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FältnamnIndikatorerMetadata
00011399naa a2201033 4500
001oai:gup.ub.gu.se/293292
003SwePub
008240528s2020 | |||||||||||000 ||eng|
009oai:DiVA.org:oru-77877
009oai:DiVA.org:uu-401998
009oai:prod.swepub.kib.ki.se:142480820
024a https://gup.ub.gu.se/publication/2932922 URI
024a https://doi.org/10.1016/j.envint.2019.1052672 DOI
024a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-778772 URI
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4019982 URI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1424808202 URI
040 a (SwePub)gud (SwePub)orud (SwePub)uud (SwePub)ki
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Drakvik, E.u Karolinska Institutet, Institute of Environmental Medicine, Nobels väg 13, SE-171 77 Stockholm, Sweden; Stockholm University, ACES, Stockholm, Sweden,Karolinska Inst, Inst Environm Med, Nobels Vag 13, SE-17177 Stockholm, Sweden;Stockholm Univ, ACES, SE-10691 Stockholm, Sweden4 aut
2451 0a Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment
264 1b Elsevier BV,c 2020
520 a The number of anthropogenic chemicals, manufactured, by-products, metabolites and abiotically formed transformation products, counts to hundreds of thousands, at present. Thus, humans and wildlife are exposed to complex mixtures, never one chemical at a time and rarely with only one dominating effect. Hence there is an urgent need to develop strategies on how exposure to multiple hazardous chemicals and the combination of their effects can be assessed. A workshop, “Advancing the Assessment of Chemical Mixtures and their Risks for Human Health and the Environment” was organized in May 2018 together with Joint Research Center in Ispra, EU-funded research projects and Commission Services and relevant EU agencies. This forum for researchers and policy-makers was created to discuss and identify gaps in risk assessment and governance of chemical mixtures as well as to discuss state of the art science and future research needs. Based on the presentations and discussions at this workshop we want to bring forward the following Key Messages: • We are at a turning point: multiple exposures and their combined effects require better management to protect public health and the environment from hazardous chemical mixtures. • Regulatory initiatives should be launched to investigate the opportunities for all relevant regulatory frameworks to include prospective mixture risk assessment and consider combined exposures to (real-life) chemical mixtures to humans and wildlife, across sectors. • Precautionary approaches and intermediate measures (e.g. Mixture Assessment Factor) can already be applied, although, definitive mixture risk assessments cannot be routinely conducted due to significant knowledge and data gaps. • A European strategy needs to be set, through stakeholder engagement, for the governance of combined exposure to multiple chemicals and mixtures. The strategy would include research aimed at scientific advancement in mechanistic understanding and modelling techniques, as well as research to address regulatory and policy needs. Without such a clear strategy, specific objectives and common priorities, research, and policies to address mixtures will likely remain scattered and insufficient. © 2019 The Authors
650 7a NATURVETENSKAPx Geovetenskap och miljövetenskapx Miljövetenskap0 (SwePub)105022 hsv//swe
650 7a NATURAL SCIENCESx Earth and Related Environmental Sciencesx Environmental Sciences0 (SwePub)105022 hsv//eng
653 a Chemical mixtures
653 a Combined exposure
653 a Environmental chemicals
653 a Mixture risk assessment
653 a Risk management
653 a Animals
653 a Environmental management
653 a Hazardous materials
653 a Hazards
653 a Health risks
653 a Indicators (chemical)
653 a Metabolites
653 a Mixtures
653 a Pollution control
653 a Public health
653 a Anthropogenic chemicals
653 a Joint Research centers
653 a Precautionary approach
653 a Stakeholder engagement
653 a Transformation products
653 a Risk assessment
653 a dangerous goods
653 a drug mixture
653 a human
653 a letter
653 a wildlife
653 a Chemical mixtures
700a Altenburger, R.u Helmholtz Centre for Environmental Research UFZ, Leipzig, Germany,UFZ Helmholtz Ctr Environm Res, Permoserstr 15, D-04318 Leipzig, Germany4 aut
700a Aoki, Y.u National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan,Natl Inst Environm Studies, 16-2 Onogawa, Tsukuba, Ibaraki 3058506, Japan4 aut
700a Backhaus, Thomas,d 1967u Gothenburg University,Göteborgs universitet,Institutionen för biologi och miljövetenskap,Department of Biological and Environmental Sciences,University of Gothenburg, Department of Biological and Environmental Sciences, Gothenburg, Sweden,Univ Gothenburg, Dept Biol & Environm Sci, Box 461, SE-40530 Gothenburg, Sweden4 aut0 (Swepub:gu)xbacth
700a Bahadori, T.u US Environmental Protection Agency, 1200 Pennsylvania Ave, NW, MC 8201R, Washington, DC, USA,US EPA, 1200 Penn Ave NW,MC 8201R, Washington, DC 20460 USA4 aut
700a Barouki, R.u Université de Paris, Inserm Unit 1124, Paris, France,Univ Paris, Inserm Unit 1124, 45 Rue St Peres, F-75006 Paris, France4 aut
