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Brief Report: Ritux...
Brief Report: Rituximab for the Treatment of Adult-Onset IgA Vasculitis (Henoch-Schonlein)
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- Maritati, Federica (författare)
- Parma University Hospital, Italy
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- Fenoglio, Roberta (författare)
- G Bosco Hospital, Italy; University of Turin, Italy
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- Pillebout, Evangeline (författare)
- St Louis Hospital, France,Saint-Louis Hospital, Paris
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- Emmi, Giacomo (författare)
- University of Florence, Italy
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- Urban, Maria L. (författare)
- Parma University Hospital, Italy
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- Rocco, Rossana (författare)
- Parma University Hospital, Italy
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- Nicastro, Maria (författare)
- Parma University Hospital, Italy
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- Incerti, Monia (författare)
- Parma University Hospital, Italy
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- Goldoni, Matteo (författare)
- University of Parma, Italy
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- Trivioli, Giorgio (författare)
- Parma University Hospital, Italy
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- Silvestri, Elena (författare)
- University of Florence, Italy
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- Mohammad, Aladdin J. (författare)
- Lund University,Lunds universitet,Lund Vasculitis Epidemiology Research Group,Forskargrupper vid Lunds universitet,Lund University Research Groups,Lund University, Sweden; University of Cambridge, England
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- Jayne, David (författare)
- University of Cambridge, England
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- Eriksson, Per (författare)
- Linköping University,Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
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- Segelmark, Mårten (författare)
- Linköping University,Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US
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- Novikov, Pavel (författare)
- Sechenov First Moscow State Medical University, Russia
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- Harris, Helen (författare)
- Whytemans Brae Hospital, Scotland
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- Roccatello, Dario (författare)
- G Bosco Hospital, Italy; University of Turin, Italy
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- Vaglio, Augusto (författare)
- Parma University Hospital, Italy
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(creator_code:org_t)
- 2017-12
- 2018
- Engelska.
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Ingår i: Arthritis & Rheumatology. - : WILEY. - 2326-5191 .- 2326-5205. ; 70:1, s. 109-114
- Relaterad länk:
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https://iris.unito.i...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
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- ObjectiveAdult-onset IgA vasculitis (Henoch-Schonlein) (IgAV) is a rare systemic vasculitis characterized by IgA1-dominant deposits. The treatment of adult-onset IgAV is controversial and is based on the combination of glucocorticoids and immunosuppressive agents, but many patients have refractory or relapsing disease despite treatment. Rituximab (RTX) is a B cell-depleting antibody of proven efficacy in antineutrophil cytoplasmic antibody-associated vasculitis. We undertook this study to test the efficacy and safety of RTX in a multicenter cohort of patients with adult-onset IgAV. MethodsIn this multicenter observational study, we included patients with adult-onset IgAV who had received RTX either for refractory/relapsing disease or because they had contraindications to conventional glucocorticoid/immunosuppressive therapy. We analyzed the rates of remission (defined on the basis of the Birmingham Vasculitis Activity Score [BVAS]) and relapse as well as the variations over time in estimated glomerular filtration rate (GFR), proteinuria, C-reactive protein (CRP) level, BVAS, and prednisone dose. ResultsTwenty-two patients were included; their median duration of follow-up was 24 months (interquartile range 18-48 months). Sixteen patients received RTX as add-on therapy and 6 as monotherapy. Twenty patients (90.9%) achieved remission, and 7 of those 20 patients (35%) had subsequent relapse of disease. There were significant reductions in 24-hour proteinuria (P amp;lt; 0.0001), CRP level (P = 0.0005), BVAS (P amp;lt; 0.0001), and prednisone dose (P amp;lt; 0.0001) from RTX initiation through the last follow-up visit; estimated GFR remained stable. RTX was generally well tolerated. One patient died after 60 months of follow-up. ConclusionOur data suggest that RTX is an effective and safe therapeutic option for adult-onset IgAV.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Maritati, Federi ...
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Fenoglio, Robert ...
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Pillebout, Evang ...
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Emmi, Giacomo
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Urban, Maria L.
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Rocco, Rossana
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Nicastro, Maria
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Incerti, Monia
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Goldoni, Matteo
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Trivioli, Giorgi ...
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Silvestri, Elena
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Mohammad, Aladdi ...
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Jayne, David
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Eriksson, Per
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Segelmark, Mårte ...
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Novikov, Pavel
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Harris, Helen
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Roccatello, Dari ...
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Vaglio, Augusto
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