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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006623naa a2200625 4500
001oai:gup.ub.gu.se/320536
003SwePub
008240528s2022 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:cb74396a-85f1-4849-b150-dab3224726f5
009oai:DiVA.org:liu-190203
0247 a https://gup.ub.gu.se/publication/3205362 URI
0247 a https://doi.org/10.1186/s12879-022-07830-42 DOI
0247 a https://lup.lub.lu.se/record/cb74396a-85f1-4849-b150-dab3224726f52 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1902032 URI
040 a (SwePub)gud (SwePub)lud (SwePub)liu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Tell, Davidu Linköpings universitet,Linköping University,Institutionen för hälsa, medicin och vård,Medicinska fakulteten,Futurum, Reg Jonkoping Cty, Sweden4 aut0 (Swepub:liu)n/a
2451 0a Clinical course of pharyngotonsillitis with group A streptococcus treated with different penicillin V strategies, divided in groups of Centor Score 3 and 4: a prospective study in primary care
264 c 2022-11-11
264 1b Springer Science and Business Media LLC,c 2022
500 a Funding Agencies|Public Health Agency of Sweden; Region Jonkoping County
520 a Background Sore throat is a common reason for prescribing antibiotics in primary care, and 10 days of treatment is recommended for patients with pharyngotonsillitis with group A streptococcus (GAS). Our group recently showed that penicillin V (PcV) four times daily for 5 days was non-inferior in clinical outcome to PcV three times daily for 10 days. This study compares duration, intensity of symptoms, and side effects in patients with a Centor Score (CS) of 3 or 4 respectively, after treatment with PcV for 5 or 10 days and evaluates whether all patients with pharyngotonsillitis with a CS of 3 or 4 should be treated for 5 days or if severity of symptoms or CS suggest a longer treatment period. Method Data on symptoms and recovery from patient diaries from 433 patients included in a RCT comparing PcV 800 mg x 4 for 5 days or PcV 1 g x 3 for 10 days was used. Patients six years and older with CS-3 or CS-4 and positive rapid antigen detection test for GAS-infection were grouped based on CS and randomized treatment. Comparisons for categorical variables were made with Pearson's chi-squared test or Fisher's exact test. Continuous variables were compared with the Mann-Whitney U test. Results Patients with CS-3 as well as patients with CS-4 who received PcV 800 mg x 4 for 5 days self-reported that they recovered earlier compared to patients with CS-3 or CS-4 who received treatment with PcV 1 g x 3 for 10 days. In addition, the throat pain as single symptom was relieved 1 day earlier in patients with CS-4 and 5 days of treatment compared to patients with CS-4 and 10 days of treatment. No differences in side effects between the groups were found. Conclusion Intense treatment with PcV four times a day for 5 days seems clinically beneficial and strengthens the suggestion that the 4-dose regimen with 800 mg PcV for 5 days may be the future treatment strategy for GAS positive pharyngotonsillitis irrespectively of CS-3 or CS-4. Trail registration ClinicalTrials.gov ID: NCT02712307 (3 April 2016).
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Allmänmedicin0 (SwePub)302242 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex General Practice0 (SwePub)302242 hsv//eng
653 a Pharyngotonsillitis
653 a Centor Score 3 and 4
653 a Phenoxymethylpenicillin
653 a Primary care
653 a pyogenes-emm-types
653 a acute sore throat
653 a noninvasive infections
653 a children
653 a epidemiology
653 a trial
653 a Infectious Diseases
653 a Pharyngotonsillitis; Centor Score 3 and 4; Phenoxymethylpenicillin; Primary care
7001 a Tyrstrup, Miau Lund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups,Lund Univ, Sweden4 aut0 (Swepub:lu)med-mty
7001 a Edlund, C.u Public Health Agency of Sweden4 aut
7001 a Rystedt, Karinu University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,CARe - Centrum för antibiotikaresistensforskning,Institute of Medicine, School of Public Health and Community Medicine,Centre for antibiotic resistance research, CARe,Sahlgrenska Academy,Univ Gothenburg, Sweden; Primary Hlth Care, Sweden; Univ Gothenburg, Sweden4 aut
7001 a Stahlgren, G. S.u Public Health Agency of Sweden4 aut
7001 a Sundvall, Pär-Danielu University of Gothenburg,Gothenburg University,Göteborgs universitet,CARe - Centrum för antibiotikaresistensforskning,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Centre for antibiotic resistance research, CARe,Institute of Medicine, School of Public Health and Community Medicine,Sahlgrenska Academy,Univ Gothenburg, Sweden; Primary Hlth Care, Sweden; Univ Gothenburg, Sweden4 aut0 (Swepub:gu)xsupar
7001 a Hedin, Katarinau Linköpings universitet,Linköping University,Lund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups,Region Jönköping County,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Futurum, Reg Jonkoping Cty, Sweden; Lund Univ, Sweden4 aut0 (Swepub:liu)kathe53
7102 a Linköping Universityb Institutionen för hälsa, medicin och vård4 org
7730 t BMC Infectious Diseasesd : Springer Science and Business Media LLCg 22:1q 22:1x 1471-2334
8564 u http://dx.doi.org/10.1186/s12879-022-07830-4x freey FULLTEXT
8564 u https://liu.diva-portal.org/smash/get/diva2:1714433/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://gup.ub.gu.se/publication/320536
8564 8u https://doi.org/10.1186/s12879-022-07830-4
8564 8u https://lup.lub.lu.se/record/cb74396a-85f1-4849-b150-dab3224726f5
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-190203

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