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  • Drakvik, E.Karolinska Institutet, Institute of Environmental Medicine, Nobels väg 13, SE-171 77 Stockholm, Sweden; Stockholm University, ACES, Stockholm, Sweden,Karolinska Inst, Inst Environm Med, Nobels Vag 13, SE-17177 Stockholm, Sweden;Stockholm Univ, ACES, SE-10691 Stockholm, Sweden (författare)

Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2020

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/293292
  • https://gup.ub.gu.se/publication/293292URI
  • https://doi.org/10.1016/j.envint.2019.105267DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-77877URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-401998URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:142480820URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • The number of anthropogenic chemicals, manufactured, by-products, metabolites and abiotically formed transformation products, counts to hundreds of thousands, at present. Thus, humans and wildlife are exposed to complex mixtures, never one chemical at a time and rarely with only one dominating effect. Hence there is an urgent need to develop strategies on how exposure to multiple hazardous chemicals and the combination of their effects can be assessed. A workshop, “Advancing the Assessment of Chemical Mixtures and their Risks for Human Health and the Environment” was organized in May 2018 together with Joint Research Center in Ispra, EU-funded research projects and Commission Services and relevant EU agencies. This forum for researchers and policy-makers was created to discuss and identify gaps in risk assessment and governance of chemical mixtures as well as to discuss state of the art science and future research needs. Based on the presentations and discussions at this workshop we want to bring forward the following Key Messages: • We are at a turning point: multiple exposures and their combined effects require better management to protect public health and the environment from hazardous chemical mixtures. • Regulatory initiatives should be launched to investigate the opportunities for all relevant regulatory frameworks to include prospective mixture risk assessment and consider combined exposures to (real-life) chemical mixtures to humans and wildlife, across sectors. • Precautionary approaches and intermediate measures (e.g. Mixture Assessment Factor) can already be applied, although, definitive mixture risk assessments cannot be routinely conducted due to significant knowledge and data gaps. • A European strategy needs to be set, through stakeholder engagement, for the governance of combined exposure to multiple chemicals and mixtures. The strategy would include research aimed at scientific advancement in mechanistic understanding and modelling techniques, as well as research to address regulatory and policy needs. Without such a clear strategy, specific objectives and common priorities, research, and policies to address mixtures will likely remain scattered and insufficient. © 2019 The Authors

