Auditory effects of developmental exposure to purity-controlled Polychlorinated Biphenyls (PCB52 and PCB180) in rats

Lilienthal, HellmuthCenter of Toxicology, IPA – Institute for Prevention and Occupational Medicine, German Social Accident Insurance, Ruhr University of Bochum, 44789 Bochum, Germany (författare)

Polychlorinated biphenyls (PCBs) are still present in the environment, with ongoing exposure in humans, including babies nursed by their mothers. Whereas toxicity of dioxin-like PCBs is well described, less systematic knowledge is available for non-dioxin-like PCBs (NDL-PCBs) which do not act via the Ah receptor. This study compared effects of developmental exposure to two ultrapure NDL-PCB congeners (PCB52 and PCB180) on auditory function in rats, using the brainstem auditory evoked potential (BAEP). Pregnant rats received repeated oral doses of PCB52 (total dose - 0, 30, 100, 300, 1000, or 3000 mg/kg body weight) or of PCB180 (total dose - 0, 10, 30, 100, 300, or 1000 mg/kg). BAEPs were recorded in adult male and female offspring after stimulation with clicks or pure tones in the frequency range from 0.5 kHz to 16 kHz. Significant elevation of BAEP thresholds were detected in the low-frequency range after developmental exposure to PCB52. Calculation of benchmark doses revealed lowest values in the frequency range of 0.5 - 2 kHz. Effects were more pronounced in male compared to female offspring. Latencies of waves II and IV were prolonged in exposed males, while only wave IV was affected in females. PCB180 increased thresholds only at few conditions and only in female offspring. These results confirm that developmental exposure to ultrapure NDL-PCBs affects auditory function, but different congeners exhibit differences in potencies.

Heikkinen, PäiviDepartment of Environmental Health, THL – National Institute for Health and Welfare, 70701 Kuopio, Finland (författare)
Andersson, Patrik LUmeå universitet,Kemiska institutionen(Swepub:umu)paan0001 (författare)
van der Ven, Leo T MLaboratory for Health Protection Research, RIVM - National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands (författare)
Viluksela, MattiDepartment of Environmental Health, THL – National Institute for Health and Welfare, 70701 Kuopio, Finland (författare)
Center of Toxicology, IPA – Institute for Prevention and Occupational Medicine, German Social Accident Insurance, Ruhr University of Bochum, 44789 Bochum, GermanyDepartment of Environmental Health, THL – National Institute for Health and Welfare, 70701 Kuopio, Finland (creator_code:org_t)

Ingår i:Toxicological Sciences: Oxford Journals122:1, s. 100-1111096-60801096-0929

Av författaren/redakt...: Lilienthal, Hell ...; Heikkinen, Päivi; Andersson, Patri ...; van der Ven, Leo ...; Viluksela, Matti

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