Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development

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Fältnamn	Indikatorer	Metadata
000		08132naa a2201453 4500
001		oai:DiVA.org:umu-170950
003		SwePub
008		200519s2019 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:05595499-b514-4827-a203-33df74691d7c
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1709502 URI
024	7	a https://doi.org/10.18632/oncotarget.266782 DOI
024	7	a https://lup.lub.lu.se/record/05595499-b514-4827-a203-33df74691d7c2 URI
040		a (SwePub)umud (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Li, Yafangu Baylor College of Medicine4 aut
245	1 0	a Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development
264		c 2019-03-05
264	1	b Impact Journals, LLC,c 2019
338		a electronic2 rdacarrier
520		a The development of cancer is driven by the accumulation of many oncogenesis-related genetic alterations and tumorigenesis is triggered by complex networks of involved genes rather than independent actions. To explore the epistasis existing among oncogenesis-related genes in lung cancer development, we conducted pairwise genetic interaction analyses among 35,031 SNPs from 2027 oncogenesis-related genes. The genotypes from three independent genome-wide association studies including a total of 24,037 lung cancer patients and 20,401 healthy controls with Caucasian ancestry were analyzed in the study. Using a two-stage study design including discovery and replication studies, and stringent Bonferroni correction for multiple statistical analysis, we identified significant genetic interactions between SNPs in RGL1:RAD51B (OR=0.44, p value=3.27x10-11 in overall lung cancer and OR=0.41, p value=9.71x10-11 in non-small cell lung cancer), SYNE1:RNF43 (OR=0.73, p value=1.01x10-12 in adenocarcinoma) and FHIT:TSPAN8 (OR=1.82, p value=7.62x10-11 in squamous cell carcinoma) in our analysis. None of these genes have been identified from previous main effect association studies in lung cancer. Further eQTL gene expression analysis in lung tissues provided information supporting the functional role of the identified epistasis in lung tumorigenesis. Gene set enrichment analysis revealed potential pathways and gene networks underlying molecular mechanisms in overall lung cancer as well as histology subtypes development. Our results provide evidence that genetic interactions between oncogenesis-related genes play an important role in lung tumorigenesis and epistasis analysis, combined with functional annotation, provides a valuable tool for uncovering functional novel susceptibility genes that contribute to lung cancer development by interacting with other modifier genes.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653		a epistasis
653		a functional annotation
653		a lung cancer
653		a oncogenesis
653		a Epistasis
653		a Functional annotation
653		a Lung cancer
653		a Oncogenesis
700	1	a Xiao, Xiangjun4 aut
700	1	a Bossé, Yohan4 aut
700	1	a Gorlova, Olga4 aut
700	1	a Gorlov, Ivan4 aut
700	1	a Han, Younghun4 aut
700	1	a Byun, Jinyoung4 aut
700	1	a Leighl, Natasha4 aut
700	1	a Johansen, Jakob S.4 aut
700	1	a Barnett, Matt4 aut
700	1	a Chen, Chu4 aut
700	1	a Goodman, Gary4 aut
700	1	a Cox, Angela4 aut
700	1	a Taylor, Fiona4 aut
700	1	a Woll, Penella4 aut
700	1	a Wichmann, H. Erich4 aut
700	1	a Manz, Judith4 aut
700	1	a Muley, Thomas4 aut
700	1	a Risch, Angela4 aut
700	1	a Rosenberger, Albert4 aut
700	1	a Han, Jiali4 aut
700	1	a Siminovitch, Katherine4 aut
700	1	a Arnold, Susanne M.4 aut
700	1	a Haura, Eric B.4 aut
700	1	a Bolca, Ciprian4 aut
700	1	a Holcatova, Ivana4 aut
700	1	a Janout, Vladimir4 aut
700	1	a Kontic, Milica4 aut
700	1	a Lissowska, Jolanta4 aut
700	1	a Mukeria, Anush4 aut
700	1	a Ognjanovic, Simona4 aut
700	1	a Orlowski, Tadeusz M.4 aut
700	1	a Scelo, Ghislaine4 aut
700	1	a Swiatkowska, Beata4 aut
700	1	a Zaridze, David4 aut
700	1	a Bakke, Per4 aut
700	1	a Skaug, Vidar4 aut
700	1	a Zienolddiny, Shanbeh4 aut
700	1	a Duell, Eric J.4 aut
700	1	a Butler, Lesley M.4 aut
700	1	a Houlston, Richard4 aut
700	1	a Artigas, María Soler4 aut
700	1	a Grankvist, Kjellu Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)kjgr0002
700	1	a Johansson, Mikaelu Umeå universitet,Onkologi4 aut0 (Swepub:umu)mijo0025
700	1	a Shepherd, Frances A.4 aut
700	1	a Marcus, Michael W.4 aut
700	1	a Brunnström, Hansu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups4 aut0 (Swepub:lu)med-hsb
700	1	a Manjer, Jonasu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)smi-jma
700	1	a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
700	1	a Muller, David C.4 aut
700	1	a Overvad, Kim4 aut
700	1	a Trichopoulou, Antonia4 aut
700	1	a Tumino, Rosario4 aut
700	1	a Liu, Geoffrey4 aut
700	1	a Bojesen, Stig E.4 aut
700	1	a Wu, Xifeng4 aut
700	1	a Le Marchand, Loic4 aut
700	1	a Albanes, Demetrios4 aut
700	1	a Bickeböller, Heike4 aut
700	1	a Aldrich, Melinda C.4 aut
700	1	a Bush, William S.4 aut
700	1	a Tardon, Adonina4 aut
700	1	a Rennert, Gad4 aut
700	1	a Teare, M. Dawn4 aut
700	1	a Field, John K.4 aut
700	1	a Kiemeney, Lambertus A.4 aut
700	1	a Lazarus, Philip4 aut
700	1	a Haugen, Aage4 aut
700	1	a Lam, Stephen4 aut
700	1	a Schabath, Matthew B.4 aut
700	1	a Andrew, Angeline S.4 aut
700	1	a Bertazzi, Pier Alberto4 aut
700	1	a Pesatori, Angela C.4 aut
700	1	a Christiani, David C.4 aut
700	1	a Caporaso, Neil4 aut
700	1	a Johansson, Mattias4 aut
700	1	a McKay, James D.4 aut
700	1	a Brennan, Paul4 aut
700	1	a Hung, Rayjean J.4 aut
700	1	a Amos, Christopher I.u Dartmouth College4 aut
710	2	a Baylor College of Medicineb Klinisk kemi4 org
710	2	a et al.
773	0	t Oncotargetd : Impact Journals, LLCg 10:19, s. 1760-1774q 10:19<1760-1774x 1949-2553
856	4	u https://doi.org/10.18632/oncotarget.26678y Fulltext
856	4	u https://umu.diva-portal.org/smash/get/diva2:1431069/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://www.oncotarget.com/article/26678/pdf/
856	4	u http://dx.doi.org/10.18632/oncotarget.26678x freey FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-170950
856	4 8	u https://doi.org/10.18632/oncotarget.26678
856	4 8	u https://lup.lub.lu.se/record/05595499-b514-4827-a203-33df74691d7c

