Sökning: WFRF:(Wu Jieying) > Mitochondria-target...
Fältnamn | Indikatorer | Metadata |
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000 | 03869naa a2200409 4500 | |
001 | oai:DiVA.org:liu-201378 | |
003 | SwePub | |
008 | 240305s2018 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2013782 URI |
024 | 7 | a https://doi.org/10.1016/j.snb.2017.08.0742 DOI |
040 | a (SwePub)liu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Wang, Huiu Anhui Univ, Peoples R China4 aut |
245 | 1 0 | a Mitochondria-targeted iridium (III) complexes as two-photon fluorogenic probes of cysteine/homocysteine |
264 | 1 | b ELSEVIER SCIENCE SA,c 2018 |
338 | a print2 rdacarrier | |
500 | a Funding Agencies|National Natural Science Foundation of China [51372003, 51432001, 51672002, 21602003, 51472002, 21501001]; Ministry of Education Funded Projects Focus on returned overseas scholar; Higher Education Revitalization Plan Talent Project; Swedish Government Strategic Research Area in Materials Science on Functional Materials at Linkoping University [2009-00971] | |
520 | a Fluorescent imaging of cysteine (Cys) and homocysteine (Hcy) is crucial to understand sulphur metabolism in living cells. Whereas two-photon active cyclometalated Ir(III) complex for detecting Cys/Hcy has been rarely reported. Herein, two novel cyclometalated iridium (III) complexes Ir1-1r2 with different electron-donor were designed, synthesized and fully characterized as well as confirmed by single-crystal X-ray diffraction analysis, which could selectively react with Cys/Hcy, accompanying with an obvious one- and two-photon fluorescence enhancement in vitro. The mechanism for sensing Cys/Hcy was further analyzed in detail by mass spectra and time-dependent density functional theory calculations. It was found that Ir2, bearing ester group, exhibited higher performance on the selective detection of Cys and Hcy compared to In. Notably, the two-photon action cross-section value in the near-infrared region (similar to 800 nm) of Ir2 is significantly enhanced upon the addition of Cys/Hcy. Further application to cellular imaging indicated that Ir2 is membrane permeable and capable of monitoring the changes of intracellular mitochondrial Cys/Hcy. These results support that such two-photon active complexes might provide a promising platform for the detection of mitochondrial Cys/Hcy in living biological systems. (C) 2017 Published by Elsevier B.V. | |
650 | 7 | a NATURVETENSKAPx Fysikx Atom- och molekylfysik och optik0 (SwePub)103022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Physical Sciencesx Atom and Molecular Physics and Optics0 (SwePub)103022 hsv//eng |
653 | a Iridium complexes; Terpyridine; Two-photon fluorescence; Mitochondria; Cysteine; Homocysteine | |
700 | 1 | a Hu, Leiu Anhui Univ, Peoples R China4 aut |
700 | 1 | a Du, Weiu Anhui Univ, Peoples R China4 aut |
700 | 1 | a Tian, Xiaoheu Anhui Univ, Peoples R China4 aut |
700 | 1 | a Hu, Zhangjunu Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten4 aut0 (Swepub:liu)zhahu14 |
700 | 1 | a Zhang, Qiongu Anhui Univ, Peoples R China4 aut |
700 | 1 | a Zhou, Hongpingu Anhui Univ, Peoples R China4 aut |
700 | 1 | a Wu, Jieyingu Anhui Univ, Peoples R China4 aut |
700 | 1 | a Uvdal, Kajsau Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten4 aut0 (Swepub:liu)kajuv09 |
700 | 1 | a Tian, Yupengu Anhui Univ, Peoples R China; Nanjing Univ, Peoples R China4 aut |
710 | 2 | a Anhui Univ, Peoples R Chinab Molekylär ytfysik och nanovetenskap4 org |
773 | 0 | t Sensors and actuators. B, Chemicald : ELSEVIER SCIENCE SAg 255, s. 408-415q 255<408-415x 0925-4005x 1873-3077 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-201378 |
856 | 4 8 | u https://doi.org/10.1016/j.snb.2017.08.074 |
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