Sökning: WFRF:(WHITTEMORE A) > Ovarian cancer and ...
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000 | 09853naa a2202197 4500 | |
001 | oai:lup.lub.lu.se:c1a1fd7e-5d1f-43e4-bb38-7b42c5b60d15 | |
003 | SwePub | |
008 | 160401s2012 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:125207885 | |
024 | 7 | a https://lup.lub.lu.se/record/31468962 URI |
024 | 7 | a https://doi.org/10.1016/S1470-2045(12)70322-42 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1252078852 URI |
040 | a (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Beral, V.4 aut |
245 | 1 0 | a Ovarian cancer and smoking: individual participant meta-analysis including 28 114 women with ovarian cancer from 51 epidemiological studies |
264 | 1 | c 2012 |
300 | a 11 s. | |
520 | a Background Smoking has been linked to mucinous ovarian cancer, but its effects on other ovarian cancer subtypes and on overall ovarian cancer risk are unclear, and the findings from most studies with relevant data are unpublished. To assess these associations, we review the published and unpublished evidence. Methods Eligible epidemiological studies were identified by electronic searches, review articles, and discussions with colleagues. Individual participant data for 28 114 women with and 94 942 without ovarian cancer from 51 epidemiological studies were analysed centrally, yielding adjusted relative risks (RRs) of ovarian cancer in smokers compared with never smokers. Findings After exclusion of studies with hospital controls, in which smoking could have affected recruitment, overall ovarian cancer incidence was only slightly increased in current smokers compared with women who had never smoked (RR 1.06, 95% CI 1.01-1.11, p=0.01). Of 17 641 epithelial cancers with specified histology, 2314 (13%) were mucinous, 2360 (13%) endometrioid, 969 (5%) clear-cell, and 9086 (52%) serous. Smoking-related risks varied substantially across these subtypes (p(heterogeneity)<0.0001). For mucinous cancers, incidence was increased in current versus never smokers (1.79, 95% CI 1.60-2.00, p<0.0001), but the increase was mainly in borderline malignant rather than in fully malignant tumours (2.25, 95% CI 1.91-2.65 vs 1.49, 1.28-1.73; p(heterogeneity)=0.01; almost half the mucinous tumours were only borderline malignant). Both endometrioid (0.81, 95% CI 0.72-0.92, p=0.001) and clear-cell ovarian cancer risks (0.80, 95% CI 0.65-0.97, p=0.03) were reduced in current smokers, and there was no significant association for serous ovarian cancers (0.99, 95% CI 0.93-1.06, p=0.8). These associations did not vary significantly by 13 sociodemographic and personal characteristics of women including their body-mass index, parity, and use of alcohol, oral contraceptives, and menopausal hormone therapy. Interpretation The excess of mucinous ovarian cancers in smokers, which is mainly of tumours of borderline malignancy, is roughly counterbalanced by the deficit of endometrioid and clear-cell ovarian cancers. The substantial variation in smoking-related risks by tumour subtype is important for understanding ovarian carcinogenesis. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
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700 | 1 | a Sadetzki, S.4 aut |
700 | 1 | a Banks, E.4 aut |
700 | 1 | a Beral, V.4 aut |
700 | 1 | a Bull, D.4 aut |
700 | 1 | a Callaghan, K.4 aut |
700 | 1 | a Crossley, B.4 aut |
700 | 1 | a Gaitskell, K.4 aut |
700 | 1 | a Goodill, A.4 aut |
700 | 1 | a Green, J.4 aut |
700 | 1 | a Hermon, C.4 aut |
700 | 1 | a Key, T.4 aut |