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Altenburger, R.Helmholtz Centre for Environmental Research UFZ, Leipzig, Germany,UFZ Helmholtz Ctr Environm Res, Permoserstr 15, D-04318 Leipzig, Germany (författare)
  • Aoki, Y.National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan,Natl Inst Environm Studies, 16-2 Onogawa, Tsukuba, Ibaraki 3058506, Japan (författare)
  • Backhaus, Thomas,1967Gothenburg University,Göteborgs universitet,Institutionen för biologi och miljövetenskap,Department of Biological and Environmental Sciences,University of Gothenburg, Department of Biological and Environmental Sciences, Gothenburg, Sweden,Univ Gothenburg, Dept Biol & Environm Sci, Box 461, SE-40530 Gothenburg, Sweden(Swepub:gu)xbacth (författare)
  • Bahadori, T.US Environmental Protection Agency, 1200 Pennsylvania Ave, NW, MC 8201R, Washington, DC, USA,US EPA, 1200 Penn Ave NW,MC 8201R, Washington, DC 20460 USA (författare)
  • Barouki, R.Université de Paris, Inserm Unit 1124, Paris, France,Univ Paris, Inserm Unit 1124, 45 Rue St Peres, F-75006 Paris, France (författare)
  • Brack, W.Helmholtz Centre for Environmental Research UFZ, Leipzig, Germany; RWTH Aachen University Institute for Environmental Research, ABBt-aachen Biology, Aachen, Germany,UFZ Helmholtz Ctr Environm Res, Permoserstr 15, D-04318 Leipzig, Germany;Rhein Westfal TH Aachen, Inst Environm Res, ABBt Aachen Biol, Worringerweg 1, D-52074 Aachen, Germany (författare)
  • Cronin, M. T. D.Liverpool John Moores University, School of Pharmacy and Biomolecular Sciences, Byrom Street, Liverpool, UK,Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Byrom St, Liverpool L3 3AF, Merseyside, England (författare)
  • Demeneix, B.Muséum National d'Histoire Naturelle (MNHN) UMR 7221 (CNRS/MNHN), Paris, France,CNRS, MNHN, UMR 7221, 7 Rue Cuvier, F-75005 Paris, France (författare)
  • Hougaard Bennekou, S.Danish Technical University, FOOD, Kemitorvet 201. Lyngby, Denmark,Danish Tech Univ, FOOD, Kemitorvet 201, DK-2800 Lyngby, Denmark (författare)
  • van Klaveren, J.National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands,Natl Inst Publ Hlth & Environm RIVM, POB 1, NL-3720 BA Bilthoven, Netherlands (författare)
  • Kneuer, C.German Federal Institute for Risk Assessment, Pesticide Safety, German Federal Institute for Risk Assessment, Berlin, Germany,German Fed Inst Risk Assessment, Pesticide Safety, Max Dohrn Str 8-10, D-10589 Berlin, Germany (författare)
  • Kolossa-Gehring, M.German Environment Agency (UBA), Berlin, Germany,German Environm Agcy UBA, Correnspl 1, D-14195 Berlin, Germany (författare)
  • Lebret, E.National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands; Institute of Risk Assessment Sciences - IRAS, Utrecht University, Utrecht, the Netherlands,Natl Inst Publ Hlth & Environm RIVM, POB 1, NL-3720 BA Bilthoven, Netherlands;Univ Utrecht, IRAS, Yalelaan 2, NL-3584 CM Utrecht, Netherlands (författare)
  • Posthuma, L.National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands; Radboud University, Department of Environmental Science, Institute for Water and Wetland Research, Nijmegen, the Netherlands,Natl Inst Publ Hlth & Environm RIVM, POB 1, NL-3720 BA Bilthoven, Netherlands;Radboud Univ Nijmegen, Dept Environm Sci, Inst Water & Wetland Res, Nijmegen, Netherlands (författare)
  • Reiber, L.German Environment Agency (UBA), Berlin, Germany,German Environm Agcy UBA, Correnspl 1, D-14195 Berlin, Germany (författare)
  • Rider, C.National Toxicology Program, National Institute of Environmental Health Sciences, 111 TW Alexander Drive, PO Box 12233, MD:K2-12, Research Triangle Park, NC, USA,NIEHS, Natl Toxicol Program, 111 TW Alexander Dr,POB 12233,MD K2-12, Res Triangle Pk, NC 27709 USA (författare)
  • Ruegg, JoëlleKarolinska Institutet,Uppsala universitet,Miljötoxikologi,Karolinska Inst, Inst Environm Med, Nobels Vag 13, SE-17177 Stockholm, Sweden(Swepub:uu)joeru493 (författare)
  • Testa, G.University of Milan, Department of Oncology, Via S. Sofia, 9/1, 20122 Milan, Italy; IEO European Institute of Oncology, Milan, Italy,Univ Milan, Dept Oncol, Via S Sofia 9-1, I-20122 Milan, Italy;IEO, Via Adamello 16, I-20139 Milan, Italy (författare)
  • van der Burg, B.BioDetection Systems, Amsterdam, the Netherlands,BioDetect Syst, Sci Pk 406, NL-1098 XH Amsterdam, Netherlands (författare)
  • van der Voet, H.Wageningen University & Research, Wageningen, the Netherlands,Wageningen Univ & Res, Droevendaalsesteeg 1, NL-6708 PB Wageningen, Netherlands (författare)
  • Warhurst, A. M.CHEM Trust, 34b York Way, London N1 9AB, England (författare)
  • van de Water, B.Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands,Leiden Univ, Leiden Acad Ctr Drug Res, POB 9502, NL-2300 RA Leiden, Netherlands (författare)
  • Yamazaki, K.Ministry of the Environment, Japan, Chiyoda-ku, Tokyo, Japan,Minist Environm Japan, Chiyoda Ku, 1-2-2 Kasumigaseki, Tokyo 1008975, Japan (författare)
  • Öberg, M.Karolinska Institutet (författare)
  • Bergman, Åke,1950-Örebro universitet,Institutionen för naturvetenskap och teknik,Stockholm University, ACES, Stockholm, Sweden; State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai, China,Stockholm Univ, ACES, SE-10691 Stockholm, Sweden;Orebro Univ, Dept Sci & Technol, SE-70182 Orebro, Sweden;Tongji Univ, Coll Environm Sci & Engn, State Key Lab Pollut Control & Resource Reuse, Shanghai 200092, Peoples R China(Swepub:oru)akbn (författare)
  • Karolinska Institutet, Institute of Environmental Medicine, Nobels väg 13, SE-171 77 Stockholm, Sweden; Stockholm University, ACES, Stockholm, SwedenKarolinska Inst, Inst Environm Med, Nobels Vag 13, SE-17177 Stockholm, Sweden;Stockholm Univ, ACES, SE-10691 Stockholm, Sweden (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Environment International: Elsevier BV1340160-41201873-6750

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