Sökning: onr:"swepub:oai:gup.ub.gu.se/260615" > Excess morbidity an...
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000 | 05275naa a2200817 4500 | |
001 | oai:gup.ub.gu.se/260615 | |
003 | SwePub | |
008 | 240528s2018 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2606152 URI |
024 | 7 | a https://doi.org/10.1530/EJE-17-07072 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Wijnen, Mark4 aut |
245 | 1 0 | a Excess morbidity and mortality in patients with craniopharyngioma: a hospital-based retrospective cohort study. |
264 | 1 | c 2018 |
520 | a Most studies in patients with craniopharyngioma did not investigate morbidity and mortality relative to the general population nor evaluated risk factors for excess morbidity and mortality. Therefore, the objective of this study was to examine excess morbidity and mortality, as well as their determinants in patients with craniopharyngioma.Hospital-based retrospective cohort study conducted between 1987 and 2014.We included 144 Dutch and 80 Swedish patients with craniopharyngioma identified by a computer-based search in the medical records (105 females (47%), 112 patients with childhood-onset craniopharyngioma (50%), 3153 person-years of follow-up). Excess morbidity and mortality were analysed using standardized incidence and mortality ratios (SIRs and SMRs). Risk factors were evaluated univariably by comparing SIRs and SMRs between non-overlapping subgroups.Patients with craniopharyngioma experienced excess morbidity due to type 2 diabetes mellitus (T2DM) (SIR: 4.4, 95% confidence interval (CI): 2.8-6.8) and cerebral infarction (SIR: 4.9, 95% CI: 3.1-8.0) compared to the general population. Risks for malignant neoplasms, myocardial infarctions and fractures were not increased. Patients with craniopharyngioma also had excessive total mortality (SMR: 2.7, 95% CI: 2.0-3.8), and mortality due to circulatory (SMR: 2.3, 95% CI: 1.1-4.5) and respiratory (SMR: 6.0, 95% CI: 2.5-14.5) diseases. Female sex, childhood-onset craniopharyngioma, hydrocephalus and tumour recurrence were identified as risk factors for excess T2DM, cerebral infarction and total mortality.Patients with craniopharyngioma are at an increased risk for T2DM, cerebral infarction, total mortality and mortality due to circulatory and respiratory diseases. Female sex, childhood-onset craniopharyngioma, hydrocephalus and tumour recurrence are important risk factors. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
653 | a Adolescent | |
653 | a Adult | |
653 | a Age of Onset | |
653 | a Cerebral Infarction | |
653 | a complications | |
653 | a epidemiology | |
653 | a Child | |
653 | a Cohort Studies | |
653 | a Craniopharyngioma | |
653 | a epidemiology | |
653 | a mortality | |
653 | a Diabetes Mellitus | |
653 | a Type 2 | |
653 | a complications | |
653 | a epidemiology | |
653 | a Female | |
653 | a Hospital Mortality | |
653 | a Humans | |
653 | a Hydrocephalus | |
653 | a complications | |
653 | a epidemiology | |
653 | a mortality | |
653 | a Incidence | |
653 | a Male | |
653 | a Middle Aged | |
653 | a Morbidity | |
653 | a Netherlands | |
653 | a epidemiology | |
653 | a Pituitary Neoplasms | |
653 | a epidemiology | |
653 | a mortality | |
653 | a Retrospective Studies | |
653 | a Risk Factors | |
653 | a Sex Factors | |
653 | a Sweden | |
653 | a epidemiology | |
653 | a Young Adult | |
700 | 1 | a Olsson, Daniel S,d 1983u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xolssd |
700 | 1 | a van den Heuvel-Eibrink, Marry M4 aut |
700 | 1 | a Hammarstrand, Casper,d 1990u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xhammc |
700 | 1 | a Janssen, Joseph A M J L4 aut |
700 | 1 | a van der Lely, Aart J4 aut |
700 | 1 | a Johannsson, Gudmundur,d 1960u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xjgudn |
700 | 1 | a Neggers, Sebastian J C M M4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition4 org |
773 | 0 | t European journal of endocrinologyg 178:1, s. 95-104q 178:1<95-104x 1479-683X |
856 | 4 8 | u https://gup.ub.gu.se/publication/260615 |
856 | 4 8 | u https://doi.org/10.1530/EJE-17-0707 |
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