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Prevalence and prog...
Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study.
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- Visser, Pieter Jelle (författare)
- Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg, University of Maastricht, Netherlands; Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, Netherlands
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- Verhey, Frans (författare)
- Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg, University of Maastricht, Netherlands
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- Knol, Dirk L (författare)
- Department of Clinical Epidemiology and Statistics, VU University Medical Center, Amsterdam, Netherlands
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- Scheltens, Philip (författare)
- Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, Netherlands
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- Wahlund, Lars-Olof (författare)
- Karolinska Institutet
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- Freund-Levi, Yvonne, 1956- (författare)
- Department of NVS, Section of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
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- Tsolaki, Magda (författare)
- Aristotle University of Thessaloniki, Memory and Dementia Center, 3rd Department of Neurology, G Papanicolaou General Hospital, Thessaloniki, Greece
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- Minthon, Lennart (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
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- Wallin, Åsa (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
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- Hampel, Harald (författare)
- Alzheimer Memorial Center, Department of Psychiatry, Ludwig-Maximilian University, Munich, Germany; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience (TCIN), Laboratory of Neuroimaging and Biomarker Research, Trinity College, University of Dublin, The Adelaide, Dublin, Ireland; Meath Hospital incorporating the National Children's Hospital (AMiNCH), Dublin, Ireland
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- Bürger, Katharina (författare)
- Alzheimer Memorial Center, Department of Psychiatry, Ludwig-Maximilian University, Munich, Germany
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- Pirttila, Tuula (författare)
- Department of Neurology, University and University Hospital of Kuopio, Kuopio, Finland
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- Soininen, Hilkka (författare)
- Department of Neurology, University and University Hospital of Kuopio, Kuopio, Finland
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- Rikkert, Marcel Olde (författare)
- Department of Geriatrics, Alzheimer Center, Nijmegen Centre for Evidence Based Practice, Radboud University Medical Center, Nijmegen, Netherlands
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- Verbeek, Marcel M (författare)
- Department of Neurology, Donders Center for Brain, Cognition and Behaviour, Alzheimer Center, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands
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- Spiru, Luiza (författare)
- “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
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- Blennow, Kaj, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Clinical Neurochemistry Laboratory, Göteborg University, Sahlgrenska University Hospital, Mölndal, Sweden
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(creator_code:org_t)
- The Lancet Publishing Group, 2009
- 2009
- Engelska.
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Ingår i: Lancet neurology. - : The Lancet Publishing Group. - 1474-4422 .- 1474-4465. ; 8:7, s. 619-27
- Relaterad länk:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Alzheimer's disease (AD) pathology is common in patients with amnestic mild cognitive impairment (aMCI) without dementia, but the prevalence of AD pathology in patients with subjective cognitive impairment (SCI) and non-amnestic mild cognitive impairment (naMCI) is unknown. AD is characterised by decreased CSF concentrations of Abeta(42) and increased concentrations of tau. We investigated the prevalence of a CSF AD profile in patients with SCI, naMCI, or aMCI and the association of this profile with cognitive outcome in each group. METHODS: Patients with SCI, naMCI, aMCI, and neurologically healthy controls were recruited from 20 memory clinics across Europe, between January, 2003, and June, 2005, into this prospective cohort study. A CSF AD profile was defined as an abnormal ratio of Abeta(42):tau. Patients were assessed annually up to 3 years. Outcome measures were changes in memory, overall cognition, mini-mental state examination (MMSE) score, daily function, and progression to AD-type dementia. FINDINGS: The CSF AD profile was more common in patients with SCI (31 of 60 [52%]), naMCI (25 of 37 [68%]), and aMCI (56 of 71 [79%]) than in healthy controls (28 of 89 [31%]). The profile was associated with cognitive decline in patients with naMCI (memory, MMSE, and daily function) and in patients with aMCI (MMSE and daily function). In patients with aMCI, a CSF AD profile was predictive of AD-type dementia (OR 26.8, 95% CI 1.6-456.4). INTERPRETATION: AD is a common cause of SCI, naMCI, and aMCI and is associated with cognitive decline in patients with naMCI or aMCI. Patients with SCI might be in the early stages of AD, and cognitive decline might become apparent only after longer follow-up. FUNDING: European Commission; Ana Aslan International Foundation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Aged
- Alzheimer Disease
- cerebrospinal fluid
- diagnosis
- physiopathology
- Amyloid beta-Protein
- analysis
- cerebrospinal fluid
- Biological Markers
- analysis
- cerebrospinal fluid
- Cognition Disorders
- cerebrospinal fluid
- diagnosis
- physiopathology
- Cohort Studies
- Disability Evaluation
- Disease Progression
- Female
- Humans
- Male
- Middle Aged
- Neuropsychological Tests
- Peptide Fragments
- analysis
- cerebrospinal fluid
- Predictive Value of Tests
- Prevalence
- Prognosis
- Prospective Studies
- Sensitivity and Specificity
- Severity of Illness Index
- tau Proteins
- analysis
- cerebrospinal fluid
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
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Visser, Pieter J ...
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Verhey, Frans
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Knol, Dirk L
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Scheltens, Phili ...
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Wahlund, Lars-Ol ...
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Freund-Levi, Yvo ...
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Tsolaki, Magda
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Minthon, Lennart
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Wallin, Åsa
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Hampel, Harald
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Bürger, Katharin ...
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Pirttila, Tuula
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Soininen, Hilkka
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Rikkert, Marcel ...
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Verbeek, Marcel ...
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Spiru, Luiza
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Blennow, Kaj, 19 ...
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Lancet neurology
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Göteborgs universitet
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