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The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes

Thorell, Kaisa, 1983 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
Muñoz-Ramírez, Zilia Y. (author)
Wang, Difei (author)
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Sandoval-Motta, Santiago (author)
Boscolo Agostini, Rajiv (author)
Ghirotto, Silvia (author)
Torres, Roberto C. (author)
Romero-Gallo, Judith (author)
Krishna, Uma (author)
Peek, Richard M. (author)
Piazuelo, M. Blanca (author)
Raaf, Naïma (author)
Bentolila, Federico (author)
Aftab, Hafeza (author)
Akada, Junko (author)
Matsumoto, Takashi (author)
Haesebrouck, Freddy (author)
Colanzi, Rony P. (author)
Bartelli, Thais F. (author)
Nunes, Diana Noronha (author)
Pelosof, Adriane (author)
Sztokfisz, Claudia Zitron (author)
Dias-Neto, Emmanuel (author)
Assumpção, Paulo Pimentel (author)
Tishkov, Ivan (author)
Mabeku, Laure Brigitte Kouitcheu (author)
Goodman, Karen J. (author)
Geary, Janis (author)
Cromarty, Taylor J. (author)
Price, Nancy L. (author)
Quilty, Douglas (author)
Corvalan, Alejandro H. (author)
Serrano, Carolina A. (author)
Gonzalez, Robinson (author)
Riquelme, Arnoldo (author)
García-Cancino, Apolinaria (author)
Parra-Sepúlveda, Cristian (author)
Bernal, Giuliano (author)
Castillo, Francisco (author)
Goldstein, Alisa M. (author)
Hu, Nan (author)
Taylor, Philip R. (author)
Bravo, Maria Mercedes (author)
Pazos, Alvaro (author)
Bravo, Luis E. (author)
Wilson, Keith T. (author)
Fox, James G. (author)
Ramírez-Mayorga, Vanessa (author)
Molina-Castro, Silvia (author)
Durán-Bermúdez, Sundry (author)
Campos-Núñez, Christian (author)
Chaves-Cervantes, Manuel (author)
Tshibangu-Kabamba, Evariste (author)
Tumba, Ghislain Disashi (author)
Tshimpi-Wola, Antoine (author)
de Jesus Ngoma-Kisoko, Patrick (author)
Ngoyi, Dieudonné Mumba (author)
Cruz, Modesto (author)
Hosking, Celso (author)
Abreu, José Jiménez (author)
Varon, Christine (author)
Benejat, Lucie (author)
Secka, Ousman (author)
Link, Alexander (author)
Malfertheiner, Peter (author)
Adinortey, Michael Buenor (author)
Bockarie, Ansumana Sandy (author)
Adinortey, Cynthia Ayefoumi (author)
Ofori, Eric Gyamerah (author)
Sgouras, Dionyssios N. (author)
Martinez-Gonzalez, Beatriz (author)
Michopoulos, Spyridon (author)
Georgopoulos, Sotirios (author)
Hernandez, Elisa (author)
Tacatic, Braulio Volga (author)
Aguilar, Mynor (author)
Dominguez, Ricardo L. (author)
Morgan, Douglas R. (author)
Harðardóttir, Hjördís (author)
Gunnarsdóttir, Anna Ingibjörg (author)
Guðjónsson, Hallgrímur (author)
Jónasson, Jón Gunnlaugur (author)
Björnsson, Einar S. (author)
Ballal, Mamatha (author)
Shetty, Vignesh (author)
Miftahussurur, Muhammad (author)
Sugihartono, Titong (author)
Alfaray, Ricky Indra (author)
Waskito, Langgeng Agung (author)
Fauzia, Kartika Afrida (author)
Syam, Ari Fahrial (author)
Maulahela, Hasan (author)
Malekzadeh, Reza (author)
Sotoudeh, Masoud (author)
Peretz, Avi (author)
Azrad, Maya (author)
On, Avi (author)
De Re, Valli (author)
Zanussi, Stefania (author)
Cannizzaro, Renato (author)
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 (creator_code:org_t)
2023
2023
English.
In: Nature Communications. - 2041-1723. ; 14:1
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk. Here, we provide insights into H. pylori population structure as a part of the Helicobacter pylori Genome Project (HpGP), a multi-disciplinary initiative aimed at elucidating H. pylori pathogenesis and identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from 50 countries and generated high-quality genome sequences. We analysed core genome diversity and population structure of the HpGP dataset and 255 worldwide reference genomes to outline the ancestral contribution to Eurasian, African, and American populations. We found evidence of substantial contribution of population hpNorthAsia and subpopulation hspUral in Northern European H. pylori. The genomes of H. pylori isolated from northern and southern Indigenous Americans differed in that bacteria isolated in northern Indigenous communities were more similar to North Asian H. pylori while the southern had higher relatedness to hpEastAsia. Notably, we also found a highly clonal yet geographically dispersed North American subpopulation, which is negative for the cag pathogenicity island, and present in 7% of sequenced US genomes. We expect the HpGP dataset and the corresponding strains to become a major asset for H. pylori genomics.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