700a Brack, W.u Helmholtz Centre for Environmental Research UFZ, Leipzig, Germany; RWTH Aachen University Institute for Environmental Research, ABBt-aachen Biology, Aachen, Germany,UFZ Helmholtz Ctr Environm Res, Permoserstr 15, D-04318 Leipzig, Germany;Rhein Westfal TH Aachen, Inst Environm Res, ABBt Aachen Biol, Worringerweg 1, D-52074 Aachen, Germany4 aut
700a Cronin, M. T. D.u Liverpool John Moores University, School of Pharmacy and Biomolecular Sciences, Byrom Street, Liverpool, UK,Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Byrom St, Liverpool L3 3AF, Merseyside, England4 aut
700a Demeneix, B.u Muséum National d'Histoire Naturelle (MNHN) UMR 7221 (CNRS/MNHN), Paris, France,CNRS, MNHN, UMR 7221, 7 Rue Cuvier, F-75005 Paris, France4 aut
700a Hougaard Bennekou, S.u Danish Technical University, FOOD, Kemitorvet 201. Lyngby, Denmark,Danish Tech Univ, FOOD, Kemitorvet 201, DK-2800 Lyngby, Denmark4 aut
700a van Klaveren, J.u National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands,Natl Inst Publ Hlth & Environm RIVM, POB 1, NL-3720 BA Bilthoven, Netherlands4 aut
700a Kneuer, C.u German Federal Institute for Risk Assessment, Pesticide Safety, German Federal Institute for Risk Assessment, Berlin, Germany,German Fed Inst Risk Assessment, Pesticide Safety, Max Dohrn Str 8-10, D-10589 Berlin, Germany4 aut
700a Kolossa-Gehring, M.u German Environment Agency (UBA), Berlin, Germany,German Environm Agcy UBA, Correnspl 1, D-14195 Berlin, Germany4 aut
700a Lebret, E.u National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands; Institute of Risk Assessment Sciences - IRAS, Utrecht University, Utrecht, the Netherlands,Natl Inst Publ Hlth & Environm RIVM, POB 1, NL-3720 BA Bilthoven, Netherlands;Univ Utrecht, IRAS, Yalelaan 2, NL-3584 CM Utrecht, Netherlands4 aut
700a Posthuma, L.u National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands; Radboud University, Department of Environmental Science, Institute for Water and Wetland Research, Nijmegen, the Netherlands,Natl Inst Publ Hlth & Environm RIVM, POB 1, NL-3720 BA Bilthoven, Netherlands;Radboud Univ Nijmegen, Dept Environm Sci, Inst Water & Wetland Res, Nijmegen, Netherlands4 aut
700a Reiber, L.u German Environment Agency (UBA), Berlin, Germany,German Environm Agcy UBA, Correnspl 1, D-14195 Berlin, Germany4 aut
700a Rider, C.u National Toxicology Program, National Institute of Environmental Health Sciences, 111 TW Alexander Drive, PO Box 12233, MD:K2-12, Research Triangle Park, NC, USA,NIEHS, Natl Toxicol Program, 111 TW Alexander Dr,POB 12233,MD K2-12, Res Triangle Pk, NC 27709 USA4 aut
700a Ruegg, Joëlleu Karolinska Institutet,Uppsala universitet,Miljötoxikologi,Karolinska Inst, Inst Environm Med, Nobels Vag 13, SE-17177 Stockholm, Sweden4 aut0 (Swepub:uu)joeru493
700a Testa, G.u University of Milan, Department of Oncology, Via S. Sofia, 9/1, 20122 Milan, Italy; IEO European Institute of Oncology, Milan, Italy,Univ Milan, Dept Oncol, Via S Sofia 9-1, I-20122 Milan, Italy;IEO, Via Adamello 16, I-20139 Milan, Italy4 aut
700a van der Burg, B.u BioDetection Systems, Amsterdam, the Netherlands,BioDetect Syst, Sci Pk 406, NL-1098 XH Amsterdam, Netherlands4 aut
700a van der Voet, H.u Wageningen University & Research, Wageningen, the Netherlands,Wageningen Univ & Res, Droevendaalsesteeg 1, NL-6708 PB Wageningen, Netherlands4 aut
700a Warhurst, A. M.u CHEM Trust, 34b York Way, London N1 9AB, England4 aut
700a van de Water, B.u Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands,Leiden Univ, Leiden Acad Ctr Drug Res, POB 9502, NL-2300 RA Leiden, Netherlands4 aut
700a Yamazaki, K.u Ministry of the Environment, Japan, Chiyoda-ku, Tokyo, Japan,Minist Environm Japan, Chiyoda Ku, 1-2-2 Kasumigaseki, Tokyo 1008975, Japan4 aut
700a Öberg, M.u Karolinska Institutet4 aut
700a Bergman, Åke,d 1950-u Örebro universitet,Institutionen för naturvetenskap och teknik,Stockholm University, ACES, Stockholm, Sweden; State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai, China,Stockholm Univ, ACES, SE-10691 Stockholm, Sweden;Orebro Univ, Dept Sci & Technol, SE-70182 Orebro, Sweden;Tongji Univ, Coll Environm Sci & Engn, State Key Lab Pollut Control & Resource Reuse, Shanghai 200092, Peoples R China4 aut0 (Swepub:oru)akbn
710a Karolinska Institutet, Institute of Environmental Medicine, Nobels väg 13, SE-171 77 Stockholm, Sweden; Stockholm University, ACES, Stockholm, Swedenb Karolinska Inst, Inst Environm Med, Nobels Vag 13, SE-17177 Stockholm, Sweden;Stockholm Univ, ACES, SE-10691 Stockholm, Sweden4 org
773t Environment Internationald : Elsevier BVg 134q 134x 0160-4120x 1873-6750
856u https://doi.org/10.1016/j.envint.2019.105267
856u https://doi.org/10.1016/j.envint.2019.105267y Fulltext
856u https://uu.diva-portal.org/smash/get/diva2:1384687/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://gup.ub.gu.se/publication/293292
8564 8u https://doi.org/10.1016/j.envint.2019.105267
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-77877
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-401998
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:142480820

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