edinburgh4 aut
700	1	a Loveday, Benjaminu Royal Melbourne Hospital4 aut
700	1	a Magill, Laurau University of Birmingham4 aut
700	1	a Mirza, Dariusu New Queen Elizabeth Hospital4 aut
700	1	a Pandanaboyana, Sanjayu Freeman Hospital4 aut
700	1	a Perry, Rita J.u University of Birmingham4 aut
700	1	a Pinkney, Thomasu University of Birmingham4 aut
700	1	a Siriwardena, Ajith K.u Manchester University NHS Foundation Trust4 aut
700	1	a Satoi, Soheiu University of Colorado,Kansai Medical University4 aut
700	1	a Skipworth, James4 aut
700	1	a Stättner, Stefan4 aut
700	1	a Sutcliffe, Robert P.u New Queen Elizabeth Hospital4 aut
700	1	a Tingstedt, Bobbyu Lund University,Lunds universitet,Lever-, pankreas- och gallvägskirurgi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Hepato-Pancreato-Biliary Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments4 aut0 (Swepub:lu)kir-bti
710	2	a New Queen Elizabeth Hospitalb University of Birmingham4 org
710	2	a PARANOIA Study Group
773	0	t HPBd : Elsevier BVg 24:3, s. 287-298q 24:3<287-298x 1365-182X
856	4	u http://dx.doi.org/10.1016/j.hpb.2021.10.006y FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/24423fc4-d8b6-4ab3-926d-34b9c85624a6
856	4 8	u https://doi.org/10.1016/j.hpb.2021.10.006

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