Sökning: WFRF:(Zetterberg E.) > Plasma amyloid beta...
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000 | 06565naa a2201513 4500 | |
001 | oai:gup.ub.gu.se/281758 | |
003 | SwePub | |
008 | 240528s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2817582 URI |
024 | 7 | a https://doi.org/10.1016/j.jalz.2019.03.0092 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Vergallo, A.4 aut |
245 | 1 0 | a Plasma amyloid beta 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease |
264 | c 2019-05-18 | |
264 | 1 | b Wiley,c 2019 |
520 | a Introduction: Blood-based biomarkers of pathophysiological brain amyloid beta (A beta) accumulation, particularly for preclinical target and large-scale interventions, are warranted to effectively enrich Alzheimer's disease clinical trials and management. Methods: We investigated whether plasma concentrations of the A beta(1-40)/A beta(1-42) ratio, assessed using the single-molecule array (Simoa) immunoassay, may predict brain A beta positron emission tomography status in a large-scale longitudinal monocentric cohort (N = 276) of older individuals with subjective memory complaints. We performed a hypothesis-driven investigation followed by a no-apriori hypothesis study using machine learning. Results: The receiver operating characteristic curve and machine learning showed a balanced accuracy of 76.5% and 81%, respectively, for the plasma A beta(1-40)/A beta(1-42) ratio. The accuracy is not affected by the apolipoprotein E (APOE) epsilon 4 allele, sex, or age. Discussion: Our results encourage an independent validation cohort study to confirm the indication that the plasma A beta(1-40)/A beta(1-42) ratio, assessed via Simoa, may improve future standard of care and clinical trial design. (C) 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
653 | a Alzheimer's disease | |
653 | a Plasma amyloid beta | |
653 | a Simoa immunoassay | |
653 | a Machine learning | |
653 | a Subjective | |
653 | a blood-based biomarkers | |
653 | a decline | |
653 | a progression | |
700 | 1 | a Megret, L.4 aut |
700 | 1 | a Lista, S.4 aut |
700 | 1 | a Cavedo, E.4 aut |
700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
700 | 1 | a Vanmechelen, E.4 aut |
700 | 1 | a De Vos, A.4 aut |
700 | 1 | a Habert, M. O.4 aut |
700 | 1 | a Potier, M. C.4 aut |
700 | 1 | a Dubois, B.4 aut |
700 | 1 | a Neri, C.4 aut |
700 | 1 | a Hampel, H.4 aut |
700 | 1 | a Dubois, B.4 aut |
700 | 1 | a Hampel, H.4 aut |
700 | 1 | a Bakardjian, H.4 aut |
700 | 1 | a Benali, H.4 aut |
700 | 1 | a Colliot, O.4 aut |
700 | 1 | a Marie-O, H.4 aut |
700 | 1 | a Lamari, F.4 aut |
700 | 1 | a Mochel, F.4 aut |
700 | 1 | a Potier, M. C.4 aut |
700 | 1 | a de Schotten, M. T.4 aut |
700 | 1 | a Afshar, M.4 aut |
700 | 1 | a Aguilar, L. F.4 aut |
700 | 1 | a Akman-Anderson, L.4 aut |
700 | 1 | a Arenas, J.4 aut |
700 | 1 | a Avila, J.4 aut |
700 | 1 | a Babiloni, C.4 aut |
700 | 1 | a Baldacci, F.4 aut |
700 | 1 | a Batrla, R.4 aut |
700 | 1 | a Benda, N.4 aut |
700 | 1 | a Black, K. L.4 aut |
700 | 1 | a Bokde, A. L. W.4 aut |
700 | 1 | a Bonuccelli, U.4 aut |
700 | 1 | a Broich, K.4 aut |
700 | 1 | a Cacciola, F.4 aut |
700 | 1 | a Caraci, F.4 aut |
700 | 1 | a Castrillo, J.4 aut |
700 | 1 | a Cavedo, E.4 aut |
700 | 1 | a Ceravolo, R.4 aut |
700 | 1 | a Chiesa, P. A.4 aut |
700 | 1 | a Corvol, J. C.4 aut |
700 | 1 | a Cuello, A. C.4 aut |
700 | 1 | a Cummings, J. L.4 aut |
700 | 1 | a Depypere, H.4 aut |
700 | 1 | a Dubois, B.4 aut |
700 | 1 | a Duggento, A.4 aut |
700 | 1 | a Emanuele, E.4 aut |
700 | 1 | a Escott-Price, V.4 aut |
700 | 1 | a Federoff, H.4 aut |
700 | 1 | a Ferretti, M. T.4 aut |
700 | 1 | a Fiandaca, M.4 aut |
700 | 1 | a Frank, R. A.4 aut |
700 | 1 | a Garaci, F.4 aut |
700 | 1 | a Geerts, H.4 aut |
700 | 1 | a Giorgi, F. S.4 aut |
700 | 1 | a Goetzl, E. J.4 aut |
700 | 1 | a Graziani, M.4 aut |
700 | 1 | a Haberkamp, M.4 aut |
700 | 1 | a Habert, M. O.4 aut |
700 | 1 | a Hampel, H.4 aut |
700 | 1 | a Herholz, K.4 aut |
700 | 1 | a Hernandez, F.4 aut |
700 | 1 | a Kapogiannis, D.4 aut |
700 | 1 | a Karran, E.4 aut |
700 | 1 | a Kiddle, S. J.4 aut |
700 | 1 | a Kim, S. H.4 aut |
700 | 1 | a Koronyo, Y.4 aut |
700 | 1 | a Koronyo-Hamaoui, M.4 aut |
700 | 1 | a Langevin, T.4 aut |
700 | 1 | a Lehericy, S.4 aut |
700 | 1 | a Lucia, A.4 aut |
700 | 1 | a Lista, S.4 aut |
700 | 1 | a Lorenceau, J.4 aut |
700 | 1 | a Mango, D.4 aut |
700 | 1 | a Mapstone, M.4 aut |
700 | 1 | a Neri, C.4 aut |
700 | 1 | a Nistico, R.4 aut |
700 | 1 | a O'Bryant, S. E.4 aut |
700 | 1 | a Palmero, G.4 aut |
700 | 1 | a Perry, G.4 aut |
700 | 1 | a Ritchie, C.4 aut |
700 | 1 | a Rossi, S.4 aut |
700 | 1 | a Saidi, A.4 aut |
700 | 1 | a Santarnecchi, E.4 aut |
700 | 1 | a Schneider, L. S.4 aut |
700 | 1 | a Sporns, O.4 aut |
700 | 1 | a Toschi, N.4 aut |
700 | 1 | a Verdooner, S. R.4 aut |
700 | 1 | a Vergallo, A.4 aut |
700 | 1 | a Villain, N.4 aut |
700 | 1 | a Welikovitch, L. A.4 aut |
700 | 1 | a Woodcock, J.4 aut |
700 | 1 | a Younesi, E.4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Alzheimers & Dementiad : Wileyg 15:6, s. 764-775q 15:6<764-775x 1552-5260x 1552-5279 |
856 | 4 | u https://hal.archives-ouvertes.fr/hal-03484725/file/S1552526019300822.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/281758 |
856 | 4 8 | u https://doi.org/10.1016/j.jalz.2019.03.009 |
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