WFRF:(Uppugunduri Srinivas)
Sökning: WFRF:(Uppugunduri Srinivas) > Pharmacogenetic asp...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04088naa a2200349 4500 | |
| 001 | oai:DiVA.org:liu-106838 | |
| 003 | SwePub | |
| 008 | 140523s2014 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1068382 URI |
| 024 | 7 | a https://doi.org/10.1016/j.forsciint.2014.03.0032 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bastami, Salumehu Linköpings universitet,Avdelningen för läkemedelsforskning,Hälsouniversitetet4 aut0 (Swepub:liu)salba62 |
| 245 | 1 0 | a Pharmacogenetic aspects of tramadol pharmacokinetics and pharmacodynamics after a single oral dose |
| 264 | 1 | b Elsevier,c 2014 |
| 338 | a print2 rdacarrier | |
| 520 | a The major purpose of this study was to elucidate if genotyping can facilitate interpretations of tramadol (TRA) in forensic case work, with special regard to the estimation of the time of drug intake and drug related symptoms (DRS). The association between genetic polymorphisms in CYP2D6, OPRM1 and ABCB1 and pharmacokinetic and pharmacodynamic properties of TRA was studied. Nineteen healthy volunteers were randomized into two groups receiving a single dose of either 50 or 100 mg of orally administrated TRA. Blood samples were collected prior to dosing and up to 72 h after drug intake. The subjects were asked to report DRS during the experimental day. We found a positive correlation between the metabolic ratio of O-desmethyltramadol (ODT) to TRA and the time after drug intake for both CYP2D6 intermediate metabolizers and extensive metabolizers. For the only poor metabolizer with detectable ODT levels the metabolic ratio was almost constant. Significant associations were found between the area under the concentration-time curve (AUC) and three of the investigated ABCB1 single nucleotide polymorphisms for TRA, but not for ODT and only in the 50 mg dosage group. There was great interindividual variation in DRS, some subjects exhibited no symptoms at all whereas one subject both fainted and vomited after a single therapeutic dose. However, no associations could be found between DRS and investigated polymorphisms. We conclude that the metabolic ratio of ODT/TRA may be used for estimation of the time of drug intake, but only when the CYP2D6 genotype is known and taken into consideration. The influence of genetic polymorphisms in ABCB1 and OPRM1 requires further study. | |
| 653 | a Tramadol; Pharmacokinetics; Pharmacodynamics; CYP2D6; ABCB1; OPRM1 | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Haage, Pernillau Linköpings universitet,Avdelningen för läkemedelsforskning,Hälsouniversitetet,National Board of Forensic Medicine, Department of Forensic Genetics and Forensic Toxicology, Linköping, Sweden4 aut0 (Swepub:liu)perha12 |
| 700 | 1 | a Kronstrand, Robertu Linköpings universitet,Avdelningen för läkemedelsforskning,Hälsouniversitetet,National Board of Forensic Medicine, Department of Forensic Genetics and Forensic Toxicology, Linköping, Sweden4 aut0 (Swepub:liu)robkr41 |
| 700 | 1 | a Kugelberg, Fredriku Linköpings universitet,Avdelningen för läkemedelsforskning,Hälsouniversitetet,National Board of Forensic Medicine, Department of Forensic Genetics and Forensic Toxicology, Linköping, Sweden4 aut0 (Swepub:liu)freku57 |
| 700 | 1 | a Zackrisson, Anna-Lenau National Board of Forensic Medicine, Department of Forensic Genetics and Forensic Toxicology, Linköping, Sweden4 aut0 (Swepub:liu)annza49 |
| 700 | 1 | a Uppugunduri, Srinivasu Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet,Klinisk kemi4 aut0 (Swepub:liu)sriup42 |
| 710 | 2 | a Linköpings universitetb Avdelningen för läkemedelsforskning4 org |
| 773 | 0 | t Forensic Science Internationald : Elsevierg 238, s. 125-132q 238<125-132x 0379-0738x 1872-6283 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-106838 |
| 856 | 4 8 | u https://doi.org/10.1016/j.forsciint.2014.03.003 |
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