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By the author/editor
Thorell, Kaisa, ...
Muñoz-Ramírez, Z ...
Wang, Difei
Sandoval-Motta, ...
Boscolo Agostini ...
Ghirotto, Silvia
show more...
Torres, Roberto ...
Romero-Gallo, Ju ...
Krishna, Uma
Peek, Richard M.
Piazuelo, M. Bla ...
Raaf, Naïma
Bentolila, Feder ...
Aftab, Hafeza
Akada, Junko
Matsumoto, Takas ...
Haesebrouck, Fre ...
Colanzi, Rony P.
Bartelli, Thais ...
Nunes, Diana Nor ...
Pelosof, Adriane
Sztokfisz, Claud ...
Dias-Neto, Emman ...
Assumpção, Paulo ...
Tishkov, Ivan
Mabeku, Laure Br ...
Goodman, Karen J ...
Geary, Janis
Cromarty, Taylor ...
Price, Nancy L.
Quilty, Douglas
Corvalan, Alejan ...
Serrano, Carolin ...
Gonzalez, Robins ...
Riquelme, Arnold ...
García-Cancino, ...
Parra-Sepúlveda, ...
Bernal, Giuliano
Castillo, Franci ...
Goldstein, Alisa ...
Hu, Nan
Taylor, Philip R ...
Bravo, Maria Mer ...
Pazos, Alvaro
Bravo, Luis E.
Wilson, Keith T.
Fox, James G.
Ramírez-Mayorga, ...
Molina-Castro, S ...
Durán-Bermúdez, ...
Campos-Núñez, Ch ...
Chaves-Cervantes ...
Tshibangu-Kabamb ...
Tumba, Ghislain ...
Tshimpi-Wola, An ...
de Jesus Ngoma-K ...
Ngoyi, Dieudonné ...
Cruz, Modesto
Hosking, Celso
Abreu, José Jimé ...
Varon, Christine
Benejat, Lucie
Secka, Ousman
Link, Alexander
Malfertheiner, P ...
Adinortey, Micha ...
Bockarie, Ansuma ...
Adinortey, Cynth ...
Ofori, Eric Gyam ...
Sgouras, Dionyss ...
Martinez-Gonzale ...
Michopoulos, Spy ...
Georgopoulos, So ...
Hernandez, Elisa
Tacatic, Braulio ...
Aguilar, Mynor
Dominguez, Ricar ...
Morgan, Douglas ...
Harðardóttir, Hj ...
Gunnarsdóttir, A ...
Guðjónsson, Hall ...
Jónasson, Jón Gu ...
Björnsson, Einar ...
Ballal, Mamatha
Shetty, Vignesh
Miftahussurur, M ...
Sugihartono, Tit ...
Alfaray, Ricky I ...
Waskito, Langgen ...
Fauzia, Kartika ...
Syam, Ari Fahria ...
Maulahela, Hasan
Malekzadeh, Reza
Sotoudeh, Masoud
Peretz, Avi
Azrad, Maya
On, Avi
De Re, Valli
Zanussi, Stefani ...
Cannizzaro, Rena ...
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Microbiology in ...
Articles in the publication
Nature Communica ...
By the university
University of Gothenburg

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