700 | 1 | a Moser, K.4 aut |
700 | 1 | a Reeves, G.4 aut |
700 | 1 | a Sitas, F.4 aut |
700 | 1 | a Collins, R.4 aut |
700 | 1 | a Doll, R.4 aut |
700 | 1 | a Peto, R.4 aut |
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700 | 1 | a Marchbanks, P.4 aut |
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700 | 1 | a La Vecchia, C.4 aut |
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700 | 1 | a Adami, H. O.u Karolinska Institutet4 aut |
700 | 1 | a Magnusson, C.u Karolinska Institutet4 aut |
700 | 1 | a Riman, T.4 aut |
700 | 1 | a Weiderpass, E.u Karolinska Institutet4 aut |
700 | 1 | a Wolk, A.u Karolinska Institutet4 aut |
700 | 1 | a Schouten, L. J.4 aut |
700 | 1 | a van den Brandt, P. A.4 aut |
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700 | 1 | a Brinton, L. A.4 aut |
700 | 1 | a Freedman, D. M.4 aut |
700 | 1 | a Hartge, P.4 aut |
700 | 1 | a Hsing, A. W.4 aut |
700 | 1 | a Lacey, J. V.4 aut |
700 | 1 | a Hoover, R. N.4 aut |
700 | 1 | a Schairer, C.4 aut |
700 | 1 | a Urban, M.4 aut |
700 | 1 | a Graff-Iversen, S.4 aut |
700 | 1 | a Selmer, R.4 aut |
700 | 1 | a Bain, C. J.4 aut |
700 | 1 | a Green, A. C.4 aut |
700 | 1 | a Purdie, D. M.4 aut |
700 | 1 | a Siskind, V.4 aut |
700 | 1 | a Webb, P. M.4 aut |
700 | 1 | a Moysich, K.4 aut |
700 | 1 | a McCann, S. E.4 aut |
700 | 1 | a Hannaford, P.4 aut |
700 | 1 | a Kay, C.4 aut |
700 | 1 | a Binns, C. W.4 aut |
700 | 1 | a Lee, A. H.4 aut |
700 | 1 | a Zhang, M.4 aut |
700 | 1 | a Ness, R. B.4 aut |
700 | 1 | a Nasca, P.4 aut |
700 | 1 | a Coogan, P. F.4 aut |
700 | 1 | a Palmer, J. R.4 aut |
700 | 1 | a Rosenberg, L.4 aut |
700 | 1 | a Kelsey, J.4 aut |
700 | 1 | a Paffenbarger, R.4 aut |
700 | 1 | a Whittemore, A.4 aut |
700 | 1 | a Katsouyanni, K.4 aut |
700 | 1 | a Trichopoulou, A.4 aut |
700 | 1 | a Trichopoulos, D.4 aut |
700 | 1 | a Tzonou, A.4 aut |
700 | 1 | a Dabancens, A.4 aut |
700 | 1 | a Martinez, L.4 aut |
700 | 1 | a Molina, R.4 aut |
700 | 1 | a Salas, O.4 aut |
700 | 1 | a Goodman, M. T.4 aut |
700 | 1 | a Lurie, G.4 aut |
700 | 1 | a Carney, M. E.4 aut |
700 | 1 | a Wilkens, L. R.4 aut |
700 | 1 | a Werner Hartman, Lindau Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)li3247we |
700 | 1 | a Manjer, Jonasu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)smi-jma |
700 | 1 | a Olsson, Håkanu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-hol |
700 | 1 | a Grisso, J. A.4 aut |
700 | 1 | a Morgan, M.4 aut |
700 | 1 | a Wheeler, J. E.4 aut |
700 | 1 | a Bunker, C. H.4 aut |
700 | 1 | a Edwards, R. P.4 aut |
700 | 1 | a Modugno, F.4 aut |
700 | 1 | a Peeters, P. H. M.4 aut |
700 | 1 | a Casagrande, J.4 aut |
700 | 1 | a Pike, M. C.4 aut |
700 | 1 | a Ross, R. K.4 aut |
700 | 1 | a Wu, A. H.4 aut |
700 | 1 | a Miller, A. B.4 aut |
700 | 1 | a Kumle, M.4 aut |
700 | 1 | a Gram, I. T.4 aut |
700 | 1 | a Lund, E.4 aut |
700 | 1 | a McGowan, L.4 aut |
700 | 1 | a Shu, X. O.4 aut |
700 | 1 | a Zheng, W.4 aut |
700 | 1 | a Farley, T. M. M.4 aut |
700 | 1 | a Holck, S.4 aut |
700 | 1 | a Meirik, O.4 aut |
700 | 1 | a Risch, H. A.4 aut |
710 | 2 | a Karolinska Institutetb Bröstcancer-genetik4 org |
773 | 0 | t The Lancet Oncologyg 13:9, s. 946-956q 13:9<946-956x 1474-5488 |
856 | 4 | u http://dx.doi.org/10.1016/S1470-2045(12)70322-4x freey FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/3146896 |
856 | 4 8 | u https://doi.org/10.1016/S1470-2045(12)70322-4 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:125207885 |
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