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Av författaren/redakt...: Li, Yafang; Xiao, Xiangjun; Bossé, Yohan; Gorlova, Olga; Gorlov, Ivan; Han, Younghun; visa fler...; Byun, Jinyoung; Leighl, Natasha; Johansen, Jakob ...; Barnett, Matt; Chen, Chu; Goodman, Gary; Cox, Angela; Taylor, Fiona; Woll, Penella; Wichmann, H. Eri ...; Manz, Judith; Muley, Thomas; Risch, Angela; Rosenberger, Alb ...; Han, Jiali; Siminovitch, Kat ...; Arnold, Susanne ...; Haura, Eric B.; Bolca, Ciprian; Holcatova, Ivana; Janout, Vladimir; Kontic, Milica; Lissowska, Jolan ...; Mukeria, Anush; Ognjanovic, Simo ...; Orlowski, Tadeus ...; Scelo, Ghislaine; Swiatkowska, Bea ...; Zaridze, David; Bakke, Per; Skaug, Vidar; Zienolddiny, Sha ...; Duell, Eric J.; Butler, Lesley M ...; Houlston, Richar ...; Artigas, María S ...; Grankvist, Kjell; Johansson, Mikae ...; Shepherd, France ...; Marcus, Michael ...; Brunnström, Hans; Manjer, Jonas; Melander, Olle; Muller, David C.; Overvad, Kim; Trichopoulou, An ...; Tumino, Rosario; Liu, Geoffrey; Bojesen, Stig E.; Wu, Xifeng; Le Marchand, Loi ...; Albanes, Demetri ...; Bickeböller, Hei ...; Aldrich, Melinda ...; Bush, William S.; Tardon, Adonina; Rennert, Gad; Teare, M. Dawn; Field, John K.; Kiemeney, Lamber ...; Lazarus, Philip; Haugen, Aage; Lam, Stephen; Schabath, Matthe ...; Andrew, Angeline ...; Bertazzi, Pier A ...; Pesatori, Angela ...; Christiani, Davi ...; Caporaso, Neil; Johansson, Matti ...; McKay, James D.; Brennan, Paul; Hung, Rayjean J.; Amos, Christophe ...; visa färre...

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