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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006753naa a2200673 4500
001oai:DiVA.org:umu-211153
003SwePub
008230703s2023 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2111532 URI
0247 a https://doi.org/10.1126/scitranslmed.adg18552 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Mittler, Evau Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA4 aut
2451 0a Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody
264 1b American Association for the Advancement of Science (AAAS),c 2023
338 a print2 rdacarrier
520 a Emerging rodent-borne hantaviruses cause severe diseases in humans with no approved vaccines or therapeutics. We recently isolated a monoclonal broadly neutralizing antibody (nAb) from a Puumala virus-experienced human donor. Here, we report its structure bound to its target, the Gn/Gc glycoprotein heterodimer comprising the viral fusion complex. The structure explains the broad activity of the nAb: It recognizes conserved Gc fusion loop sequences and the main chain of variable Gn sequences, thereby straddling the Gn/Gc heterodimer and locking it in its prefusion conformation. We show that the nAb's accelerated dissociation from the divergent Andes virus Gn/Gc at endosomal acidic pH limits its potency against this highly lethal virus and correct this liability by engineering an optimized variant that sets a benchmark as a candidate pan-hantavirus therapeutic.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
7001 a Serris, Alexandrau CNRS UMR3569, Structural Virology Unit, Institut Pasteur, Paris, France4 aut
7001 a Esterman, Emma S.u Adimab LLC, Lebanon, NH,USA4 aut
7001 a Florez, Catalinau U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, United States; The Geneva Foundation, Tacoma, WA, USA4 aut
7001 a Polanco, Laura C.u Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA4 aut
7001 a O'Brien, Cecilia M.u U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, United States; The Geneva Foundation, Tacoma, WA, USA4 aut
7001 a Slough, Megan M.u Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA4 aut
7001 a Tynell, Janneu Umeå universitet,Institutionen för klinisk mikrobiologi,Zoonosis Unit, Department of Virology, Medical Faculty, University of Helsinki, Helsinki, Finland4 aut0 (Swepub:umu)jaty0002
7001 a Gröning, Remigiusu Umeå universitet,Institutionen för klinisk mikrobiologi4 aut0 (Swepub:umu)regr0024
7001 a Sun, Yanu Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA4 aut
7001 a Abelson, Dafna M.u Mapp Biopharmaceutical Inc., San Diego, CA, USA4 aut
7001 a Wec, Anna Z.u Adimab LLC, Lebanon, NH, USA4 aut
7001 a Haslwanter, Deniseu Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA4 aut
7001 a Keller, Markusu Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany4 aut
7001 a Ye, Chunyanu Center for Global Health, Department of Internal Medicine, University of New Mexico Health Science Center, Albuquerque, United States4 aut
7001 a Bakken, Russel R.u U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, United States4 aut
7001 a Jangra, Rohit K.u Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA4 aut
7001 a Dye, John M.u U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, United States4 aut
7001 a Ahlm, Clas,d 1956-u Umeå universitet,Institutionen för klinisk mikrobiologi4 aut0 (Swepub:umu)clah0001
7001 a Rappazzo, C. Garrettu Adimab LLC, Lebanon, NH, USA4 aut
7001 a Ulrich, Rainer G.u Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany; Partner site: Hamburg-Lübeck-Borstel-Riems, German Centre for Infection Research (DZIF), Greifswald-Insel Riems, Germany4 aut
7001 a Zeitlin, Larryu Mapp Biopharmaceutical Inc., San Diego, CA, USA4 aut
7001 a Geoghegan, James C.u Adimab LLC, Lebanon, NH, USA4 aut
7001 a Bradfute, Steven B.u Center for Global Health, Department of Internal Medicine, University of New Mexico Health Science Center, Albuquerque, United States4 aut
7001 a Sidoli, Simoneu Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA4 aut
7001 a Forsell, Mattias N. E.u Umeå universitet,Institutionen för klinisk mikrobiologi4 aut0 (Swepub:umu)mafo0173
7001 a Strandin, Tomasu Zoonosis Unit, Department of Virology, Medical Faculty, University of Helsinki, Helsinki, Finland4 aut
7001 a Rey, Felix A.u CNRS UMR3569, Structural Virology Unit, Institut Pasteur, Paris, France4 aut
7001 a Herbert, Andrew S.u U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, United States4 aut
7001 a Walker, Laura M.u Adimab LLC, Lebanon, NH, USA4 aut
7001 a Chandran, Kartiku Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA4 aut
7001 a Guardado-Calvo, Pablou CNRS UMR3569, Structural Virology Unit, Institut Pasteur, Paris, France4 aut
7102 a Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USAb CNRS UMR3569, Structural Virology Unit, Institut Pasteur, Paris, France4 org
7730 t Science Translational Medicined : American Association for the Advancement of Science (AAAS)g 15:700q 15:700x 1946-6234x 1946-6242
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-211153
8564 8u https://doi.org/10.1126/scitranslmed.adg1855

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