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High prevalence of ...
High prevalence of undiagnosed comorbidities among adolescents with obesity
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- Leong, Karen S. W. (författare)
- Univ Auckland, Liggins Inst, Auckland, New Zealand; Better Start Natl Sci Challenge, Auckland, New Zealand
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- Jayasinghe, Thilini N. (författare)
- Univ Auckland, Liggins Inst, Auckland, New Zealand
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- Wilson, Brooke C. (författare)
- Univ Auckland, Liggins Inst, Auckland, New Zealand
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- Derraik, José G. B. (författare)
- Uppsala universitet,Perinatal, neonatal och barnkardiologisk forskning,Univ Auckland, Liggins Inst, Auckland, New Zealand; Better Start Natl Sci Challenge, Auckland, New Zealand; Zhejiang Univ, Childrens Hosp, Dept Endocrinol, Sch Med, Hangzhou, Peoples R China
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- Albert, Benjamin B. (författare)
- Univ Auckland, Liggins Inst, Auckland, New Zealand; Better Start Natl Sci Challenge, Auckland, New Zealand
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- Chiavaroli, Valentina (författare)
- Univ Auckland, Liggins Inst, Auckland, New Zealand; Pescara Publ Hosp, Neonatal Intens Care Unit, Pescara, Italy
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- Svirskis, Darren M. (författare)
- Univ Auckland, Fac Med & Hlth Sci, Sch Pharm, Auckland, New Zealand
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- Beck, Kathryn L. (författare)
- Massey Univ, Coll Hlth, Sch Sport Exercise & Nutr, Auckland, New Zealand
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- Conlon, Cathryn A. (författare)
- Massey Univ, Coll Hlth, Sch Sport Exercise & Nutr, Auckland, New Zealand
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- Jiang, Yannan (författare)
- Univ Auckland, Dept Stat, Auckland, New Zealand
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- Schierding, William (författare)
- Univ Auckland, Liggins Inst, Auckland, New Zealand
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- Vatanen, Tommi (författare)
- Univ Auckland, Liggins Inst, Auckland, New Zealand; Broad Inst MIT & Harvard, Cambridge, MA 02142 USA
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- Holland, David J. (författare)
- Counties Manukau Dist Hlth Board, Dept Infect Dis, Auckland, New Zealand
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- O'Sullivan, Justin M. (författare)
- Univ Auckland, Liggins Inst, Auckland, New Zealand; Better Start Natl Sci Challenge, Auckland, New Zealand
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- Cutfield, Wayne S. (författare)
- Univ Auckland, Liggins Inst, Auckland, New Zealand; Better Start Natl Sci Challenge, Auckland, New Zealand; Zhejiang Univ, Childrens Hosp, Dept Endocrinol, Sch Med, Hangzhou, Peoples R China
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(creator_code:org_t)
- 2020-11-18
- 2020
- Engelska.
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Metabolic diseases are increasing among adolescents with obesity. Although the reported prevalence of metabolic syndrome is approximately 30% worldwide, its prevalence is largely unknown among New Zealand adolescents. Therefore, we assessed the health of adolescents with obesity (BMI ≥ 30 kg/m2) enrolled in a randomised clinical trial (Gut Bugs Trial), to identify the prevalence of undiagnosed comorbidities. Assessments included anthropometry, 24-h ambulatory blood pressure monitoring, and insulin sensitivity. We report on baseline data (pre-randomisation) on 87 participants (14–18 years; 59% females), with mean BMI 36.9 ± 5.3 kg/m2 (BMI SDS 3.33 ± 0.79). Approximately 40% of participants had undiagnosed metabolic syndrome, which was twice as common among males. Half (53%) had pre-diabetes and 92% a reduction in insulin sensitivity. Moreover, 31% had pre-hypertension/hypertension, 69% dyslipidaemia, and 25% abnormal liver function. Participants with class III obesity had a greater risk of metabolic syndrome than those with classes I/II [relative risk 1.99 (95% CI 1.19, 3.34)]. Risks for pre-hypertension/hypertension and inflammation were also greater among those with class III obesity. We identified a high prevalence of undiagnosed comorbidities among adolescents with obesity in New Zealand. As adolescent obesity tracks into adulthood, early interventions are needed to prevent progression to overt cardiometabolic diseases.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- Av författaren/redakt...
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Leong, Karen S. ...
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Jayasinghe, Thil ...
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Wilson, Brooke C ...
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Derraik, José G. ...
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Albert, Benjamin ...
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Chiavaroli, Vale ...
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visa fler...
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Svirskis, Darren ...
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Beck, Kathryn L.
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Conlon, Cathryn ...
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Jiang, Yannan
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Schierding, Will ...
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Vatanen, Tommi
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Holland, David J ...
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O'Sullivan, Just ...
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Cutfield, Wayne ...
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MEDICIN OCH HÄLS ...
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MEDICIN OCH HÄLS ...
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Uppsala universitet