Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling.

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Fältnamn	Indikatorer	Metadata
000		03225naa a2200565 4500
001		oai:DiVA.org:umu-129264
003		SwePub
008		161222s2012 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1292642 URI
024	7	a https://doi.org/10.1016/j.stem.2012.05.0202 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Lee, Dung-Fang4 aut
245	1 0	a Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling.
264	1	b Elsevier BV,c 2012
338		a print2 rdacarrier
520		a Many signals must be integrated to maintain self-renewal and pluripotency in embryonic stem cells (ESCs) and to enable induced pluripotent stem cell (iPSC) reprogramming. However, the exact molecular regulatory mechanisms remain elusive. To unravel the essential internal and external signals required for sustaining the ESC state, we conducted a short hairpin (sh) RNA screen of 104 ESC-associated phosphoregulators. Depletion of one such molecule, aurora kinase A (Aurka), resulted in compromised self-renewal and consequent differentiation. By integrating global gene expression and computational analyses, we discovered that loss of Aurka leads to upregulated p53 activity that triggers ESC differentiation. Specifically, Aurka regulates pluripotency through phosphorylation-mediated inhibition of p53-directed ectodermal and mesodermal gene expression. Phosphorylation of p53 not only impairs p53-induced ESC differentiation but also p53-mediated suppression of iPSC reprogramming. Our studies demonstrate an essential role for Aurka-p53 signaling in the regulation of self-renewal, differentiation, and somatic cell reprogramming.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
700	1	a Su, Jie4 aut
700	1	a Ang, Yen-Sin4 aut
700	1	a Carvajal-Vergara, Xonia4 aut
700	1	a Mulero-Navarro, Sonia4 aut
700	1	a Pereira, Carlos F4 aut
700	1	a Gingold, Julian4 aut
700	1	a Wang, Hung-Liang4 aut
700	1	a Zhao, Ruiying4 aut
700	1	a Sevilla, Ana4 aut
700	1	a Darr, Henia4 aut
700	1	a Williamson, Andrew J K4 aut
700	1	a Chang, Betty4 aut
700	1	a Niu, Xiaohong4 aut
700	1	a Aguilo, Francesca4 aut
700	1	a Flores, Elsa R4 aut
700	1	a Sher, Yuh-Pyng4 aut
700	1	a Hung, Mien-Chie4 aut
700	1	a Whetton, Anthony D4 aut
700	1	a Gelb, Bruce D4 aut
700	1	a Moore, Kateri A4 aut
700	1	a Snoeck, Hans-Willem4 aut
700	1	a Ma'ayan, Avi4 aut
700	1	a Schaniel, Christoph4 aut
700	1	a Lemischka, Ihor R4 aut
773	0	t Cell Stem Celld : Elsevier BVg 11:2q 11:2x 1934-5909x 1875-9777
856	4	u http://www.cell.com/article/S1934590912003396/pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-129264
856	4 8	u https://doi.org/10.1016/j.stem.2012.05.020

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Cell och molekyl ...

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