Rapid changes in DNA methylation associated with the initiation of reproduction in a small songbird

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Fältnamn	Indikatorer	Metadata
000		04644naa a2200481 4500
001		oai:DiVA.org:uu-454304
003		SwePub
008		210928s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4543042 URI
024	7	a https://doi.org/10.1111/mec.158032 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Lindner, Melanieu Netherlands Inst Ecol NIOO KNAW, Dept Anim Ecol, Wageningen, Netherlands.;Univ Groningen, Groningen Inst Evolutionary Life Sci GELIFES, Chronobiol Unit, Groningen, Netherlands.4 aut
245	1 0	a Rapid changes in DNA methylation associated with the initiation of reproduction in a small songbird
264		c 2021-02-02
264	1	b John Wiley & Sons,c 2021
338		a electronic2 rdacarrier
520		a Species with a circannual life cycle need to match the timing of their life history events to the environment to maximize fitness. However, our understanding of how circannual traits such as timing of reproduction are regulated on a molecular level remains limited. Recent studies have implicated that epigenetic mechanisms can be an important part in the processes that regulate circannual traits. Here, we explore the role of DNA methylation in mediating reproductive timing in a seasonally breeding bird species, the great tit (Parus major), using genome-wide DNA methylation data from individual females that were blood sampled repeatedly throughout the breeding season. We demonstrate rapid and directional changes in DNA methylation within the promoter region of several genes, including a key transcription factor (NR5A1) known from earlier studies to be involved in the initiation of timing of reproduction. Interestingly, the observed changes in DNA methylation at NR5A1 identified here are in line with earlier gene expression studies of reproduction in chicken, indicating that the observed shifts in DNA methylation at this gene can have a regulatory role. Our findings provide an important step towards elucidating the genomic mechanism that mediates seasonal timing of a key life history traits and provide support for the idea that epigenetic mechanisms may play an important role in circannual traits.
650	7	a NATURVETENSKAPx Biologix Evolutionsbiologi0 (SwePub)106152 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Evolutionary Biology0 (SwePub)106152 hsv//eng
650	7	a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng
653		a avian reproductive timing
653		a DNA methylation
653		a ecological epigenetics
653		a life history traits
653		a Parus major
700	1	a Laine, Veronika N.u Netherlands Inst Ecol NIOO KNAW, Dept Anim Ecol, Wageningen, Netherlands.;Univ Helsinki, Finnish Museum Nat Hist, Helsinki, Finland.4 aut
700	1	a Verhagen, Ireneu Netherlands Inst Ecol NIOO KNAW, Dept Anim Ecol, Wageningen, Netherlands.4 aut
700	1	a Viitaniemi, Heidi M.u Univ Helsinki, Organismal & Evolutionary Biol Res Programme OEB, Helsinki, Finland.4 aut
700	1	a Visser, Marcel E.u Netherlands Inst Ecol NIOO KNAW, Dept Anim Ecol, Wageningen, Netherlands.;Univ Groningen, Groningen Inst Evolutionary Life Sci GELIFES, Chronobiol Unit, Groningen, Netherlands.4 aut
700	1	a van Oers, Keesu Netherlands Inst Ecol NIOO KNAW, Dept Anim Ecol, Wageningen, Netherlands.4 aut
700	1	a Husby, Arild,c Associate Senior Lectureru Uppsala universitet,Evolutionsbiologi,Univ Helsinki, Organismal & Evolutionary Biol Res Programme OEB, Helsinki, Finland.;NTNU, Ctr Biodivers Dynam, Trondheim, Norway.4 aut0 (Swepub:uu)arihu528
710	2	a Netherlands Inst Ecol NIOO KNAW, Dept Anim Ecol, Wageningen, Netherlands.;Univ Groningen, Groningen Inst Evolutionary Life Sci GELIFES, Chronobiol Unit, Groningen, Netherlands.b Netherlands Inst Ecol NIOO KNAW, Dept Anim Ecol, Wageningen, Netherlands.;Univ Helsinki, Finnish Museum Nat Hist, Helsinki, Finland.4 org
773	0	t Molecular Ecologyd : John Wiley & Sonsg 30:15, s. 3645-3659q 30:15<3645-3659x 0962-1083x 1365-294X
856	4	u https://doi.org/10.1111/mec.15803y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1597860/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/mec.15803
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-454304
856	4 8	u https://doi.org/10.1111/mec.15803

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Av författaren/redakt...: Lindner, Melanie; Laine, Veronika ...; Verhagen, Irene; Viitaniemi, Heid ...; Visser, Marcel E ...; van Oers, Kees; visa fler...; Husby, Arild, As ...; visa färre...

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