WFRF:(Tommerup Henrik)
Sökning: WFRF:(Tommerup Henrik) > Single-molecule den...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02872naa a2200421 4500 | |
| 001 | oai:lup.lub.lu.se:8234947e-c081-4209-854f-abccf8287343 | |
| 003 | SwePub | |
| 008 | 160401s2010 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/16726042 URI |
| 024 | 7 | a https://doi.org/10.1073/pnas.10070811072 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Reisner, Walter4 aut |
| 245 | 1 0 | a Single-molecule denaturation mapping of DNA in nanofluidic channels |
| 264 | c 2010-07-07 | |
| 264 | 1 | b Proceedings of the National Academy of Sciences,c 2010 |
| 520 | a Here we explore the potential power of denaturation mapping as a single-molecule technique. By partially denaturing YOYO (R)-1-labeled DNA in nanofluidic channels with a combination of formamide and local heating, we obtain a sequence-dependent "barcode" corresponding to a series of local dips and peaks in the intensity trace along the extended molecule. We demonstrate that this structure arises from the physics of local denaturation: statistical mechanical calculations of sequence-dependent melting probability can predict the barcode to be observed experimentally for a given sequence. Consequently, the technique is sensitive to sequence variation without requiring enzymatic labeling or a restriction step. This technique may serve as the basis for a new mapping technology ideally suited for investigating the long-range structure of entire genomes extracted from single cells. | |
| 650 | 7 | a NATURVETENSKAPx Fysikx Den kondenserade materiens fysik0 (SwePub)103042 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Physical Sciencesx Condensed Matter Physics0 (SwePub)103042 hsv//eng |
| 653 | a DNA optical mapping | |
| 653 | a DNA barcoding | |
| 653 | a DNA denaturation | |
| 653 | a nanochannel | |
| 700 | 1 | a Larsen, Niels B.4 aut |
| 700 | 1 | a Silahtaroglu, Asli4 aut |
| 700 | 1 | a Kristensen, Anders4 aut |
| 700 | 1 | a Tommerup, Niels4 aut |
| 700 | 1 | a Tegenfeldt, Jonasu Lund University,Lunds universitet,Fasta tillståndets fysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Solid State Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)ftf-jte |
| 700 | 1 | a Flyvbjerg, Henrik4 aut |
| 710 | 2 | a Fasta tillståndets fysikb Fysiska institutionen4 org |
| 773 | 0 | t Proceedings of the National Academy of Sciencesd : Proceedings of the National Academy of Sciencesg 107:30, s. 13294-13299q 107:30<13294-13299x 1091-6490x 0027-8424 |
| 856 | 4 | u http://dx.doi.org/10.1073/pnas.1007081107x freey FULLTEXT |
| 856 | 4 | u https://www.pnas.org/content/pnas/107/30/13294.full.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1672604 |
| 856 | 4 8 | u https://doi.org/10.1073/pnas.1007081107 |
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